Md Mohaimenul Islam1,2,3, Tahmina Nasrin Poly1,2,3, Bruno Andreas Walther4, Hsuan Chia Yang1,2,3, Cheng-Wei Wang5, Wen-Shyang Hsieh6,7, Suleman Atique8, Hosna Salmani9, Belal Alsinglawi10, Ming Ching Lin1,11,12,13,14, Wen Shan Jian15, Yu-Chuan Jack Li1,2,3,16,17. 1. College of Medical Science and Technology, Graduate Institute of Biomedical Informatics, Taipei Medical University, Taipei, Taiwan. 2. International Center for Health Information Technology (ICHIT), Taipei Medical University, Taipei, Taiwan. 3. Research Center of Big Data and Meta-Analysis, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan. 4. Alfred-Wegener-Institut Helmholtz-Zentrum für Polar- und Meeresforschung, Bremerhaven, Germany. 5. Division of Reproduction Medicine, Department of Obstetrics and Gynecology, Taipei Medical University Hospital, Taipei, Taiwan. 6. Department of Medical Laboratory, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan. 7. Department of Medical Laboratory Science and Biotechnology, Fooyin University, Kaohsiung City, Taiwan. 8. College of Public Health and Health Informatics, University of Ha'il, Ha'il, Saudi Arabia. 9. School of Health Management and Information Sciences, Iran University of Medical Sciences, Tehran, Iran. 10. School of Computing, Engineering, and Mathematics, Western Sydney University, Penrith, NSW, Australia. 11. Department of Neurosurgery, Shuang Ho Hospital, Taipei Medical University, Taipei, Taiwan. 12. Professional Master Program in Artificial Intelligence in Medicine, Taipei Medical University, Taipei, Taiwan. 13. Research Center for Artificial Intelligence in Medicine, Taipei Medical University, Taipei, Taiwan. 14. Taipei Neuroscience Institute, Taipei Medical University, Taipei, Taiwan. 15. School of Health Care Administration, Taipei Medical University, Taipei, Taiwan. 16. Department of Dermatology, Wan Fang Hospital, Taipei, Taiwan. 17. Taipei Medical University Research Center of Cancer Translational Medicine, Taipei Medical University, Taipei, Taiwan.
Abstract
Background and Objective: Coronavirus disease 2019 (COVID-19) characterized by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has created serious concerns about its potential adverse effects. There are limited data on clinical, radiological, and neonatal outcomes of pregnant women with COVID-19 pneumonia. This study aimed to assess clinical manifestations and neonatal outcomes of pregnant women with COVID-19. Methods: We conducted a systematic article search of PubMed, EMBASE, Scopus, Google Scholar, and Web of Science for studies that discussed pregnant patients with confirmed COVID-19 between January 1, 2020, and April 20, 2020, with no restriction on language. Articles were independently evaluated by two expert authors. We included all retrospective studies that reported the clinical features and outcomes of pregnant patients with COVID-19. Results: Forty-seven articles were assessed for eligibility; 13 articles met the inclusion criteria for the systematic review. Data is reported for 235 pregnant women with COVID-19. The age range of patients was 25-40 years, and the gestational age ranged from 8 to 40 weeks plus 6 days. Clinical characteristics were fever [138/235 (58.72%)], cough [111/235 (47.23%)], and sore throat [21/235 (8.93%)]. One hundred fifty six out of 235 (66.38%) pregnant women had cesarean section, and 79 (33.62%) had a vaginal delivery. All the patients showed lung abnormalities in CT scan images, and none of the patients died. Neutrophil cell count, C-reactive protein (CRP) concentration, ALT, and AST were increased but lymphocyte count and albumin levels were decreased. Amniotic fluid, neonatal throat swab, and breastmilk samples were taken to test for SARS-CoV-2 but all found negativ results. Recent published evidence showed the possibility of vertical transmission up to 30%, and neonatal death up to 2.5%. Pre-eclampsia, fetal distress, PROM, pre-mature delivery were the major complications of pregnant women with COVID-19. Conclusions: Our study findings show that the clinical, laboratory and radiological characteristics of pregnant women with COVID-19 were similar to those of the general populations. The possibility of vertical transmission cannot be ignored but C-section should not be routinely recommended anymore according to latest evidences and, in any case, decisions should be taken after proper discussion with the family. Future studies are needed to confirm or refute these findings with a larger number of sample sizes and a long-term follow-up period.
Background and Objective: Coronavirus disease 2019 (COVID-19) characterized by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has created serious concerns about its potential adverse effects. There are limited data on clinical, radiological, and neonatal outcomes of pregnant women with COVID-19 pneumonia. This study aimed to assess clinical manifestations and neonatal outcomes of pregnant women with COVID-19. Methods: We conducted a systematic article search of PubMed, EMBASE, Scopus, Google Scholar, and Web of Science for studies that discussed pregnant patients with confirmed COVID-19 between January 1, 2020, and April 20, 2020, with no restriction on language. Articles were independently evaluated by two expert authors. We included all retrospective studies that reported the clinical features and outcomes of pregnant patients with COVID-19. Results: Forty-seven articles were assessed for eligibility; 13 articles met the inclusion criteria for the systematic review. Data is reported for 235 pregnant women with COVID-19. The age range of patients was 25-40 years, and the gestational age ranged from 8 to 40 weeks plus 6 days. Clinical characteristics were fever [138/235 (58.72%)], cough [111/235 (47.23%)], and sore throat [21/235 (8.93%)]. One hundred fifty six out of 235 (66.38%) pregnant women had cesarean section, and 79 (33.62%) had a vaginal delivery. All the patients showed lung abnormalities in CT scan images, and none of the patientsdied. Neutrophil cell count, C-reactive protein (CRP) concentration, ALT, and AST were increased but lymphocyte count and albumin levels were decreased. Amniotic fluid, neonatal throat swab, and breastmilk samples were taken to test for SARS-CoV-2 but all found negativ results. Recent published evidence showed the possibility of vertical transmission up to 30%, and neonatal death up to 2.5%. Pre-eclampsia, fetal distress, PROM, pre-mature delivery were the major complications of pregnant women with COVID-19. Conclusions: Our study findings show that the clinical, laboratory and radiological characteristics of pregnant women with COVID-19 were similar to those of the general populations. The possibility of vertical transmission cannot be ignored but C-section should not be routinely recommended anymore according to latest evidences and, in any case, decisions should be taken after proper discussion with the family. Future studies are needed to confirm or refute these findings with a larger number of sample sizes and a long-term follow-up period.
Authors: Greg Marchand; Avinash S Patil; Ahmed T Masoud; Kelly Ware; Alexa King; Stacy Ruther; Giovanna Brazil; Nicolas Calteux; Hollie Ulibarri; Julia Parise; Amanda Arroyo; Catherine Coriell; Chelsea Cook; Alexandra Ruuska; Anas Zakarya Nourelden; Katelyn Sainz Journal: AJOG Glob Rep Date: 2022-01-03
Authors: Habib Sadeghi Rad; Joan Röhl; Nataly Stylianou; Mark C Allenby; Sajad Razavi Bazaz; Majid E Warkiani; Fernando S F Guimaraes; Vicki L Clifton; Arutha Kulasinghe Journal: Front Immunol Date: 2021-09-15 Impact factor: 8.786
Authors: Anne C Verheijen; Eva E R Janssen; Mayke E van der Putten; Marieke W P van Horck; Gijs T J van Well; Inge H M Van Loo; Matthias C Hütten; Karen Van Mechelen Journal: J Med Case Rep Date: 2022-03-28