Literature DB >> 33391882

Dnajb8, a target gene of SOX30, is dispensable for male fertility in mice.

Fengsong Wang1, Shuai Kong1, Xuechun Hu2, Xin Li3, Bo Xu4, Qiuling Yue5, Kaiqiang Fu6, Lan Ye3, Shun Bai4.   

Abstract

BACKGROUND: The DNAJ family of molecular chaperones maintains protein homeostasis in mitotic and postmeiotic cells, especially germ cells. Recently, we found that the transcription factor SOX30 initiates transcription of Dnajb8 during late meiosis and spermiogenesis in mouse testes.
METHODS: We used the CRISPR/Cas9 system to generate Dnajb8 mutant mice and analyze the phenotype of the Dnajb8 mutants.
RESULTS: Although Dnajb8 is an evolutionarily conserved gene, it is not essential for spermatogenesis and male fertility. We provide this phenotypic information, which could prevent duplicative work by other groups. ©2020 Wang et al.

Entities:  

Keywords:  Dnajb8; Male fertility; Spermatogenesis

Year:  2020        PMID： 33391882      PMCID： PMC7759119          DOI： 10.7717/peerj.10582

Source DB:  PubMed          Journal:  PeerJ        ISSN： 2167-8359            Impact factor:   2.984


  20 in total

1.  Cellular source and mechanisms of high transcriptome complexity in the mammalian testis.

Authors:  Magali Soumillon; Anamaria Necsulea; Manuela Weier; David Brawand; Xiaolan Zhang; Hongcang Gu; Pauline Barthès; Maria Kokkinaki; Serge Nef; Andreas Gnirke; Martin Dym; Bernard de Massy; Tarjei S Mikkelsen; Henrik Kaessmann
Journal:  Cell Rep       Date:  2013-06-20       Impact factor: 9.423

Review 2.  Structure, function and evolution of DnaJ: conservation and adaptation of chaperone function.

Authors:  M E Cheetham; A J Caplan
Journal:  Cell Stress Chaperones       Date:  1998-03       Impact factor: 3.667

3.  Sox30 initiates transcription of haploid genes during late meiosis and spermiogenesis in mouse testes.

Authors:  Shun Bai; Kaiqiang Fu; Huiqi Yin; Yiqiang Cui; Qiuling Yue; Wenbo Li; Le Cheng; Huanhuan Tan; Xiaofei Liu; Yueshuai Guo; Yingwen Zhang; Jie Xie; Wenxiu He; Yuanyuan Wang; Hua Feng; Changpeng Xin; Jinwen Zhang; Mingyan Lin; Bin Shen; Zheng Sun; Xuejiang Guo; Ke Zheng; Lan Ye
Journal:  Development       Date:  2018-07-04       Impact factor: 6.868

4.  Mutations in DNAJB13, Encoding an HSP40 Family Member, Cause Primary Ciliary Dyskinesia and Male Infertility.

Authors:  Elma El Khouri; Lucie Thomas; Ludovic Jeanson; Emilie Bequignon; Benoit Vallette; Philippe Duquesnoy; Guy Montantin; Bruno Copin; Florence Dastot-Le Moal; Sylvain Blanchon; Jean François Papon; Patrick Lorès; Li Yuan; Nathalie Collot; Sylvie Tissier; Catherine Faucon; Gérard Gacon; Catherine Patrat; Jean Philippe Wolf; Emmanuel Dulioust; Bruno Crestani; Estelle Escudier; André Coste; Marie Legendre; Aminata Touré; Serge Amselem
Journal:  Am J Hum Genet       Date:  2016-08-04       Impact factor: 11.025

5.  Spermatogenesis.

Authors:  Hitoshi Nishimura; Steven W L'Hernault
Journal:  Curr Biol       Date:  2017-09-25       Impact factor: 10.834

6.  Mechanistic insights into acephalic spermatozoa syndrome-associated mutations in the human SUN5 gene.

Authors:  Yongliang Shang; Jie Yan; Wenhao Tang; Chao Liu; Sai Xiao; Yueshuai Guo; Li Yuan; Liang Chen; Hui Jiang; Xuejiang Guo; Jie Qiao; Wei Li
Journal:  J Biol Chem       Date:  2018-01-03       Impact factor: 5.157

7.  MSJ-1, a mouse testis-specific DnaJ protein, is highly expressed in haploid male germ cells and interacts with the testis-specific heat shock protein Hsp70-2.

Authors:  G Berruti; E Martegani
Journal:  Biol Reprod       Date:  2001-08       Impact factor: 4.285

8.  HSP DNAJB8 controls tumor-initiating ability in renal cancer stem-like cells.

Authors:  Satoshi Nishizawa; Yoshihiko Hirohashi; Toshihiko Torigoe; Akari Takahashi; Yasuaki Tamura; Takashi Mori; Takayuki Kanaseki; Kenjiro Kamiguchi; Hiroko Asanuma; Rena Morita; Alice Sokolovskaya; Junichi Matsuzaki; Ren Yamada; Reona Fujii; Harm H Kampinga; Toru Kondo; Tadashi Hasegawa; Isao Hara; Noriyuki Sato
Journal:  Cancer Res       Date:  2012-05-02       Impact factor: 12.701

9.  Identification of a heat-shock protein Hsp40, DjB1, as an acrosome- and a tail-associated component in rodent spermatozoa.

Authors:  Masamichi Doiguchi; Takane Kaneko; Aiko Urasoko; Hideo Nishitani; Hiroshi Iida
Journal:  Mol Reprod Dev       Date:  2007-02       Impact factor: 2.609

10.  Cellular stress induces cancer stem-like cells through expression of DNAJB8 by activation of heat shock factor 1.

Authors:  Hiroki Kusumoto; Yoshihiko Hirohashi; Satoshi Nishizawa; Masamichi Yamashita; Kazuyo Yasuda; Aiko Murai; Akari Takaya; Takashi Mori; Terufumi Kubo; Munehide Nakatsugawa; Takayuki Kanaseki; Tomohide Tsukahara; Toru Kondo; Noriyuki Sato; Isao Hara; Toshihiko Torigoe
Journal:  Cancer Sci       Date:  2018-02-20       Impact factor: 6.716
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  2 in total

1.  G3BP2, a stress granule assembly factor, is dispensable for spermatogenesis in mice.

Authors:  Damin Yun; Liwei Zhou; Jie Shi; Xinyao Li; Xiaolong Wu; Fei Sun
Journal:  PeerJ       Date:  2022-06-28       Impact factor: 3.061

2.  Structural and Functional Characterization of a Testicular Long Non-coding RNA (4930463O16Rik) Identified in the Meiotic Arrest of the Mouse Topaz1 -/- Testes.

Authors:  Manon Chadourne; Elodie Poumerol; Luc Jouneau; Bruno Passet; Johan Castille; Eli Sellem; Eric Pailhoux; Béatrice Mandon-Pépin
Journal:  Front Cell Dev Biol       Date:  2021-07-01
  2 in total

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