Literature DB >> 33391636

Extracellular vesicles containing ACE2 efficiently prevent infection by SARS-CoV-2 Spike protein-containing virus.

Federico Cocozza1,2, Nathalie Névo1, Ester Piovesana1,2, Xavier Lahaye1, Julian Buchrieser3, Olivier Schwartz3, Nicolas Manel1, Mercedes Tkach1, Clotilde Théry1, Lorena Martin-Jaular1.   

Abstract

SARS-CoV-2 entry is mediated by binding of the spike protein (S) to the surface receptor ACE2 and subsequent priming by host TMPRSS2 allowing membrane fusion. Here, we produced extracellular vesicles (EVs) exposing ACE2 and demonstrate that ACE2-EVs are efficient decoys for SARS-CoV-2 S protein-containing lentivirus. Reduction of infectivity positively correlates with the level of ACE2, is much more efficient than with soluble ACE2 and further enhanced by the inclusion of TMPRSS2.
© 2020 The Authors. Journal of Extracellular Vesicles published by Wiley Periodicals, LLC on behalf of the International Society for Extracellular Vesicles.

Entities:  

Keywords:  ACE2; EV therapy; SARS‐CoV‐2; TMPRSS2

Year:  2020        PMID： 33391636      PMCID： PMC7769856          DOI： 10.1002/jev2.12050

Source DB:  PubMed          Journal:  J Extracell Vesicles        ISSN： 2001-3078


  23 in total

1.  EV-TRACK: transparent reporting and centralizing knowledge in extracellular vesicle research.

Authors:  Jan Van Deun; Pieter Mestdagh; Patrizia Agostinis; Özden Akay; Sushma Anand; Jasper Anckaert; Zoraida Andreu Martinez; Tine Baetens; Els Beghein; Laurence Bertier; Geert Berx; Janneke Boere; Stephanie Boukouris; Michel Bremer; Dominik Buschmann; James B Byrd; Clara Casert; Lesley Cheng; Anna Cmoch; Delphine Daveloose; Eva De Smedt; Seyma Demirsoy; Victoria Depoorter; Bert Dhondt; Tom A P Driedonks; Aleksandra Dudek; Abdou Elsharawy; Ilaria Floris; Andrew D Foers; Kathrin Gärtner; Abhishek D Garg; Edward Geeurickx; Jan Gettemans; Farzaneh Ghazavi; Bernd Giebel; Tom Groot Kormelink; Grace Hancock; Hetty Helsmoortel; Andrew F Hill; Vincent Hyenne; Hina Kalra; David Kim; Joanna Kowal; Sandra Kraemer; Petra Leidinger; Carina Leonelli; Yaxuan Liang; Lien Lippens; Shu Liu; Alessandra Lo Cicero; Shaun Martin; Suresh Mathivanan; Prabhu Mathiyalagan; Támas Matusek; Gloria Milani; Marta Monguió-Tortajada; Liselot M Mus; Dillon C Muth; Andrea Németh; Esther N M Nolte-'t Hoen; Lorraine O'Driscoll; Roberta Palmulli; Michael W Pfaffl; Bjarke Primdal-Bengtson; Erminia Romano; Quentin Rousseau; Susmita Sahoo; Natalia Sampaio; Monisha Samuel; Benjamin Scicluna; Bieke Soen; Anneleen Steels; Johannes V Swinnen; Maarit Takatalo; Safia Thaminy; Clotilde Théry; Joeri Tulkens; Isabel Van Audenhove; Susanne van der Grein; Alan Van Goethem; Martijn J van Herwijnen; Guillaume Van Niel; Nadine Van Roy; Alexander R Van Vliet; Niels Vandamme; Suzanne Vanhauwaert; Glenn Vergauwen; Frederik Verweij; Annelynn Wallaert; Marca Wauben; Kenneth W Witwer; Marijke I Zonneveld; Olivier De Wever; Jo Vandesompele; An Hendrix
Journal:  Nat Methods       Date:  2017-02-28       Impact factor: 28.547

2.  Catalytic cleavage of the androgen-regulated TMPRSS2 protease results in its secretion by prostate and prostate cancer epithelia.

Authors:  D E Afar; I Vivanco; R S Hubert; J Kuo; E Chen; D C Saffran; A B Raitano; A Jakobovits
Journal:  Cancer Res       Date:  2001-02-15       Impact factor: 12.701

3.  ESCRT III repairs nuclear envelope ruptures during cell migration to limit DNA damage and cell death.

Authors:  M Raab; M Gentili; H de Belly; H R Thiam; P Vargas; A J Jimenez; F Lautenschlaeger; Raphaël Voituriez; A M Lennon-Duménil; N Manel; M Piel
Journal:  Science       Date:  2016-03-24       Impact factor: 47.728

4.  Retroviruses pseudotyped with the severe acute respiratory syndrome coronavirus spike protein efficiently infect cells expressing angiotensin-converting enzyme 2.

Authors:  Michael J Moore; Tatyana Dorfman; Wenhui Li; Swee Kee Wong; Yanhan Li; Jens H Kuhn; James Coderre; Natalya Vasilieva; Zhongchao Han; Thomas C Greenough; Michael Farzan; Hyeryun Choe
Journal:  J Virol       Date:  2004-10       Impact factor: 5.103

5.  Rescue of human immunodeficiency virus type 1 matrix protein mutants by envelope glycoproteins with short cytoplasmic domains.

Authors:  F Mammano; E Kondo; J Sodroski; A Bukovsky; H G Göttlinger
Journal:  J Virol       Date:  1995-06       Impact factor: 5.103

6.  TMPRSS2 Isoform 1 Activates Respiratory Viruses and Is Expressed in Viral Target Cells.

Authors:  Pawel Zmora; Anna-Sophie Moldenhauer; Heike Hofmann-Winkler; Stefan Pöhlmann
Journal:  PLoS One       Date:  2015-09-17       Impact factor: 3.240

7.  Intrinsic antiproliferative activity of the innate sensor STING in T lymphocytes.

Authors:  Silvia Cerboni; Nadia Jeremiah; Matteo Gentili; Ulf Gehrmann; Cécile Conrad; Marie-Claude Stolzenberg; Capucine Picard; Bénédicte Neven; Alain Fischer; Sébastian Amigorena; Frédéric Rieux-Laucat; Nicolas Manel
Journal:  J Exp Med       Date:  2017-05-08       Impact factor: 14.307

8.  International Society for Extracellular Vesicles and International Society for Cell and Gene Therapy statement on extracellular vesicles from mesenchymal stromal cells and other cells: considerations for potential therapeutic agents to suppress coronavirus disease-19.

Authors:  Verena Börger; Daniel J Weiss; Johnathon D Anderson; Francesc E Borràs; Benedetta Bussolati; David R F Carter; Massimo Dominici; Juan M Falcón-Pérez; Mario Gimona; Andrew F Hill; Andrew M Hoffman; Dominique de Kleijn; Bruce L Levine; Rebecca Lim; Jan Lötvall; S Alex Mitsialis; Marta Monguió-Tortajada; Maurizio Muraca; Rienk Nieuwland; Anna Nowocin; Lorraine O'Driscoll; Luis A Ortiz; Donald G Phinney; Ilona Reischl; Eva Rohde; Ralf Sanzenbacher; Clotilde Théry; Wei Seong Toh; Kenneth W Witwer; Sai Kiang Lim; Bernd Giebel
Journal:  Cytotherapy       Date:  2020-05-16       Impact factor: 5.414

9.  A pneumonia outbreak associated with a new coronavirus of probable bat origin.

Authors:  Peng Zhou; Xing-Lou Yang; Xian-Guang Wang; Ben Hu; Lei Zhang; Wei Zhang; Hao-Rui Si; Yan Zhu; Bei Li; Chao-Lin Huang; Hui-Dong Chen; Jing Chen; Yun Luo; Hua Guo; Ren-Di Jiang; Mei-Qin Liu; Ying Chen; Xu-Rui Shen; Xi Wang; Xiao-Shuang Zheng; Kai Zhao; Quan-Jiao Chen; Fei Deng; Lin-Lin Liu; Bing Yan; Fa-Xian Zhan; Yan-Yi Wang; Geng-Fu Xiao; Zheng-Li Shi
Journal:  Nature       Date:  2020-02-03       Impact factor: 69.504

10.  Decoy ACE2-expressing extracellular vesicles that competitively bind SARS-CoV-2 as a possible COVID-19 therapy.

Authors:  Jameel M Inal
Journal:  Clin Sci (Lond)       Date:  2020-06-26       Impact factor: 6.124
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  40 in total

Review 1.  A systemic review on liquid crystals, nanoformulations and its application for detection and treatment of SARS - CoV- 2 (COVID - 19).

Authors:  Ayushi Rastogi; Abhilasha Singh; Kaustubh Naik; Archana Mishra; Shilpi Chaudhary; Rajiv Manohar; Avanish Singh Parmar
Journal:  J Mol Liq       Date:  2022-07-08       Impact factor: 6.633

2.  Serum extracellular vesicles profiling is associated with COVID-19 progression and immune responses.

Authors:  Kevin Ho Wai Yim; Simone Borgoni; Richard Chahwan
Journal:  J Extracell Biol       Date:  2022-04-20

Review 3.  Extracellular Vesicles as Promising Carriers in Drug Delivery: Considerations from a Cell Biologist's Perspective.

Authors:  Giona Pedrioli; Ester Piovesana; Elena Vacchi; Carolina Balbi
Journal:  Biology (Basel)       Date:  2021-04-27

Review 4.  ACE2-based decoy receptors for SARS coronavirus 2.

Authors:  Wenyang Jing; Erik Procko
Journal:  Proteins       Date:  2021-05-18

5.  Elucidating Design Principles for Engineering Cell-Derived Vesicles to Inhibit SARS-CoV-2 Infection.

Authors:  Taylor F Gunnels; Devin M Stranford; Roxana E Mitrut; Neha P Kamat; Joshua N Leonard
Journal:  Small       Date:  2022-04-07       Impact factor: 15.153

6.  Soluble ACE2-mediated cell entry of SARS-CoV-2 via interaction with proteins related to the renin-angiotensin system.

Authors:  Man Lung Yeung; Jade Lee Lee Teng; Lilong Jia; Chaoyu Zhang; Chengxi Huang; Jian-Piao Cai; Runhong Zhou; Kwok-Hung Chan; Hanjun Zhao; Lin Zhu; Kam-Leung Siu; Sin-Yee Fung; Susan Yung; Tak Mao Chan; Kelvin Kai-Wang To; Jasper Fuk-Woo Chan; Zongwei Cai; Susanna Kar Pui Lau; Zhiwei Chen; Dong-Yan Jin; Patrick Chiu Yat Woo; Kwok-Yung Yuen
Journal:  Cell       Date:  2021-03-02       Impact factor: 41.582

Review 7.  Bio-inspired nanomaterials as novel options for the treatment of cardiovascular disease.

Authors:  Rajendran Jc Bose; Khan Ha; Jason R McCarthy
Journal:  Drug Discov Today       Date:  2021-02-06       Impact factor: 7.851

Review 8.  Viral Bad News Sent by EVAIL.

Authors:  Matthias Clauss; Sarvesh Chelvanambi; Christine Cook; Rabab ElMergawy; Navneet Dhillon
Journal:  Viruses       Date:  2021-06-18       Impact factor: 5.048

9.  Extracellular vesicle-mediated endothelial apoptosis and EV-associated proteins correlate with COVID-19 disease severity.

Authors:  Balaji Krishnamachary; Christine Cook; Ashok Kumar; Leslie Spikes; Prabhakar Chalise; Navneet K Dhillon
Journal:  J Extracell Vesicles       Date:  2021-07-03

10.  Extracellular vesicles carry SARS-CoV-2 spike protein and serve as decoys for neutralizing antibodies.

Authors:  Zach Troyer; Najwa Alhusaini; Caroline O Tabler; Thomas Sweet; Karina Inacio Ladislau de Carvalho; Daniela M Schlatzer; Lenore Carias; Christopher L King; Kenneth Matreyek; John C Tilton
Journal:  J Extracell Vesicles       Date:  2021-06-18
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