Yiming Zhao1, Weiwei Liang1, Feng Cai2, Qun Wu2, Yongjian Wang1. 1. Department of Endocrinology and Metabolism, The Second Affiliated Hospital Zhejiang University School of Medicine, Hangzhou, China. 2. Department of Neurosurgery, The Second Affiliated Hospital Zhejiang University School of Medicine, Hangzhou, China.
Abstract
Background: Cushing's disease is associated with an increased risk of pulmonary fungal infection, which could be a relative contraindication for pituitary adenoma excision surgery. Case: We report a case of a patient with Cushing's disease and pulmonary Cryptococcus neoformans. A 48-year-old woman was admitted to our hospital because of moon face and edema. Laboratory and radiological findings suggested a diagnosis of Cushing's disease and pulmonary cryptococcus infection. Fluconazole 400 mg per day was administered intravenously and continued orally for 3 months. Both cryptococcus infection and hypercortisolism relieved and transsphenoidal resection was performed. Conclusion: Cushing's disease can be effectively treated with fluconazole to normalize cortisol concentration prior to pituitary surgery. Fluconazole is an alternative treatment especially in Cushing's disease patients with cryptococcal pneumonia.
Background: Cushing's disease is associated with an increased risk of pulmonary fungal infection, which could be a relative contraindication for pituitary adenoma excision surgery. Case: We report a case of a patient with Cushing's disease and pulmonary Cryptococcus neoformans. A 48-year-old woman was admitted to our hospital because of moon face and edema. Laboratory and radiological findings suggested a diagnosis of Cushing's disease and pulmonary cryptococcus infection. Fluconazole 400 mg per day was administered intravenously and continued orally for 3 months. Both cryptococcus infection and hypercortisolism relieved and transsphenoidal resection was performed. Conclusion:Cushing's disease can be effectively treated with fluconazole to normalize cortisol concentration prior to pituitary surgery. Fluconazole is an alternative treatment especially in Cushing's diseasepatients with cryptococcal pneumonia.
Authors: S Shibata; M Kami; Y Kanda; U Machida; H Iwata; Y Kishi; A Takeshita; S Miyakoshi; J Ueyama; S Morinaga; Y Mutou Journal: Am J Hematol Date: 2001-04 Impact factor: 10.047
Authors: Richard A Feelders; John Newell-Price; Rosario Pivonello; Lynnette K Nieman; Leo J Hofland; Andre Lacroix Journal: Lancet Diabetes Endocrinol Date: 2018-07-20 Impact factor: 32.069
Authors: R van der Pas; L J Hofland; J Hofland; A E Taylor; W Arlt; J Steenbergen; P M van Koetsveld; W W de Herder; F H de Jong; R A Feelders Journal: J Endocrinol Date: 2012-10-04 Impact factor: 4.286
Authors: Maria Fleseriu; Rosario Pivonello; Atanaska Elenkova; Roberto Salvatori; Richard J Auchus; Richard A Feelders; Eliza B Geer; Yona Greenman; Przemyslaw Witek; Fredric Cohen; Beverly M K Biller Journal: Lancet Diabetes Endocrinol Date: 2019-09-18 Impact factor: 32.069
Authors: D Dworakowska; E Wlodek; C A Leontiou; S Igreja; M Cakir; M Teng; N Prodromou; M I Góth; S Grozinsky-Glasberg; M Gueorguiev; B Kola; M Korbonits; A B Grossman Journal: Endocr Relat Cancer Date: 2009-07-20 Impact factor: 5.678
Authors: Verena Schwetz; Felix Aberer; Claudia Stiegler; Thomas R Pieber; Barbara Obermayer-Pietsch; Stefan Pilz Journal: Endocrinol Diabetes Metab Case Rep Date: 2015-05-21
Authors: Damian Szklarczyk; Alberto Santos; Christian von Mering; Lars Juhl Jensen; Peer Bork; Michael Kuhn Journal: Nucleic Acids Res Date: 2015-11-20 Impact factor: 16.971