Literature DB >> 33390844

Biological characteristics of IL-6 and related intestinal diseases.

Yuexin Guo1, Boya Wang2, Tiantian Wang3, Lei Gao4, Ze-Jun Yang5, Fei-Fei Wang5, Hong-Wei Shang6, Rongxuan Hua5, Jing-Dong Xu3.   

Abstract

The intestine serves as an important digestive and the largest immune organ in the body. Interleukin-6(IL-6), an important mediator of various pathways, participates in the interactions between different kinds of cells and closely correlates with intestinal physiological and pathological condition. In this review we summarize the signaling pathways of IL-6 and its functions in maintaining intestinal homeostasis. We also explored its relation with nervous system and highlight its potential role in Parkinson's disease. Based on its specialty of the double-side influences on intestinal tumors and inflammation, we summarize how they are done through distinctive process. © The author(s).

Entities:  

Keywords:  Inflammation; Interleukin-6(IL-6); Intestinal diseases; Nerve Immune barrier; Tumor

Mesh：

Substances：

Year:  2021        PMID： 33390844      PMCID： PMC7757046          DOI： 10.7150/ijbs.51362

Source DB:  PubMed          Journal:  Int J Biol Sci        ISSN： 1449-2288            Impact factor:   6.580


  148 in total

1.  Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells.

Authors:  Estelle Bettelli; Yijun Carrier; Wenda Gao; Thomas Korn; Terry B Strom; Mohamed Oukka; Howard L Weiner; Vijay K Kuchroo
Journal:  Nature       Date:  2006-04-30       Impact factor: 49.962

2.  IL-6 trans-signaling licenses mouse and human tumor microvascular gateways for trafficking of cytotoxic T cells.

Authors:  Daniel T Fisher; Qing Chen; Joseph J Skitzki; Jason B Muhitch; Lei Zhou; Michelle M Appenheimer; Trupti D Vardam; Emily L Weis; Jessica Passanese; Wan-Chao Wang; Sandra O Gollnick; Mark W Dewhirst; Stefan Rose-John; Elizabeth A Repasky; Heinz Baumann; Sharon S Evans
Journal:  J Clin Invest       Date:  2011-09-19       Impact factor: 14.808

3.  A gp130-Src-YAP module links inflammation to epithelial regeneration.

Authors:  Koji Taniguchi; Li-Wha Wu; Sergei I Grivennikov; Petrus R de Jong; Ian Lian; Fa-Xing Yu; Kepeng Wang; Samuel B Ho; Brigid S Boland; John T Chang; William J Sandborn; Gary Hardiman; Eyal Raz; Yoshihiko Maehara; Akihiko Yoshimura; Jessica Zucman-Rossi; Kun-Liang Guan; Michael Karin
Journal:  Nature       Date:  2015-02-25       Impact factor: 49.962

4.  Mechanisms involved in down-regulation of intestinal IgA in rats by high cocoa intake.

Authors:  Teresa Pérez-Berezo; Angels Franch; Cristina Castellote; Margarida Castell; Francisco J Pérez-Cano
Journal:  J Nutr Biochem       Date:  2011-08-12       Impact factor: 6.048

5.  Rapamycin suppresses TLR4-triggered IL-6 and PGE(2) production of colon cancer cells by inhibiting TLR4 expression and NF-kappaB activation.

Authors:  Qiaoling Sun; Qiuyang Liu; Yuanyuan Zheng; Xuetao Cao
Journal:  Mol Immunol       Date:  2008-03-17       Impact factor: 4.407

6.  Modulation of VIPergic phenotype of enteric neurons by colonic biopsy supernatants from patients with inflammatory bowel diseases: Involvement of IL-6 in Crohn's disease.

Authors:  F Soufflet; M Biraud; M Rolli-Derkinderen; B Lardeux; C Trang; E Coron; S Bruley des Varannes; A Bourreille; M Neunlist
Journal:  Neurogastroenterol Motil       Date:  2017-08-31       Impact factor: 3.598

7.  Abnormal Paneth cell granule dissolution and compromised resistance to bacterial colonization in the intestine of CF mice.

Authors:  Lane L Clarke; Lara R Gawenis; Emily M Bradford; Louise M Judd; Kathryn T Boyle; Janet E Simpson; Gary E Shull; Hiroki Tanabe; Andre J Ouellette; Craig L Franklin; Nancy M Walker
Journal:  Am J Physiol Gastrointest Liver Physiol       Date:  2004-01-08       Impact factor: 4.052

8.  Epithelial: lamina propria lymphocyte interactions promote epithelial cell differentiation.

Authors:  Stephanie Dahan; Giulia Roda; David Pinn; Franziska Roth-Walter; Okebugwu Kamalu; Andrea P Martin; Lloyd Mayer
Journal:  Gastroenterology       Date:  2007-10-17       Impact factor: 22.682

Review 9.  ADAM17 Activity and IL-6 Trans-Signaling in Inflammation and Cancer.

Authors:  Neele Schumacher; Stefan Rose-John
Journal:  Cancers (Basel)       Date:  2019-11-05       Impact factor: 6.639

10.  Activated intestinal macrophages in patients with cirrhosis release NO and IL-6 that may disrupt intestinal barrier function.

Authors:  Elizabeth C Goode; Richard C Warburton; William T H Gelson; Alastair J M Watson
Journal:  Gastroenterology       Date:  2013-12       Impact factor: 22.682
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  4 in total

Review 1.  Contribution of Epithelial and Gut Microbiome Inflammatory Biomarkers to the Improvement of Colorectal Cancer Patients' Stratification.

Authors:  Elena Ionica; Gisela Gaina; Mihaela Tica; Mariana-Carmen Chifiriuc; Gratiela Gradisteanu-Pircalabioru
Journal:  Front Oncol       Date:  2022-02-07       Impact factor: 6.244

2.  PI3K Signaling in Dendritic Cells Aggravates DSS-Induced Colitis.

Authors:  Mario Kuttke; Dominika Hromadová; Ceren Yildirim; Julia S Brunner; Andrea Vogel; Hannah Paar; Sophie Peters; Maria Weber; Melanie Hofmann; Martina Kerndl; Markus Kieler; Hannes Datler; Laszlo Musiejovsky; Manuel Salzmann; Michaela Lang; Klara Soukup; Angela Halfmann; Omar Sharif; Gernot Schabbauer
Journal:  Front Immunol       Date:  2022-04-19       Impact factor: 8.786

3.  Butyrate Glycerides Protect against Intestinal Inflammation and Barrier Dysfunction in Mice.

Authors:  Haidong Wang; Haohan Chen; Yueying Lin; Geng Wang; Yanqiu Luo; Xinyu Li; Minqi Wang; Mingyan Huai; Lily Li; Adriana Barri
Journal:  Nutrients       Date:  2022-09-26       Impact factor: 6.706

4.  RNA-seq and In Vitro Experiments Reveal the Protective Effect of Curcumin against 5-Fluorouracil-Induced Intestinal Mucositis via IL-6/STAT3 Signaling Pathway.

Authors:  Xuan-Ying Wang; Bo Zhang; Yi Lu; Lu Xu; Yi-Jie Wang; Bi-Yu Cai; Qing-Hua Yao
Journal:  J Immunol Res       Date:  2021-07-21       Impact factor: 4.818
  4 in total

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