Recent developments on solid-state fermentation for production of microbial secondary metabolites: Challenges and solutions.

Microbial secondary metabolites (SMs) are the intermediate or the product of metabolism produced during fermentation process. SMs are produced during stationary phase and play a major role in competition, antagonism and self defence mechanisms. These metabolites finds application in the pharmaceuticals, food, cosmetics etc. These are produced besides primary key metabolites (e.g., amino acids, lipids, carbohydrates etc.). Growth condition in solid-state fermentation (SSF) resembles microorganism's own native environment allowing the microorganisms to adapt best. Recent developments in bioprocessing has identified specific SSF practices that have a significant impact on SMs production. The practice of SSF, representing new opportunities to design better bioprocessing with potential genetic development goals for expanding the list of exciting SMs. Current updates cover advanced techniques on SSF to improve microbial SMs production and their ease of operation and cost-effective production strategies. Various factors affecting the SSF have been discussed with respect to sustainable development of novel SSF strategies for SMs production.