An Insight Into Mitochondrial Dysfunction and its Implications in Neuro-logical Diseases.

In the last few years, a massive increase in the research has been observed that focusses on investigating the role of mitochondria in pathogenesis of several neurodegenerative disorders. Mitochondria are vital cell organelles having im-portant roles in different cellular processes including energy production, calcium signaling, ROS generation, apoptosis, etc. Therefore, healthy mitochondria are necessary for cell survival and functioning. It would seem feasible that mitochondrial dysfunction will have implications in various pathological conditions. A large body of evidence indicates the role of mito-chondrion as a potential key player in the loss or dysfunction of neurons in various neurodegenerative disorders. In this review, we provide an insight into the mitochondrial dysfunction and its involvement in the pathology of several neurolog-ical diseases such as Alzheimer's disease, Parkinson's disease, Amyotrophic Lateral Sclerosis, Hypoxic-Ischemic Brain Injury and many more. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.