Aung Zaw Zaw Phyo1, Joanne Ryan1,2, David A Gonzalez-Chica3,4, Robyn L Woods1, Christopher M Reid1,5, Mark R Nelson1,6, Anne M Murray7,8, Danijela Gasevic1,9, Nigel P Stocks3, Rosanne Freak-Poli10,11. 1. Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, 553 St Kilda Road, Melbourne, VIC, 3004, Australia. 2. PSNREC, Univ Montpellier, INSERM, 34000, Montpellier, France. 3. Discipline of General Practice, Adelaide Medical School, The University of Adelaide, Adelaide, SA, 5005, Australia. 4. Adelaide Rural Clinical School, The University of Adelaide, Adelaide, SA, 5005, Australia. 5. School of Public Health, Curtin University, Perth, WA, 6102, Australia. 6. Menzies Institute for Medical Research, University of Tasmania, Hobart, TAS, 7000, Australia. 7. Berman Center for Outcomes and Clinical Research, Hennepin HealthCare Research Institute, Hennepin HealthCare, Minneapolis, MN, 55415, USA. 8. Division of Geriatrics, Department of Medicine, Hennepin HealthCare and University of Minnesota, Minneapolis, MN, 55415, USA. 9. Usher Institute, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, UK. 10. Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, 553 St Kilda Road, Melbourne, VIC, 3004, Australia. Rosanne.Freak-Poli@monash.edu. 11. Department of Epidemiology, Erasmus Medical Centre, 3015 GD, Rotterdam, The Netherlands. Rosanne.Freak-Poli@monash.edu.
Abstract
PURPOSE: Previous research has demonstrated that lower health-related quality of life (HRQoL) is associated with higher morbidity and mortality, especially in-patient groups. The association of HRQoL with all-cause mortality in community samples requires further investigation. This study aimed to examine whether HRQoL predicts all-cause mortality in older healthy community-dwelling people from Australia and the United States (U.S.) enrolled in the Aspirin in Reducing Events in the Elderly (ASPREE) trial. We also explored whether this association varies by gender or country. METHOD: A prospective cohort of 19,106 individuals aged 65-98 years, who were without a dementia diagnosis or a known major life-limiting disease, and completed the 12-item short-form-HRQoL at recruitment (2010-2014). They were followed until June 2017. Cox proportional-hazard models were used to determine the association between the physical (PCS) and mental component scores (MCS) of HRQoL and all-cause mortality, adjusting for sociodemographic factors, health-related behaviours and clinical measures. Hazards ratios were estimated for every 10-unit increase in PCS or MCS. RESULTS: There were 1052 deaths over a median 4.7-years (interquartile range 3.6-5.7) of follow-up, with 11.9 events per 1000 person-years. Higher PCS was associated with lower all-cause mortality (HR 0.83, 95% CI 0.77, 0.89) in the entire sample, while higher MCS was associated with lower mortality among U.S. participants only (HR 0.78, 95% CI 0.63, 0.95). Gender differences in the association of either PCS or MCS with mortality were not observed. CONCLUSION: Our large study provides evidence that HRQoL is inversely associated with all-cause mortality among initially healthy older people.
PURPOSE: Previous research has demonstrated that lower health-related quality of life (HRQoL) is associated with higher morbidity and mortality, especially in-patient groups. The association of HRQoL with all-cause mortality in community samples requires further investigation. This study aimed to examine whether HRQoL predicts all-cause mortality in older healthy community-dwelling people from Australia and the United States (U.S.) enrolled in the Aspirin in Reducing Events in the Elderly (ASPREE) trial. We also explored whether this association varies by gender or country. METHOD: A prospective cohort of 19,106 individuals aged 65-98 years, who were without a dementia diagnosis or a known major life-limiting disease, and completed the 12-item short-form-HRQoL at recruitment (2010-2014). They were followed until June 2017. Cox proportional-hazard models were used to determine the association between the physical (PCS) and mental component scores (MCS) of HRQoL and all-cause mortality, adjusting for sociodemographic factors, health-related behaviours and clinical measures. Hazards ratios were estimated for every 10-unit increase in PCS or MCS. RESULTS: There were 1052 deaths over a median 4.7-years (interquartile range 3.6-5.7) of follow-up, with 11.9 events per 1000 person-years. Higher PCS was associated with lower all-cause mortality (HR 0.83, 95% CI 0.77, 0.89) in the entire sample, while higher MCS was associated with lower mortality among U.S. participants only (HR 0.78, 95% CI 0.63, 0.95). Gender differences in the association of either PCS or MCS with mortality were not observed. CONCLUSION: Our large study provides evidence that HRQoL is inversely associated with all-cause mortality among initially healthy older people.
Entities:
Keywords:
12-item short form SF-12; Australia; Health-related quality of life; Mortality; Older people; Predictor; Prospective cohort; United States
Authors: Andrea Otero-Rodríguez; Luz María León-Muñoz; Teresa Balboa-Castillo; José R Banegas; Fernando Rodríguez-Artalejo; Pilar Guallar-Castillón Journal: Qual Life Res Date: 2009-11-28 Impact factor: 4.147
Authors: Nigel P Stocks; David A González-Chica; Robyn L Woods; Jessica E Lockery; Rory S J Wolfe; Anne M Murray; Brenda Kirpach; Raj C Shah; Mark R Nelson; Christopher M Reid; Michael E Ernst; John J McNeil Journal: Qual Life Res Date: 2018-11-08 Impact factor: 4.147
Authors: Emily D Williams; Lal Rawal; Brian F Oldenburg; Carla Renwick; Jonathan E Shaw; Robyn J Tapp Journal: Diabetes Care Date: 2012-03-23 Impact factor: 19.112
Authors: Aung Zaw Zaw Phyo; Rosanne Freak-Poli; Heather Craig; Danijela Gasevic; Nigel P Stocks; David A Gonzalez-Chica; Joanne Ryan Journal: BMC Public Health Date: 2020-11-06 Impact factor: 3.295
Authors: Aung Zaw Zaw Phyo; David A Gonzalez-Chica; Nigel P Stocks; Elsdon Storey; Robyn L Woods; Anne M Murray; Suzanne G Orchard; Raj C Shah; Danijela Gasevic; Rosanne Freak-Poli; Joanne Ryan Journal: J Alzheimers Dis Date: 2021 Impact factor: 4.472
Authors: Joanne Ryan; Rosanne Freak-Poli; Aung Zaw Zaw Phyo; David A Gonzalez-Chica; Nigel P Stocks; Robyn L Woods; Jane Fisher; Thach Tran; Alice J Owen; Stephanie A Ward; Carlene J Britt Journal: Qual Life Res Date: 2021-10-22 Impact factor: 3.440
Authors: Jo Wrigglesworth; Ian H Harding; Phillip Ward; Robyn L Woods; Elsdon Storey; Bernadette Fitzgibbon; Gary Egan; Anne Murray; Raj C Shah; Ruth E Trevaks; Stephanie Ward; John J McNeil; Joanne Ryan Journal: J Alzheimers Dis Rep Date: 2022-04-04