Majdi Jber1, Jafar Mehvari Habibabadi2, Roya Sharifpour3,4, Hengameh Marzbani5, Masoud Hassanpour4, Milad Seyfi3,4, Neda Mohammadi Mobarakeh4, Ahmedreza Keihani3, Seyed Sohrab Hashemi-Fesharaki6, Mohammadreza Ay3,4, Mohammad-Reza Nazem-Zadeh7,8. 1. Medical School, International Campus, Tehran University of Medical Sciences, Tehran, Iran. 2. Isfahan Neuroscience Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. 3. Physics and Biomedical Engineering Department, Tehran University of Medical Sciences, Tehran, Iran. 4. Research Center for Molecular and Cellular Imaging, Advanced Medical Technologies and Equipment Institute (AMTEI), Tehran University of Medical Sciences, Tehran, Iran. 5. Department of Biomedical Engineering, Amirkabir University of Technology (AUT), Tehran, Iran. 6. Pars Advanced Medical Research Center, Pars Hospital, Tehran, Iran. 7. Physics and Biomedical Engineering Department, Tehran University of Medical Sciences, Tehran, Iran. mnazemzadeh@tums.ac.ir. 8. Research Center for Molecular and Cellular Imaging, Advanced Medical Technologies and Equipment Institute (AMTEI), Tehran University of Medical Sciences, Tehran, Iran. mnazemzadeh@tums.ac.ir.
Abstract
BACKGROUND: Advances in MRI acquisition and data processing have become important for revealing brain structural changes. Previous studies have reported widespread structural brain abnormalities and cortical thinning in patients with temporal lobe epilepsy (TLE), as the most common form of focal epilepsy. METHODS: In this research, healthy control cases (n = 20) and patients with left TLE (n = 19) and right TLE (n = 14) were recruited, all underwent 3.0 T MRI with magnetization-prepared rapid gradient echo sequence to acquire T1-weighted images. Morphometric alterations in gray matter were identified using voxel-based morphometry (VBM). Volumetric alterations in subcortical structures and cortical thinning were also determined. RESULTS: Patients with left TLE demonstrated more prevailing and widespread changes in subcortical volumes and cortical thickness than right TLE, mainly in the left hemisphere, compared to the healthy group. Both VBM analysis and subcortical volumetry detected significant hippocampal atrophy in ipsilateral compared to contralateral side in TLE group. In addition to hippocampus, subcortical volumetry found the thalamus and pallidum bilaterally vulnerable to the TLE. Furthermore, the TLE patients underwent cortical thinning beyond the temporal lobe, affecting gray matter cortices in frontal, parietal, and occipital lobes in the majority of patients, more prevalently for left TLE cases. Exploiting volume changes in individual patients in the hippocampus alone led to 63.6% sensitivity and 100% specificity for lateralization of TLE. CONCLUSION: Alteration of gray matter volumes in subcortical regions and neocortical temporal structures and also cortical gray matter thickness were evidenced as common effects of epileptogenicity, as manifested by the majority of cases in this study.
BACKGROUND: Advances in MRI acquisition and data processing have become important for revealing brain structural changes. Previous studies have reported widespread structural brain abnormalities and cortical thinning in patients with temporal lobe epilepsy (TLE), as the most common form of focal epilepsy. METHODS: In this research, healthy control cases (n = 20) and patients with left TLE (n = 19) and right TLE (n = 14) were recruited, all underwent 3.0 T MRI with magnetization-prepared rapid gradient echo sequence to acquire T1-weighted images. Morphometric alterations in gray matter were identified using voxel-based morphometry (VBM). Volumetric alterations in subcortical structures and cortical thinning were also determined. RESULTS:Patients with left TLE demonstrated more prevailing and widespread changes in subcortical volumes and cortical thickness than right TLE, mainly in the left hemisphere, compared to the healthy group. Both VBM analysis and subcortical volumetry detected significant hippocampal atrophy in ipsilateral compared to contralateral side in TLE group. In addition to hippocampus, subcortical volumetry found the thalamus and pallidum bilaterally vulnerable to the TLE. Furthermore, the TLEpatients underwent cortical thinning beyond the temporal lobe, affecting gray matter cortices in frontal, parietal, and occipital lobes in the majority of patients, more prevalently for left TLE cases. Exploiting volume changes in individual patients in the hippocampus alone led to 63.6% sensitivity and 100% specificity for lateralization of TLE. CONCLUSION: Alteration of gray matter volumes in subcortical regions and neocortical temporal structures and also cortical gray matter thickness were evidenced as common effects of epileptogenicity, as manifested by the majority of cases in this study.
Authors: Jason P Lerch; André J W van der Kouwe; Armin Raznahan; Tomáš Paus; Heidi Johansen-Berg; Karla L Miller; Stephen M Smith; Bruce Fischl; Stamatios N Sotiropoulos Journal: Nat Neurosci Date: 2017-02-23 Impact factor: 24.884
Authors: Ravindra Arya; Francesco T Mangano; Paul S Horn; Katherine D Holland; Douglas F Rose; Tracy A Glauser Journal: Epilepsia Date: 2013-01-07 Impact factor: 5.864