Literature DB >> 33389160

Steroid-induced rapid recovery from respiratory dysfunction in a patient with myasthenia gravis after spinal anesthesia.

Atsushi Yamashita1, Tamie Takenami2, Mariko Kawabata1, Takahiro Honda1.   

Abstract

We report an 83-year-old man with myasthenia gravis (MG) who developed respiratory depression after spinal anesthesia for transurethral laser enucleation of the prostate. He became less responsive after complained of dyspnea, with a decrease of SpO2 to 83% approximately 13 min after intrathecal administration of 0.5% isobaric bupivacaine 3 ml. With a diagnosis of exacerbation of MG, hydrocortisone 100 mg was administered, following which both consciousness and spontaneous respiration rapidly improved. Cold sense was observed below the C4 dermatome. We provided general anesthesia without using muscle relaxants until disappearance of the effect of spinal anesthesia. Surgery completed uneventfully and confirmed wearing off the local anesthetics effect. He was discharged without respiratory problems on postoperative 3 day.

Entities:  

Keywords:  Myasthenia gravis; Non-genomic effects; Respiratory failure; Spinal anesthesia; Steroid

Mesh:

Substances:

Year:  2021        PMID: 33389160     DOI: 10.1007/s00540-020-02874-9

Source DB:  PubMed          Journal:  J Anesth        ISSN: 0913-8668            Impact factor:   2.078


  2 in total

Review 1.  Multiple actions of steroid hormones--a focus on rapid, nongenomic effects.

Authors:  E Falkenstein; H C Tillmann; M Christ; M Feuring; M Wehling
Journal:  Pharmacol Rev       Date:  2000-12       Impact factor: 25.468

Review 2.  Anesthetic implications of myasthenia gravis.

Authors:  Mark Abel; James B Eisenkraft
Journal:  Mt Sinai J Med       Date:  2002 Jan-Mar
  2 in total

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