Aljoša Mandić1,2, Nemanja Stevanović3, Bojana Gutic3,4, Slobodan Maričić3,4, Zoran Nikin3,4, Nenad Šolajić3,4. 1. Oncology Institute of Vojvodina Sremska Kamenica, Sremska Kamenica, Serbia. aljosa.mandic@mf.uns.ac.rs. 2. Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia. aljosa.mandic@mf.uns.ac.rs. 3. Oncology Institute of Vojvodina Sremska Kamenica, Sremska Kamenica, Serbia. 4. Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia.
Abstract
INTRODUCTION: Cervical intraepithelial neoplasia (CIN) are precancerous lesion of cervix, with incidence of 1.6 per 1000 for CIN 1 lesion and 1.2 per 1000 for CIN 3 lesion in USA. According to IARC incidence is higher in less developed and developing countries. Taking into account the fact that the sensitivity, specificity and accuracy of Papanicolaou swab and colposcopy vary, the final diagnosis is made by colposcopically guided biopsy and by excisions of the cervix. AIM OF THE STUDY: Comparing the histopathological findings of cervical biopsy and definitive histopathological findings after cervical excision in precancerous lesions of the cervix in relation to the degree of lesion, age and institution, where the biopsy was performed. MATERIALS AND METHODS: The study was retrospective and was conducted on a group of patients who underwent some excision techniques on the cervix after obtaining a histological finding of the cervical biopsy. RESULTS: In a total sample of 168 patients, a correlation of histopathological analysis of biopsy material and excision techniques was observed in 62.5% (105/168). This correlation was statistically significant (χ2 = 5.333, df 1; p = 0.0209). The greater correlation of histopathological material of biopsies and final histopathological material after excisions were obtained in Oncology Institute of Vojvodina (OIV) without statistical significance. CONCLUSION: A statistically significant accuracy of biopsy was noted in examined group of patients.
INTRODUCTION: Cervical intraepithelial neoplasia (CIN) are precancerous lesion of cervix, with incidence of 1.6 per 1000 for CIN 1 lesion and 1.2 per 1000 for CIN 3 lesion in USA. According to IARC incidence is higher in less developed and developing countries. Taking into account the fact that the sensitivity, specificity and accuracy of Papanicolaou swab and colposcopy vary, the final diagnosis is made by colposcopically guided biopsy and by excisions of the cervix. AIM OF THE STUDY: Comparing the histopathological findings of cervical biopsy and definitive histopathological findings after cervical excision in precancerous lesions of the cervix in relation to the degree of lesion, age and institution, where the biopsy was performed. MATERIALS AND METHODS: The study was retrospective and was conducted on a group of patients who underwent some excision techniques on the cervix after obtaining a histological finding of the cervical biopsy. RESULTS: In a total sample of 168 patients, a correlation of histopathological analysis of biopsy material and excision techniques was observed in 62.5% (105/168). This correlation was statistically significant (χ2 = 5.333, df 1; p = 0.0209). The greater correlation of histopathological material of biopsies and final histopathological material after excisions were obtained in Oncology Institute of Vojvodina (OIV) without statistical significance. CONCLUSION: A statistically significant accuracy of biopsy was noted in examined group of patients.
Entities:
Keywords:
Cervical biopsy; Excision procedures; Precancerous lesions of cervix
Authors: Frederik A Stuebs; Carla E Schulmeyer; Grit Mehlhorn; Paul Gass; Sven Kehl; Simone K Renner; Stefan P Renner; Carol Geppert; Werner Adler; Arndt Hartmann; Matthias W Beckmann; Martin C Koch Journal: Arch Gynecol Obstet Date: 2018-10-27 Impact factor: 2.344