Literature DB >> 33388419

Leukemic extracellular vesicles induce chimeric antigen receptor T cell dysfunction in chronic lymphocytic leukemia.

Michelle J Cox1, Fabrice Lucien2, Reona Sakemura3, Justin C Boysen4, Yohan Kim2, Paulina Horvei5, Claudia Manriquez Roman6, Michael J Hansen7, Erin E Tapper3, Elizabeth L Siegler3, Cynthia Forsman8, Sydney B Crotts9, Kendall J Schick10, Mehrdad Hefazi3, Michael W Ruff11, Ismail Can12, Mohamad Adada13, Evandro Bezerra13, Lionel Aurelien Kankeu Fonkoua13, Wendy K Nevala7, Esteban Braggio14, Wei Ding4, Sameer A Parikh4, Neil E Kay15, Saad S Kenderian16.   

Abstract

Chimeric antigen receptor (CAR) T cell therapy has yielded unprecedented outcomes in some patients with hematological malignancies; however, inhibition by the tumor microenvironment has prevented the broader success of CART cell therapy. We used chronic lymphocytic leukemia (CLL) as a model to investigate the interactions between the tumor microenvironment and CART cells. CLL is characterized by an immunosuppressive microenvironment, an abundance of systemic extracellular vesicles (EVs), and a relatively lower durable response rate to CART cell therapy. In this study, we characterized plasma EVs from untreated CLL patients and identified their leukemic cell origin. CLL-derived EVs were able to induce a state of CART cell dysfunction characterized by phenotypical, functional, and transcriptional changes of exhaustion. We demonstrate that, specifically, PD-L1+ CLL-derived EVs induce CART cell exhaustion. In conclusion, we identify an important mechanism of CART cell exhaustion induced by EVs from CLL patients.
Copyright © 2020 The American Society of Gene and Cell Therapy. Published by Elsevier Inc. All rights reserved.

Entities:  

Keywords:  CART cell exhaustion; chimeric antigen receptor T cells; chronic lymphocytic leukemia; extracellular vesicles; microenvironment

Mesh：

Substances：

Year:  2021        PMID： 33388419      PMCID： PMC8058445          DOI： 10.1016/j.ymthe.2020.12.033

Source DB:  PubMed          Journal:  Mol Ther        ISSN： 1525-0016            Impact factor:   11.454


  42 in total

1.  Chimeric antigen receptor-modified T cells in chronic lymphoid leukemia.

Authors:  David L Porter; Bruce L Levine; Michael Kalos; Adam Bagg; Carl H June
Journal:  N Engl J Med       Date:  2011-08-10       Impact factor: 91.245

2.  T cells with chimeric antigen receptors have potent antitumor effects and can establish memory in patients with advanced leukemia.

Authors:  Michael Kalos; Bruce L Levine; David L Porter; Sharyn Katz; Stephan A Grupp; Adam Bagg; Carl H June
Journal:  Sci Transl Med       Date:  2011-08-10       Impact factor: 17.956

Review 3.  Exosomes and cancer: From oncogenic roles to therapeutic applications.

Authors:  Soheila Mohammadi; Fatemeh Yousefi; Zahra Shabaninejad; Ahmad Movahedpour; Maryam Mahjoubin Tehran; Alimohammad Shafiee; Sanaz Moradizarmehri; Sarah Hajighadimi; Amir Savardashtaki; Hamed Mirzaei
Journal:  IUBMB Life       Date:  2019-10-16       Impact factor: 3.885

4.  Long-term safety and activity of axicabtagene ciloleucel in refractory large B-cell lymphoma (ZUMA-1): a single-arm, multicentre, phase 1-2 trial.

Authors:  Frederick L Locke; Armin Ghobadi; Caron A Jacobson; David B Miklos; Lazaros J Lekakis; Olalekan O Oluwole; Yi Lin; Ira Braunschweig; Brian T Hill; John M Timmerman; Abhinav Deol; Patrick M Reagan; Patrick Stiff; Ian W Flinn; Umar Farooq; Andre Goy; Peter A McSweeney; Javier Munoz; Tanya Siddiqi; Julio C Chavez; Alex F Herrera; Nancy L Bartlett; Jeffrey S Wiezorek; Lynn Navale; Allen Xue; Yizhou Jiang; Adrian Bot; John M Rossi; Jenny J Kim; William Y Go; Sattva S Neelapu
Journal:  Lancet Oncol       Date:  2018-12-02       Impact factor: 41.316

5.  CD19 CAR-T cells of defined CD4+:CD8+ composition in adult B cell ALL patients.

Authors:  Cameron J Turtle; Laïla-Aïcha Hanafi; Carolina Berger; Theodore A Gooley; Sindhu Cherian; Michael Hudecek; Daniel Sommermeyer; Katherine Melville; Barbara Pender; Tanya M Budiarto; Emily Robinson; Natalia N Steevens; Colette Chaney; Lorinda Soma; Xueyan Chen; Cecilia Yeung; Brent Wood; Daniel Li; Jianhong Cao; Shelly Heimfeld; Michael C Jensen; Stanley R Riddell; David G Maloney
Journal:  J Clin Invest       Date:  2016-04-25       Impact factor: 14.808

6.  CX3CR1 identifies PD-1 therapy-responsive CD8+ T cells that withstand chemotherapy during cancer chemoimmunotherapy.

Authors:  Yiyi Yan; Siyu Cao; Xin Liu; Susan M Harrington; Wendy E Bindeman; Alex A Adjei; Jin Sung Jang; Jin Jen; Ying Li; Pritha Chanana; Aaron S Mansfield; Sean S Park; Svetomir N Markovic; Roxana S Dronca; Haidong Dong
Journal:  JCI Insight       Date:  2018-04-19

7.  Tumour-derived exosomes and their role in cancer-associated T-cell signalling defects.

Authors:  D D Taylor; C Gerçel-Taylor
Journal:  Br J Cancer       Date:  2005-01-31       Impact factor: 7.640

8.  Dynamics of microvesicle generation in B-cell chronic lymphocytic leukemia: implication in disease progression.

Authors:  J Boysen; M Nelson; G Magzoub; G P Maiti; S Sinha; M Goswami; S K Vesely; T D Shanafelt; N E Kay; A K Ghosh
Journal:  Leukemia       Date:  2016-08-02       Impact factor: 11.528

9.  Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines.

Authors:  Clotilde Théry; Kenneth W Witwer; Elena Aikawa; Maria Jose Alcaraz; Johnathon D Anderson; Ramaroson Andriantsitohaina; Anna Antoniou; Tanina Arab; Fabienne Archer; Georgia K Atkin-Smith; D Craig Ayre; Jean-Marie Bach; Daniel Bachurski; Hossein Baharvand; Leonora Balaj; Shawn Baldacchino; Natalie N Bauer; Amy A Baxter; Mary Bebawy; Carla Beckham; Apolonija Bedina Zavec; Abderrahim Benmoussa; Anna C Berardi; Paolo Bergese; Ewa Bielska; Cherie Blenkiron; Sylwia Bobis-Wozowicz; Eric Boilard; Wilfrid Boireau; Antonella Bongiovanni; Francesc E Borràs; Steffi Bosch; Chantal M Boulanger; Xandra Breakefield; Andrew M Breglio; Meadhbh Á Brennan; David R Brigstock; Alain Brisson; Marike Ld Broekman; Jacqueline F Bromberg; Paulina Bryl-Górecka; Shilpa Buch; Amy H Buck; Dylan Burger; Sara Busatto; Dominik Buschmann; Benedetta Bussolati; Edit I Buzás; James Bryan Byrd; Giovanni Camussi; David Rf Carter; Sarah Caruso; Lawrence W Chamley; Yu-Ting Chang; Chihchen Chen; Shuai Chen; Lesley Cheng; Andrew R Chin; Aled Clayton; Stefano P Clerici; Alex Cocks; Emanuele Cocucci; Robert J Coffey; Anabela Cordeiro-da-Silva; Yvonne Couch; Frank Aw Coumans; Beth Coyle; Rossella Crescitelli; Miria Ferreira Criado; Crislyn D'Souza-Schorey; Saumya Das; Amrita Datta Chaudhuri; Paola de Candia; Eliezer F De Santana; Olivier De Wever; Hernando A Del Portillo; Tanguy Demaret; Sarah Deville; Andrew Devitt; Bert Dhondt; Dolores Di Vizio; Lothar C Dieterich; Vincenza Dolo; Ana Paula Dominguez Rubio; Massimo Dominici; Mauricio R Dourado; Tom Ap Driedonks; Filipe V Duarte; Heather M Duncan; Ramon M Eichenberger; Karin Ekström; Samir El Andaloussi; Celine Elie-Caille; Uta Erdbrügger; Juan M Falcón-Pérez; Farah Fatima; Jason E Fish; Miguel Flores-Bellver; András Försönits; Annie Frelet-Barrand; Fabia Fricke; Gregor Fuhrmann; Susanne Gabrielsson; Ana Gámez-Valero; Chris Gardiner; Kathrin Gärtner; Raphael Gaudin; Yong Song Gho; Bernd Giebel; Caroline Gilbert; Mario Gimona; Ilaria Giusti; Deborah Ci Goberdhan; André Görgens; Sharon M Gorski; David W Greening; Julia Christina Gross; Alice Gualerzi; Gopal N Gupta; Dakota Gustafson; Aase Handberg; Reka A Haraszti; Paul Harrison; Hargita Hegyesi; An Hendrix; Andrew F Hill; Fred H Hochberg; Karl F Hoffmann; Beth Holder; Harry Holthofer; Baharak Hosseinkhani; Guoku Hu; Yiyao Huang; Veronica Huber; Stuart Hunt; Ahmed Gamal-Eldin Ibrahim; Tsuneya Ikezu; Jameel M Inal; Mustafa Isin; Alena Ivanova; Hannah K Jackson; Soren Jacobsen; Steven M Jay; Muthuvel Jayachandran; Guido Jenster; Lanzhou Jiang; Suzanne M Johnson; Jennifer C Jones; Ambrose Jong; Tijana Jovanovic-Talisman; Stephanie Jung; Raghu Kalluri; Shin-Ichi Kano; Sukhbir Kaur; Yumi Kawamura; Evan T Keller; Delaram Khamari; Elena Khomyakova; Anastasia Khvorova; Peter Kierulf; Kwang Pyo Kim; Thomas Kislinger; Mikael Klingeborn; David J Klinke; Miroslaw Kornek; Maja M Kosanović; Árpád Ferenc Kovács; Eva-Maria Krämer-Albers; Susanne Krasemann; Mirja Krause; Igor V Kurochkin; Gina D Kusuma; Sören Kuypers; Saara Laitinen; Scott M Langevin; Lucia R Languino; Joanne Lannigan; Cecilia Lässer; Louise C Laurent; Gregory Lavieu; Elisa Lázaro-Ibáñez; Soazig Le Lay; Myung-Shin Lee; Yi Xin Fiona Lee; Debora S Lemos; Metka Lenassi; Aleksandra Leszczynska; Isaac Ts Li; Ke Liao; Sten F Libregts; Erzsebet Ligeti; Rebecca Lim; Sai Kiang Lim; Aija Linē; Karen Linnemannstöns; Alicia Llorente; Catherine A Lombard; Magdalena J Lorenowicz; Ákos M Lörincz; Jan Lötvall; Jason Lovett; Michelle C Lowry; Xavier Loyer; Quan Lu; Barbara Lukomska; Taral R Lunavat; Sybren Ln Maas; Harmeet Malhi; Antonio Marcilla; Jacopo Mariani; Javier Mariscal; Elena S Martens-Uzunova; Lorena Martin-Jaular; M Carmen Martinez; Vilma Regina Martins; Mathilde Mathieu; Suresh Mathivanan; Marco Maugeri; Lynda K McGinnis; Mark J McVey; David G Meckes; Katie L Meehan; Inge Mertens; Valentina R Minciacchi; Andreas Möller; Malene Møller Jørgensen; Aizea Morales-Kastresana; Jess Morhayim; François Mullier; Maurizio Muraca; Luca Musante; Veronika Mussack; Dillon C Muth; Kathryn H Myburgh; Tanbir Najrana; Muhammad Nawaz; Irina Nazarenko; Peter Nejsum; Christian Neri; Tommaso Neri; Rienk Nieuwland; Leonardo Nimrichter; John P Nolan; Esther Nm Nolte-'t Hoen; Nicole Noren Hooten; Lorraine O'Driscoll; Tina O'Grady; Ana O'Loghlen; Takahiro Ochiya; Martin Olivier; Alberto Ortiz; Luis A Ortiz; Xabier Osteikoetxea; Ole Østergaard; Matias Ostrowski; Jaesung Park; D Michiel Pegtel; Hector Peinado; Francesca Perut; Michael W Pfaffl; Donald G Phinney; Bartijn Ch Pieters; Ryan C Pink; David S Pisetsky; Elke Pogge von Strandmann; Iva Polakovicova; Ivan Kh Poon; Bonita H Powell; Ilaria Prada; Lynn Pulliam; Peter Quesenberry; Annalisa Radeghieri; Robert L Raffai; Stefania Raimondo; Janusz Rak; Marcel I Ramirez; Graça Raposo; Morsi S Rayyan; Neta Regev-Rudzki; Franz L Ricklefs; Paul D Robbins; David D Roberts; Silvia C Rodrigues; Eva Rohde; Sophie Rome; Kasper Ma Rouschop; Aurelia Rughetti; Ashley E Russell; Paula Saá; Susmita Sahoo; Edison Salas-Huenuleo; Catherine Sánchez; Julie A Saugstad; Meike J Saul; Raymond M Schiffelers; Raphael Schneider; Tine Hiorth Schøyen; Aaron Scott; Eriomina Shahaj; Shivani Sharma; Olga Shatnyeva; Faezeh Shekari; Ganesh Vilas Shelke; Ashok K Shetty; Kiyotaka Shiba; Pia R-M Siljander; Andreia M Silva; Agata Skowronek; Orman L Snyder; Rodrigo Pedro Soares; Barbara W Sódar; Carolina Soekmadji; Javier Sotillo; Philip D Stahl; Willem Stoorvogel; Shannon L Stott; Erwin F Strasser; Simon Swift; Hidetoshi Tahara; Muneesh Tewari; Kate Timms; Swasti Tiwari; Rochelle Tixeira; Mercedes Tkach; Wei Seong Toh; Richard Tomasini; Ana Claudia Torrecilhas; Juan Pablo Tosar; Vasilis Toxavidis; Lorena Urbanelli; Pieter Vader; Bas Wm van Balkom; Susanne G van der Grein; Jan Van Deun; Martijn Jc van Herwijnen; Kendall Van Keuren-Jensen; Guillaume van Niel; Martin E van Royen; Andre J van Wijnen; M Helena Vasconcelos; Ivan J Vechetti; Tiago D Veit; Laura J Vella; Émilie Velot; Frederik J Verweij; Beate Vestad; Jose L Viñas; Tamás Visnovitz; Krisztina V Vukman; Jessica Wahlgren; Dionysios C Watson; Marca Hm Wauben; Alissa Weaver; Jason P Webber; Viktoria Weber; Ann M Wehman; Daniel J Weiss; Joshua A Welsh; Sebastian Wendt; Asa M Wheelock; Zoltán Wiener; Leonie Witte; Joy Wolfram; Angeliki Xagorari; Patricia Xander; Jing Xu; Xiaomei Yan; María Yáñez-Mó; Hang Yin; Yuana Yuana; Valentina Zappulli; Jana Zarubova; Vytautas Žėkas; Jian-Ye Zhang; Zezhou Zhao; Lei Zheng; Alexander R Zheutlin; Antje M Zickler; Pascale Zimmermann; Angela M Zivkovic; Davide Zocco; Ewa K Zuba-Surma
Journal:  J Extracell Vesicles       Date:  2018-11-23

Review 10.  Emerging roles and therapeutic value of exosomes in cancer metastasis.

Authors:  Miaowei Wu; Guosheng Wang; Weilei Hu; Yihan Yao; Xiao-Fang Yu
Journal:  Mol Cancer       Date:  2019-03-30       Impact factor: 27.401
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Authors:  Yuan-Yuan Hao; Pan-Pan Chen; Xiang-Gui Yuan; Ai-Qi Zhao; Yun Liang; Hui Liu; Wen-Bin Qian
Journal:  World J Clin Cases       Date:  2022-07-06       Impact factor: 1.534

Review 2.  CAR T Cell Therapy for Chronic Lymphocytic Leukemia: Successes and Shortcomings.

Authors:  Zeljko Todorovic; Dusan Todorovic; Vladimir Markovic; Nevena Ladjevac; Natasa Zdravkovic; Predrag Djurdjevic; Nebojsa Arsenijevic; Marija Milovanovic; Aleksandar Arsenijevic; Jelena Milovanovic
Journal:  Curr Oncol       Date:  2022-05-18       Impact factor: 3.109

3.  A Specific CD44lo CD25lo Subpopulation of Regulatory T Cells Inhibits Anti-Leukemic Immune Response and Promotes the Progression in a Mouse Model of Chronic Lymphocytic Leukemia.

Authors:  Agnieszka Goral; Malgorzata Firczuk; Klaudyna Fidyt; Marta Sledz; Francesca Simoncello; Karolina Siudakowska; Giulia Pagano; Etienne Moussay; Jérôme Paggetti; Patrycja Nowakowska; Stefania Gobessi; Joanna Barankiewicz; Aleksander Salomon-Perzynski; Federica Benvenuti; Dimitar G Efremov; Przemyslaw Juszczynski; Ewa Lech-Maranda; Angelika Muchowicz
Journal:  Front Immunol       Date:  2022-02-28       Impact factor: 7.561

Review 4.  CAR T cell therapy and the tumor microenvironment: Current challenges and opportunities.

Authors:  Lionel A Kankeu Fonkoua; Olivia Sirpilla; Reona Sakemura; Elizabeth L Siegler; Saad S Kenderian
Journal:  Mol Ther Oncolytics       Date:  2022-03-19       Impact factor: 7.200

5.  CLL-Derived Extracellular Vesicles Impair T-Cell Activation and Foster T-Cell Exhaustion via Multiple Immunological Checkpoints.

Authors:  Martin Böttcher; Romy Böttcher-Loschinski; Sascha Kahlfuss; Michael Aigner; Andreas Gießl; Andreas Mackensen; Ursula Schlötzer-Schrehardt; Thomas Tüting; Heiko Bruns; Dimitrios Mougiakakos
Journal:  Cells       Date:  2022-07-12       Impact factor: 7.666

Review 6.  Extracellular Vesicles in Haematological Disorders: A Friend or a Foe?

Authors:  Ioanna Lazana
Journal:  Int J Mol Sci       Date:  2022-09-04       Impact factor: 6.208

Review 7.  Emerging roles of extracellular vesicles in normal and malignant hematopoiesis.

Authors:  Guohuan Sun; Quan Gu; Junke Zheng; Hui Cheng; Tao Cheng
Journal:  J Clin Invest       Date:  2022-09-15       Impact factor: 19.456

Review 8.  The significance of exosomal RNAs in the development, diagnosis, and treatment of pancreatic cancer.

Authors:  Zheng Zhao; Guiping Zhao; Shuyue Yang; Shengtao Zhu; Shutian Zhang; Peng Li
Journal:  Cancer Cell Int       Date:  2021-07-09       Impact factor: 5.722

9.  Development of a Clinically Relevant Reporter for Chimeric Antigen Receptor T-cell Expansion, Trafficking, and Toxicity.

Authors:  Reona Sakemura; Aditya Bansal; Elizabeth L Siegler; Mehrdad Hefazi; Nan Yang; Roman H Khadka; Alysha N Newsom; Michael J Hansen; Michelle J Cox; Claudia Manriquez Roman; Kendall J Schick; Ismail Can; Erin E Tapper; Wendy K Nevala; Mohamad M Adada; Evandro D Bezerra; Lionel Aurelien Kankeu Fonkoua; Paulina Horvei; Michael W Ruff; Sameer A Parikh; Mukesh K Pandey; Timothy R DeGrado; Lukkana Suksanpaisan; Neil E Kay; Kah-Whye Peng; Stephen J Russell; Saad S Kenderian
Journal:  Cancer Immunol Res       Date:  2021-07-08       Impact factor: 12.020
  9 in total

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