Shoko Nozaki1,2, Norie Sawada3, Yutaka J Matsuoka4, Ryo Shikimoto1, Masaru Mimura1, Shoichiro Tsugane3. 1. Department of Neuropsychiatry, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan. 2. Department of Psychiatry, National Hospital Organization Shimofusa Psychiatric Medical Center, Midori-ku, Chiba-city, Chiba, Japan. 3. Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center Japan, Chuo-ku, Tokyo, Japan. 4. Division of Health Care Research, Center for Public Health Sciences, National Cancer Center Japan, Chuo-ku, Tokyo, Japan.
Abstract
BACKGROUND: The relationship between midlife dietary habits and risk of dementia remains unclear. OBJECTIVE: To investigate the association between dietary fish and n-3 polyunsaturated fatty acid (PUFA) consumption in midlife and risk of dementia in later life. METHODS: This population-based cohort study assessed food frequency (average intake in 1995 and 2000) and cognition (2014-2015) in 1,127 participants (aged 45-64 in 1995). We used logistic regression analyses to calculate odds ratios (ORs) for dementia and mild cognitive impairment (MCI) diagnoses for consumption quartiles of fish, PUFA-rich fish, total n-3 PUFAs, total n-6 PUFAs, types of PUFAs, and n-3/n-6 PUFA ratio. Estimated ORs were adjusted for age; sex; education; smoking status; alcohol consumption frequency; physical activity; histories of cancer, myocardial infarction, and diabetes mellitus; and depression. RESULTS: Significantly reduced risks of dementia over non-dementia (MCI plus cognitively normal) were observed in the second (OR = 0.43 (95%CI = 0.20-0.93)), third (OR = 0.22 (95%CI = 0.09-0.54)), and highest quartiles (OR = 0.39 (95%CI = 0.18-0.86)) for fish; the third (OR = 0.39(95%CI = 0.16-0.92)) and highest quartiles (OR = 0.44(95%CI = 0.19-0.98)) for eicosapentaenoic acid (EPA); the second (OR = 0.39(95%CI = 0.18-0.84)), third (OR = 0.30(95%CI = 0.13-0.70)), and highest quartiles (OR = 0.28(95%CI = 0.12-0.66)) for docosahexaenoic acid (DHA); and the third (OR = 0.36 (95%CI = 0.16-0.85)) and highest quartiles (OR = 0.42 (95%CI = 0.19-0.95)) for docosapentaenoic acid (DPA). CONCLUSION: High intake of fish in midlife might aid in preventing dementia.
BACKGROUND: The relationship between midlife dietary habits and risk of dementia remains unclear. OBJECTIVE: To investigate the association between dietary fish and n-3 polyunsaturated fatty acid (PUFA) consumption in midlife and risk of dementia in later life. METHODS: This population-based cohort study assessed food frequency (average intake in 1995 and 2000) and cognition (2014-2015) in 1,127 participants (aged 45-64 in 1995). We used logistic regression analyses to calculate odds ratios (ORs) for dementia and mild cognitive impairment (MCI) diagnoses for consumption quartiles of fish, PUFA-rich fish, total n-3 PUFAs, total n-6 PUFAs, types of PUFAs, and n-3/n-6 PUFA ratio. Estimated ORs were adjusted for age; sex; education; smoking status; alcohol consumption frequency; physical activity; histories of cancer, myocardial infarction, and diabetes mellitus; and depression. RESULTS: Significantly reduced risks of dementia over non-dementia (MCI plus cognitively normal) were observed in the second (OR = 0.43 (95%CI = 0.20-0.93)), third (OR = 0.22 (95%CI = 0.09-0.54)), and highest quartiles (OR = 0.39 (95%CI = 0.18-0.86)) for fish; the third (OR = 0.39(95%CI = 0.16-0.92)) and highest quartiles (OR = 0.44(95%CI = 0.19-0.98)) for eicosapentaenoic acid (EPA); the second (OR = 0.39(95%CI = 0.18-0.84)), third (OR = 0.30(95%CI = 0.13-0.70)), and highest quartiles (OR = 0.28(95%CI = 0.12-0.66)) for docosahexaenoic acid (DHA); and the third (OR = 0.36 (95%CI = 0.16-0.85)) and highest quartiles (OR = 0.42 (95%CI = 0.19-0.95)) for docosapentaenoic acid (DPA). CONCLUSION: High intake of fish in midlife might aid in preventing dementia.