Daniel Schebela Mazzoleni1, Felipe Mazzoleni1,2, Luiz Edmundo Mazzoleni1,3,4, Carlos Fernando de Magalhães Francesconi1,3,4, Tobias Cancian Milbradt1,5, Diego Mendonça Uchoa6, Heitor Ribeiro Birnfeld7, Luiza Vitelo Andrighetto1, Sacha Allebrandt da Silva Ries8, Daniel Simon9, Nicholas Joseph Talley10. 1. Graduate Program Sciences in Gastroenterology and Hepatology, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil. 2. Department of Internal Medicine, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil. 3. Department of Gastroenterology, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil. 4. Department of Internal Medicine, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil. 5. Clinical Research Unit, Hospital Ernesto Dornelles, Porto Alegre, Brazil. 6. Department of Pathology, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil. 7. Hospital Santa Rita de Porto Alegre, Porto Alegre, Brazil. 8. School of Medicine, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil. 9. Human Molecular Genetics Laboratory, Universidade Luterana do Brasil, Canoas, Brazil. 10. Faculty of Health and Medicine, University of Newcastle, Newcastle, Australia.
Abstract
OBJECTIVES: To evaluate the role of Helicobacter pylori and other risk factors in recurrent aphthous stomatitis (RAS). METHODS: Patients with functional dyspepsia responded to questionnaires regarding demographic and clinical data, anxiety and depression, and a specific RAS questionnaire. They underwent upper digestive endoscopy and H. pylori evaluation. RESULTS: 476 patients were included and of the 372 evaluated for H. pylori, 65.6% were H. pylori-positive. RAS was reported by 32.6% (155/476). In the bivariate analysis of the 372 patients evaluated for gastric H. pylori status, positive subjects had a lower RAS prevalence (29.9%; 73/244) than H. pylori-negative (41.4%; 53/128) (p = .026). Smoking (p = .005) and older age (p = .034) were also associated with a lower prevalence, while female gender (p = .032) and lower income (p = .046) presented higher RAS prevalence. In the multivariate analysis, H. pylori infection (p = .017), smoking (p = .001), and older age (p = .013) were protective factors, while lower income (p = .030) and anxiety (p = .042) were risk factors. In the multivariate analysis of all patients, female gender, lower income, and more schooling years were risk factors. CONCLUSIONS: An unexpected lower prevalence of RAS was found in H. pylori-positive patients. Smoking, sex, age, income, education, and anxiety were associated with RAS.
OBJECTIVES: To evaluate the role of Helicobacter pylori and other risk factors in recurrent aphthous stomatitis (RAS). METHODS: Patients with functional dyspepsia responded to questionnaires regarding demographic and clinical data, anxiety and depression, and a specific RAS questionnaire. They underwent upper digestive endoscopy and H. pylori evaluation. RESULTS: 476 patients were included and of the 372 evaluated for H. pylori, 65.6% were H. pylori-positive. RAS was reported by 32.6% (155/476). In the bivariate analysis of the 372 patients evaluated for gastric H. pylori status, positive subjects had a lower RAS prevalence (29.9%; 73/244) than H. pylori-negative (41.4%; 53/128) (p = .026). Smoking (p = .005) and older age (p = .034) were also associated with a lower prevalence, while female gender (p = .032) and lower income (p = .046) presented higher RAS prevalence. In the multivariate analysis, H. pylori infection (p = .017), smoking (p = .001), and older age (p = .013) were protective factors, while lower income (p = .030) and anxiety (p = .042) were risk factors. In the multivariate analysis of all patients, female gender, lower income, and more schooling years were risk factors. CONCLUSIONS: An unexpected lower prevalence of RAS was found in H. pylori-positive patients. Smoking, sex, age, income, education, and anxiety were associated with RAS.