Bethany Stennett1, Molly B Anderson2, Darya Vitus1, Erin Ferguson1, Jesse Dallery2, Meryl Alappattu3, Michael Robinson1, Jeff Boissoneault4. 1. Department of Clinical and Health Psychology, University of Florida, PO Box 100165, Gainesville, FL, 32610, United States; Center for Pain Research and Behavioral Health, University of Florida, PO Box 100165, Gainesville, FL, 32610, United States. 2. Department of Psychology, University of Florida, PO Box 112250, Gainesville, FL, 32611, United States. 3. Center for Pain Research and Behavioral Health, University of Florida, PO Box 100165, Gainesville, FL, 32610, United States; Department of Physical Therapy, University of Florida, PO Box 100154, Gainesville, FL, 32610, United States. 4. Department of Clinical and Health Psychology, University of Florida, PO Box 100165, Gainesville, FL, 32610, United States; Center for Pain Research and Behavioral Health, University of Florida, PO Box 100165, Gainesville, FL, 32610, United States. Electronic address: jboissoneault@phhp.ufl.edu.
Abstract
BACKGROUND: Pain may serve as an antecedent for alcohol use, increasing risk for hazardous drinking and associated consequences. Delayed onset muscle soreness (DOMS) induction produces clinically relevant but time-limited musculoskeletal pain. This study was conducted to determine whether DOMS induction on the dominant elbow flexors influenced alcohol demand using the Alcohol Purchase Task (APT). We hypothesized DOMS would increase alcohol demand relative to a sham control. Based on existing studies of pain self-medication, we expected DOMS-related increases in alcohol demand would be greatest in men. METHODS: Participants (N = 53; 57 % women) were randomly assigned to a DOMS (eccentric exercise) or sham condition (concentric exercise). Participants completed the APT pre-exercise and 48 -hs post-exercise. Repeated measures GLM was used to characterize group by sex by time interactions on APT indices, including intensity, breakpoint, essential value (EV), Omax, and Pmax. RESULTS: The DOMS procedure significantly increased pain ratings at the elbow flexors. Men had significantly higher demand intensity than women across groups and time points. Significant interactive effects were detected for breakpoint and EV. From pre- to post-test, breakpoint significantly increased in men in the DOMS group. However, breakpoint and EV significantly decreased in women in the DOMS group. CONCLUSIONS: Increased alcohol demand in men in the DOMS group was consistent with epidemiological data suggesting men are at higher risk for self-medicating pain with alcohol than women. However, decreased demand in women was unexpected. Taken together, results indicate DOMS induction may be a useful means to characterize pain as an antecedent for alcohol use.
BACKGROUND: Pain may serve as an antecedent for alcohol use, increasing risk for hazardous drinking and associated consequences. Delayed onset muscle soreness (DOMS) induction produces clinically relevant but time-limited musculoskeletal pain. This study was conducted to determine whether DOMS induction on the dominant elbow flexors influenced alcohol demand using the Alcohol Purchase Task (APT). We hypothesized DOMS would increase alcohol demand relative to a sham control. Based on existing studies of pain self-medication, we expected DOMS-related increases in alcohol demand would be greatest in men. METHODS: Participants (N = 53; 57 % women) were randomly assigned to a DOMS (eccentric exercise) or sham condition (concentric exercise). Participants completed the APT pre-exercise and 48 -hs post-exercise. Repeated measures GLM was used to characterize group by sex by time interactions on APT indices, including intensity, breakpoint, essential value (EV), Omax, and Pmax. RESULTS: The DOMS procedure significantly increased pain ratings at the elbow flexors. Men had significantly higher demand intensity than women across groups and time points. Significant interactive effects were detected for breakpoint and EV. From pre- to post-test, breakpoint significantly increased in men in the DOMS group. However, breakpoint and EV significantly decreased in women in the DOMS group. CONCLUSIONS: Increased alcohol demand in men in the DOMS group was consistent with epidemiological data suggesting men are at higher risk for self-medicating pain with alcohol than women. However, decreased demand in women was unexpected. Taken together, results indicate DOMS induction may be a useful means to characterize pain as an antecedent for alcohol use.
Authors: R W Wilsnack; N D Vogeltanz; S C Wilsnack; T R Harris; S Ahlström; S Bondy; L Csémy; R Ferrence; J Ferris; J Fleming; K Graham; T Greenfield; L Guyon; E Haavio-Mannila; F Kellner; R Knibbe; L Kubicka; M Loukomskaia; H Mustonen; L Nadeau; A Narusk; R Neve; G Rahav; F Spak; M Teichman; K Trocki; I Webster; S Weiss Journal: Addiction Date: 2000-02 Impact factor: 6.526
Authors: Darya Vitus; Michelle K Williams; Mehdi Rizk; John K Neubert; Michael Robinson; Jeff Boissoneault Journal: Alcohol Clin Exp Res Date: 2022-08-22 Impact factor: 3.928
Authors: Erin Ferguson; Andrew Fiore; Ali M Yurasek; Robert L Cook; Jeff Boissoneault Journal: Exp Clin Psychopharmacol Date: 2022-02-24 Impact factor: 3.492