Lee Smith1, Louis Jacob2, Karel Kostev3, Laurie Butler4, Yvonne Barnett5, Briona Pfeifer6, Pinar Soysal7, Igor Grabovac8, Guillermo F López-Sánchez9, Nicola Veronese10, Lin Yang11, Hans Oh12, Ai Koyanagi13. 1. The Cambridge Centre for Sport and Exercise Sciences, Anglia Ruskin University, Cambridge, UK. Electronic address: Lee.Smith@aru.ac.uk. 2. Faculty of Medicine, University of Versailles Saint-Quentin-en-Yvelines, Montigny-le-Bretonneux 78180, France; Research and Development Unit, Parc Sanitari Sant Joan de Déu, CIBERSAM, 08830 Barcelona, Spain. 3. University Clinic of Marburg, Marburg, Germany. 4. Faculty of Science and Engineering, Anglia Ruskin University, Cambridge, UK. 5. Anglia Ruskin University, Cambridge, UK. 6. The Cambridge Centre for Sport and Exercise Sciences, Anglia Ruskin University, Cambridge, UK. 7. Department of Geriatric Medicine, Faculty of Medicine, Bezmialem Vakif University, Istanbul, Turkey. 8. Department of Social and Preventive Medicine, Centre for Public Health, Medical University of Vienna, Vienna, Austria. 9. Vision and Eye Research Institute, School of Medicine, Faculty of Health, Education, Medicine and Social Care, Anglia Ruskin University-Cambridge Campus, Cambridge, UK. 10. Geriatric Unit, Department of Internal Medicine and Geriatrics, University of Palermo, Palermo, Italy. 11. Department of Cancer Epidemiology and Prevention Research, Cancer Care Alberta, Alberta Health Services, Calgary, Canada; Departments of Oncology and Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, Canada. 12. School of Social Work, University of Southern California, Los Angeles, CA, USA. 13. Research and Development Unit, Parc Sanitari Sant Joan de Déu, CIBERSAM, 08830 Barcelona, Spain; ICREA, Pg. Lluis Companys 23, 08010 Barcelona, Spain.
Abstract
OBJECTIVES: There is a scarcity of data on the association between mild cognitive impairment (MCI) and falls, especially from low- and middle-income countries (LMICs) where 70% of all older adults reside. Thus, we investigated the association between MCI and fall-related injury among older adults residing in six LMICs (China, Ghana, India, Mexico, Russia, South Africa). DESIGN: Cross-sectional, community-based data from the WHO Study on global AGEing and adult health (SAGE) were analyzed. METHODS: The definition of MCI was based on the National Institute on Ageing-Alzheimer's Association criteria, and information on past 12-month fall-related injury was also collected. Multivariable logistic regression analysis was conducted to assess associations. RESULTS: The analytical sample consisted of 13,623 individuals aged ≥65 years [mean (SD) age 72.3 (10.9) years; 45.6% males]. The prevalence of fall-related injury was higher among those with MCI (6.3%) vs. no MCI (4.1%). After adjustment for potential confounders, MCI was associated with a 1.53 (95%CI = 1.12-2.07) times higher odds for fall-related injury. CONCLUSIONS: MCI was associated with higher odds for fall-related injury among older adults in LMICs. Future studies are warranted to investigate the mechanisms underlying this association and to elucidate whether targeting those with MCI can lead to reduced risk for falls among older adults.
OBJECTIVES: There is a scarcity of data on the association between mild cognitive impairment (MCI) and falls, especially from low- and middle-income countries (LMICs) where 70% of all older adults reside. Thus, we investigated the association between MCI and fall-related injury among older adults residing in six LMICs (China, Ghana, India, Mexico, Russia, South Africa). DESIGN: Cross-sectional, community-based data from the WHO Study on global AGEing and adult health (SAGE) were analyzed. METHODS: The definition of MCI was based on the National Institute on Ageing-Alzheimer's Association criteria, and information on past 12-month fall-related injury was also collected. Multivariable logistic regression analysis was conducted to assess associations. RESULTS: The analytical sample consisted of 13,623 individuals aged ≥65 years [mean (SD) age 72.3 (10.9) years; 45.6% males]. The prevalence of fall-related injury was higher among those with MCI (6.3%) vs. no MCI (4.1%). After adjustment for potential confounders, MCI was associated with a 1.53 (95%CI = 1.12-2.07) times higher odds for fall-related injury. CONCLUSIONS: MCI was associated with higher odds for fall-related injury among older adults in LMICs. Future studies are warranted to investigate the mechanisms underlying this association and to elucidate whether targeting those with MCI can lead to reduced risk for falls among older adults.
Authors: Alex Baby Paul; Dakshin Sitaram Padmanabhan; Vineeth Suresh; Sunav Nellai Nayagam; Niveditha Kartha; George Paul; Priya Vijayakumar Journal: J Family Med Prim Care Date: 2022-03-18