Kan Ding1, Takashi Tarumi2,3, Tsubasa Tomoto2, Kathleen R Bell4, Christopher Madden5, Marisara Dieppa1, C Munro Cullum1,5,6, Song Zhang7, Rong Zhang1,2. 1. Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX, USA. 2. Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital Dallas, Dallas, TX, USA. 3. Human Informatics Research Institute, National Institute of Advanced Industrial Science and Technology, Tsukuba, Japan. 4. Department of Physical Medicine and Rehabilitation, University of Texas Southwestern Medical Center, Dallas, TX, USA. 5. Department of Neurosurgery, University of Texas Southwestern Medical Center, Dallas, TX, USA. 6. Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA. 7. Department of Population and Data Sciences, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Abstract
Objective: To assess the feasibility of conducting an aerobic exercise training study in a community setting for individuals with traumatic brain injury (TBI) Methods: This is a prospective, randomized, and controlled study. Nine participants (three moderate-to-severe and six mild TBI) were randomized to a community-based 3-month individualized aerobic exercise training program (AET). Seven participants (four moderate-to-severe, three mild TBI) were randomized to a stretching and toning program (SAT). Cardiorespiratory fitness (CRF) level was assessed with peak oxygen uptake (VO2peak) testing. Results: After 3 months of training, the AET trended toward improved VO2peak when compared with the SAT group (8% vs - 4%, p = .059) with a large effect size of 1.27. Only 50% of participants in the AET group completed more than 70% of the assigned exercise sessions. No adverse events were reported. Both the AET and SAT groups reported small improvements in self-reported mood symptoms, including depression, anxiety, and anger.Conclusions: It is feasible to conduct an exercise training study and improve CRF for persons with TBI in community settings with structured exercise protocols. However, exploring methods to enhance adherence is crucial for future exercise clinical trials to improve brain health in this population.
RCT Entities:
Objective: To assess the feasibility of conducting an aerobic exercise training study in a community setting for individuals with traumatic brain injury (TBI) Methods: This is a prospective, randomized, and controlled study. Nine participants (three moderate-to-severe and six mild TBI) were randomized to a community-based 3-month individualized aerobic exercise training program (AET). Seven participants (four moderate-to-severe, three mild TBI) were randomized to a stretching and toning program (SAT). Cardiorespiratory fitness (CRF) level was assessed with peak oxygen uptake (VO2peak) testing. Results: After 3 months of training, the AET trended toward improved VO2peak when compared with the SAT group (8% vs - 4%, p = .059) with a large effect size of 1.27. Only 50% of participants in the AET group completed more than 70% of the assigned exercise sessions. No adverse events were reported. Both the AET and SAT groups reported small improvements in self-reported mood symptoms, including depression, anxiety, and anger.Conclusions: It is feasible to conduct an exercise training study and improve CRF for persons with TBI in community settings with structured exercise protocols. However, exploring methods to enhance adherence is crucial for future exercise clinical trials to improve brain health in this population.
Authors: Kan Ding; Shannon B Juengst; Stephanie Neaves; Ahmad Turki; Chaowei Wang; Mu Huang; Tri Pham; Khosrow Behbehani; Ming Li; Linda Hynan; Simon Driver; Rong Zhang; Kathleen R Bell Journal: Brain Inj Date: 2022-04-04 Impact factor: 2.167