Literature DB >> 33385253

RANKL as the master regulator of osteoclast differentiation.

Hiroshi Takayanagi1.   

Abstract

RANKL, the essential cue for osteoclast differentiation, is the membrane-bound factor expressed by osteoclastogenesis-supporting cells such as osteoblasts and osteocytes. In vivo evidence indicates that RANKL functions as the indispensable and irreplaceable in the program of osteoclast differentiation. The reason why RANKL plays a critical role in osteoclastogenesis is discussed from the viewpoint of the distinct signaling pathways mediated by co-stimulatory receptors and the key transcription factor NFATc1.

Entities:  

Keywords:  OPG; Osteoclasts; Osteoimmunology; RANK; RANKL

Year:  2021        PMID： 33385253     DOI： 10.1007/s00774-020-01191-1

Source DB:  PubMed          Journal:  J Bone Miner Metab        ISSN： 0914-8779            Impact factor:   2.626


  36 in total

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Authors:  Steven L Teitelbaum; F Patrick Ross
Journal:  Nat Rev Genet       Date:  2003-08       Impact factor: 53.242

Review 2.  Osteopetrosis.

Authors:  Jakub Tolar; Steven L Teitelbaum; Paul J Orchard
Journal:  N Engl J Med       Date:  2004-12-30       Impact factor: 91.245

3.  RANKL-Independent Osteoclastogenesis: A Long-Standing Controversy.

Authors:  Sakae Tanaka
Journal:  J Bone Miner Res       Date:  2017-02-17       Impact factor: 6.741

4.  Total absence of colony-stimulating factor 1 in the macrophage-deficient osteopetrotic (op/op) mouse.

Authors:  W Wiktor-Jedrzejczak; A Bartocci; A W Ferrante; A Ahmed-Ansari; K W Sell; J W Pollard; E R Stanley
Journal:  Proc Natl Acad Sci U S A       Date:  1990-06       Impact factor: 11.205

5.  LOX Fails to Substitute for RANKL in Osteoclastogenesis.

Authors:  Masayuki Tsukasaki; Koki Hamada; Kazuo Okamoto; Kazuki Nagashima; Asuka Terashima; Noriko Komatsu; Stephanie J Win; Tadashi Okamura; Takeshi Nitta; Hisataka Yasuda; Josef M Penninger; Hiroshi Takayanagi
Journal:  J Bone Miner Res       Date:  2016-10-03       Impact factor: 6.741

Review 6.  Osteoimmunology: The Conceptual Framework Unifying the Immune and Skeletal Systems.

Authors:  Kazuo Okamoto; Tomoki Nakashima; Masahiro Shinohara; Takako Negishi-Koga; Noriko Komatsu; Asuka Terashima; Shinichiro Sawa; Takeshi Nitta; Hiroshi Takayanagi
Journal:  Physiol Rev       Date:  2017-10-01       Impact factor: 37.312

7.  Interleukin-6 expression and histomorphometry of bones from mice deficient in receptors for interleukin-1 or tumor necrosis factor.

Authors:  S J Vargas; A Naprta; M Glaccum; S K Lee; J Kalinowski; J A Lorenzo
Journal:  J Bone Miner Res       Date:  1996-11       Impact factor: 6.741

Review 8.  The molecular understanding of osteoclast differentiation.

Authors:  Masataka Asagiri; Hiroshi Takayanagi
Journal:  Bone       Date:  2006-11-13       Impact factor: 4.398

9.  Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death.

Authors:  A B Kulkarni; C G Huh; D Becker; A Geiser; M Lyght; K C Flanders; A B Roberts; M B Sporn; J M Ward; S Karlsson
Journal:  Proc Natl Acad Sci U S A       Date:  1993-01-15       Impact factor: 11.205

Review 10.  Osteoimmunology: evolving concepts in bone-immune interactions in health and disease.

Authors:  Masayuki Tsukasaki; Hiroshi Takayanagi
Journal:  Nat Rev Immunol       Date:  2019-06-11       Impact factor: 53.106
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  11 in total

1.  Overexpression of Neurogenin 1 Negatively Regulates Osteoclast and Osteoblast Differentiation.

Authors:  Jung Ha Kim; Kabsun Kim; Inyoung Kim; Semun Seong; Jeong-Tae Koh; Nacksung Kim
Journal:  Int J Mol Sci       Date:  2022-06-16       Impact factor: 6.208

Review 2.  The Macrophage-Osteoclast Axis in Osteoimmunity and Osteo-Related Diseases.

Authors:  Yao Yao; Xiaoyu Cai; Fujia Ren; Yiqing Ye; Fengmei Wang; Caihong Zheng; Ying Qian; Meng Zhang
Journal:  Front Immunol       Date:  2021-03-31       Impact factor: 7.561

Review 3.  New Function of Cholesterol Oxidation Products Involved in Osteoporosis Pathogenesis.

Authors:  Yanting Che; Jingzhi Yang; Fen Tang; Ziheng Wei; Yufan Chao; Na Li; Henghui Li; Si Wu; Xin Dong
Journal:  Int J Mol Sci       Date:  2022-02-11       Impact factor: 5.923

4.  Urolithin B suppresses osteoclastogenesis via inhibiting RANKL-induced signalling pathways and attenuating ROS activities.

Authors:  Zechao Qu; Hao An; Mingzhe Feng; Wangli Huang; Dong Wang; Zhen Zhang; Liang Yan
Journal:  J Cell Mol Med       Date:  2022-07-03       Impact factor: 5.295

Review 5.  Osteoclast biology in the single-cell era.

Authors:  Masayuki Tsukasaki; Hiroshi Takayanagi
Journal:  Inflamm Regen       Date:  2022-09-02

Review 6.  Review of potential medical treatments for middle ear cholesteatoma.

Authors:  Matthias Schürmann; Peter Goon; Holger Sudhoff
Journal:  Cell Commun Signal       Date:  2022-09-19       Impact factor: 7.525

Review 7.  The monocyte-to-osteoclast transition in rheumatoid arthritis: Recent findings.

Authors:  Naoki Iwamoto; Atsushi Kawakami
Journal:  Front Immunol       Date:  2022-09-12       Impact factor: 8.786

8.  Sorting Nexin 10 as a Key Regulator of Membrane Trafficking in Bone-Resorbing Osteoclasts: Lessons Learned From Osteopetrosis.

Authors:  Ari Elson; Merle Stein; Grace Rabie; Maayan Barnea-Zohar; Sabina Winograd-Katz; Nina Reuven; Moran Shalev; Juraj Sekeres; Moien Kanaan; Jan Tuckermann; Benjamin Geiger
Journal:  Front Cell Dev Biol       Date:  2021-05-20

9.  Bone marrow derived stromal cells from myelodysplastic syndromes are altered but not clonally mutated in vivo.

Authors:  Johann-Christoph Jann; Maximilian Mossner; Vladimir Riabov; Eva Altrock; Nanni Schmitt; Johanna Flach; Qingyu Xu; Verena Nowak; Julia Obländer; Iris Palme; Nadine Weimer; Alexander Streuer; Ahmed Jawhar; Ali Darwich; Mohammad Jawhar; Georgia Metzgeroth; Florian Nolte; Wolf-Karsten Hofmann; Daniel Nowak
Journal:  Nat Commun       Date:  2021-10-25       Impact factor: 14.919

10.  The Neuropeptide VIP Limits Human Osteoclastogenesis: Clinical Associations with Bone Metabolism Markers in Patients with Early Arthritis.

Authors:  David Castro-Vazquez; Amalia Lamana; Paula Arribas-Castaño; Irene Gutiérrez-Cañas; Raúl Villanueva-Romero; Selene Pérez-García; Carmen Martínez; Yasmina Juarranz; Sara Fernández de Córdoba; Isidoro González-Álvaro; Rosa P Gomariz; Mar Carrión
Journal:  Biomedicines       Date:  2021-12-10
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