Literature DB >> 33385245

Genomic characteristics and pathogenicity of a new recombinant strain of porcine reproductive and respiratory syndrome virus.

Yang Li1, Gaoxiao Xu2, Xingqian Du1, Lele Xu1, Zhiqian Ma1, Zhiwei Li1, Yingtong Feng1, Dian Jiao1, Wenping Guo1, Shuqi Xiao3.   

Abstract

Recombination is an important phenomenon that accelerates evolution and enriches the genetic diversity of porcine reproductive and respiratory syndrome virus (PRRSV). Recombinant PRRSV isolates sometimes have different genetic backgrounds. In this study, we report a recombinant PRRSV (SD-YL1712) isolated from a pig farm. The genome of SD-YL1712 is 15,014 nucleotides in length, and its nucleotide and amino acid sequence conservation is higher than that of PRRSV strain JXA1 except within the NSP2 region. The NSP2 region of SDYL1712 shares the highest nucleotide (85.9%) and amino acid (84.1%) sequence identity with PRRSV strain NADC30. SD-YL1712 was found to contain a characteristic 131-amino-acid deletion in the NSP2 region. Two recombination breakpoints were detected at nt 2134 and nt 3958 within the NSP2 region, which revealed that SD-YL1712 originated from a recombination event between NADC30-like and HP-PRRSV-derived MLV-like strains. Interestingly, SD-YL1712 had an additional deletion at position 586, similar to that found in strain TJnh1501. Moreover, the pathogenicity of strain SD-YL1712 was found to be similar to that of HP-PRRSV JXA1, which was higher than that of the CH1a strain. Further analysis indicated that SD-YL1712 might be a transitional intermediate in the evolution of TJbd1401 to TJnh1501.

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Year:  2021        PMID： 33385245     DOI： 10.1007/s00705-020-04917-8

Source DB:  PubMed          Journal:  Arch Virol        ISSN： 0304-8608            Impact factor:   2.574


  46 in total

Review 1.  Porcine Reproductive and Respiratory Syndrome Virus (PRRSV): Pathogenesis and Interaction with the Immune System.

Authors:  Joan K Lunney; Ying Fang; Andrea Ladinig; Nanhua Chen; Yanhua Li; Bob Rowland; Gourapura J Renukaradhya
Journal:  Annu Rev Anim Biosci       Date:  2015-11-20       Impact factor: 8.923

2.  Characterization of swine infertility and respiratory syndrome (SIRS) virus (isolate ATCC VR-2332).

Authors:  D A Benfield; E Nelson; J E Collins; L Harris; S M Goyal; D Robison; W T Christianson; R B Morrison; D Gorcyca; D Chladek
Journal:  J Vet Diagn Invest       Date:  1992-04       Impact factor: 1.279

Review 3.  Control and elimination of porcine reproductive and respiratory syndrome virus.

Authors:  Cesar A Corzo; Enrique Mondaca; Spencer Wayne; Montserrat Torremorell; Scott Dee; Peter Davies; Robert B Morrison
Journal:  Virus Res       Date:  2010-09-17       Impact factor: 3.303

4.  Isolation of swine infertility and respiratory syndrome virus (isolate ATCC VR-2332) in North America and experimental reproduction of the disease in gnotobiotic pigs.

Authors:  J E Collins; D A Benfield; W T Christianson; L Harris; J C Hennings; D P Shaw; S M Goyal; S McCullough; R B Morrison; H S Joo
Journal:  J Vet Diagn Invest       Date:  1992-04       Impact factor: 1.279

5.  North American and European porcine reproductive and respiratory syndrome viruses differ in non-structural protein coding regions.

Authors:  R Allende; T L Lewis; Z Lu; D L Rock; G F Kutish; A Ali; A R Doster; F A Osorio
Journal:  J Gen Virol       Date:  1999-02       Impact factor: 3.891

6.  Identification of major differences in the nucleocapsid protein genes of a Québec strain and European strains of porcine reproductive and respiratory syndrome virus.

Authors:  H Mardassi; S Mounir; S Dea
Journal:  J Gen Virol       Date:  1994-03       Impact factor: 3.891

7.  Construction and immune protection evaluation of recombinant virus expressing Newcastle disease virus F protein by the largest intergenic region of fowlpox virus NX10.

Authors:  Yan Zhao; Zongxi Han; Xiaocai Zhang; Xuemei Zhang; Junfeng Sun; Deying Ma; Shengwang Liu
Journal:  Virus Genes       Date:  2020-10-03       Impact factor: 2.332

8.  Novel structural protein in porcine reproductive and respiratory syndrome virus encoded by an alternative ORF5 present in all arteriviruses.

Authors:  Craig R Johnson; Theodor F Griggs; Josephine Gnanandarajah; Michael P Murtaugh
Journal:  J Gen Virol       Date:  2011-02-09       Impact factor: 3.891

9.  Porcine reproductive and respiratory syndrome virus: an update on an emerging and re-emerging viral disease of swine.

Authors:  Joan K Lunney; David A Benfield; Raymond R R Rowland
Journal:  Virus Res       Date:  2010-10-14       Impact factor: 3.303

10.  Molecular characterization of porcine reproductive and respiratory syndrome virus, a member of the arterivirus group.

Authors:  K K Conzelmann; N Visser; P Van Woensel; H J Thiel
Journal:  Virology       Date:  1993-03       Impact factor: 3.616
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  2 in total

1.  The Novel PRRSV Strain HBap4-2018 with a Unique Recombinant Pattern Is Highly Pathogenic to Piglets.

Authors:  Pengfei Chen; Xiangmei Tan; Mengqin Lao; Xia Wu; Xiongwei Zhao; Shuting Zhou; Jiarong Yu; Junrui Zhu; Lingxue Yu; Wu Tong; Fei Gao; Hai Yu; Changlong Liu; Yifeng Jiang; Guangzhi Tong; Yanjun Zhou
Journal:  Virol Sin       Date:  2021-10-12       Impact factor: 6.947

2.  Lineage 1 Porcine Reproductive and Respiratory Syndrome Virus Attenuated Live Vaccine Provides Broad Cross-Protection against Homologous and Heterologous NADC30-Like Virus Challenge in Piglets.

Authors:  Hongliang Zhang; Lirun Xiang; Hu Xu; Chao Li; Yan-Dong Tang; Bangjun Gong; Wenli Zhang; Jing Zhao; Shuaijie Song; Jinmei Peng; Qian Wang; Tongqing An; Xuehui Cai; Zhi-Jun Tian
Journal:  Vaccines (Basel)       Date:  2022-05-10
  2 in total

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