Literature DB >> 33384320

What Is T+? A Gordian Knot of Tracers, Thresholds, and Topographies.

Victor L Villemagne1,2,3, Brian J Lopresti4, Vincent Doré5,6, Dana Tudorascu7, Milos D Ikonomovic7,8, Samantha Burnham6,9, Davneet Minhas4, Tharick A Pascoal7, N Scott Mason4, Beth Snitz7, Howard Aizenstein7, Chester A Mathis4, Oscar Lopez7, Christopher C Rowe2,5, William E Klunk7,8, Ann D Cohen7.   

Abstract

In this review we examine, in the context of the amyloid, tau, and neurodegeneration framework, the available evidence and potential alternatives on how to establish tau positivity (T+) for multiple tau-imaging tracers in order to reach a consensus on normal and abnormal tau imaging values that can be universally implemented in clinical research and therapeutic trials.
© 2021 by the Society of Nuclear Medicine and Molecular Imaging.

Entities:  

Keywords:  AT(N) framework; Alzheimer disease; biomarkers; brain imaging; tau imaging

Year:  2020        PMID： 33384320     DOI： 10.2967/jnumed.120.245423

Source DB:  PubMed          Journal:  J Nucl Med        ISSN： 0161-5505            Impact factor:   10.057


  5 in total

1.  Spatial decrease of synaptic density in amnestic mild cognitive impairment follows the tau build-up pattern.

Authors:  Greet Vanderlinden; Jenny Ceccarini; Thomas Vande Casteele; Laura Michiels; Robin Lemmens; Eric Triau; Kim Serdons; Jos Tournoy; Michel Koole; Mathieu Vandenbulcke; Koen Van Laere
Journal:  Mol Psychiatry       Date:  2022-07-06       Impact factor: 15.992

2.  Bundle-specific associations between white matter microstructure and Aβ and tau pathology in preclinical Alzheimer's disease.

Authors:  Alexa Pichet Binette; Guillaume Theaud; François Rheault; Maggie Roy; D Louis Collins; Johannes Levin; Hiroshi Mori; Jae Hong Lee; Martin Rhys Farlow; Peter Schofield; Jasmeer P Chhatwal; Colin L Masters; Tammie Benzinger; John Morris; Randall Bateman; John Cs Breitner; Judes Poirier; Julie Gonneaud; Maxime Descoteaux; Sylvia Villeneuve
Journal:  Elife       Date:  2021-05-13       Impact factor: 8.140

3.  Impact of meningeal uptake and partial volume correction techniques on [18F]MK-6240 binding in aMCI patients and healthy controls.

Authors:  Nathalie Mertens; Laura Michiels; Greet Vanderlinden; Mathieu Vandenbulcke; Robin Lemmens; Koen Van Laere; Michel Koole
Journal:  J Cereb Blood Flow Metab       Date:  2022-01-21       Impact factor: 6.960

4.  Deep learning improves utility of tau PET in the study of Alzheimer's disease.

Authors:  James Zou; David Park; Aubrey Johnson; Xinyang Feng; Michelle Pardo; Jeanelle France; Zeljko Tomljanovic; Adam M Brickman; Devangere P Devanand; José A Luchsinger; William C Kreisl; Frank A Provenzano
Journal:  Alzheimers Dement (Amst)       Date:  2021-12-31

5.  Longitudinally Increasing Elevated Asymmetric Flortaucipir Binding in a Cognitively Unimpaired Amyloid-Negative Older Individual.

Authors:  Christopher G Schwarz; David S Knopman; Vijay K Ramanan; Val J Lowe; Heather J Wiste; Petrice M Cogswell; Rene L Utianski; Matthew L Senjem; Jeffrey R Gunter; Prashanthi Vemuri; Ronald C Petersen; Clifford R Jack
Journal:  J Alzheimers Dis       Date:  2022       Impact factor: 4.472
  5 in total

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