A Z Soh1, C T Y Tan2, E Mok3, C B E Chee4, J-M Yuan5, A Larbi2, W-P Koh6. 1. Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore. 2. Singapore Immunology Network, Agency for Science, Technology and Research (ASTAR), Singapore. 3. Immunomonitoring Platform, Singapore Immunology Network, ASTAR, Singapore. 4. Singapore Tuberculosis Control Unit, Tan Tock Seng Hospital, Singapore. 5. Division of Cancer Control and Population Sciences, University of Pittsburgh Medical Center Hillman Cancer Center, Pittsburgh, PA, USA, Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA, USA. 6. Health Services and Systems Research, Duke-National University of Singapore Medical School Singapore, Singapore, Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore.
Abstract
BACKGROUND: Adipokines are emerging mediators of immune response, and may affect susceptibility to active TB. OBJECTIVE: To examine the associations between adipokines and the risk of active TB. METHODS: In a case-control study nested within a prospective cohort of middle-aged and older adults in Singapore, 280 incident active TB cases who donated blood for research before diagnosis were matched with 280 controls. Serum levels of adiponectin, resistin, leptin and ghrelin were measured. Multivariable logistic regression models were used to compute the adjusted odds ratios (ORs) and 95% confidence intervals (CIs) for the associations between adipokines and the risk of active TB. RESULTS: Higher levels of leptin and resistin were associated with reduced risk of TB in a dose-dependent manner. Compared to those in the lowest quartile of leptin levels, those in the highest quartile had an OR of 0.46 (95%CI 0.26-0.82; P for trend = 0.009). Similarly, compared to those in the lowest quartile of resistin levels, those in the highest quartile had an OR of 0.46 (95%CI 0.24-0.90; P for trend = 0.03). Adiponectin and ghrelin levels were not associated with TB risk. CONCLUSION: Increased serum levels of leptin and resistin may be associated with reduced susceptibility to active TB infection.
BACKGROUND: Adipokines are emerging mediators of immune response, and may affect susceptibility to active TB. OBJECTIVE: To examine the associations between adipokines and the risk of active TB. METHODS: In a case-control study nested within a prospective cohort of middle-aged and older adults in Singapore, 280 incident active TB cases who donated blood for research before diagnosis were matched with 280 controls. Serum levels of adiponectin, resistin, leptin and ghrelin were measured. Multivariable logistic regression models were used to compute the adjusted odds ratios (ORs) and 95% confidence intervals (CIs) for the associations between adipokines and the risk of active TB. RESULTS: Higher levels of leptin and resistin were associated with reduced risk of TB in a dose-dependent manner. Compared to those in the lowest quartile of leptin levels, those in the highest quartile had an OR of 0.46 (95%CI 0.26-0.82; P for trend = 0.009). Similarly, compared to those in the lowest quartile of resistin levels, those in the highest quartile had an OR of 0.46 (95%CI 0.24-0.90; P for trend = 0.03). Adiponectin and ghrelin levels were not associated with TB risk. CONCLUSION: Increased serum levels of leptin and resistin may be associated with reduced susceptibility to active TB infection.