| Literature DB >> 33382271 |
Song Sun1, Zhaobin Wang2, Shijia Li2,3, Cong Zhou1, Lijuan Song3, Hai Huang1, Jianwei Sun1,2.
Abstract
We report the first organocatalytic kinetic resolution of unactivated aziridines by sulfur nucleophiles with excellent enantioselectivity. A suitable chiral phosphoric acid was found to catalyze the intermolecular ring opening under mild conditions, furnishing a range of highly enantioenriched β-amino thioethers and aziridines, both of which are useful synthetic building blocks.Entities:
Year: 2020 PMID： 33382271 DOI： 10.1021/acs.orglett.0c04074
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005