Metabolic and Endocrine Changes Determined in Saliva of Adolescents Engaged in Computer Gaming.

Passion for computer games negatively affects the health level of schoolchildren. Among the approaches to monitoring the functional state of such schoolchildren, the most informative and painless is the study of the saliva. The study involved 45 children, aged 14.00 ± 0.21 years, and divided according to the contact's intensity with computer games. The following indicators of lipid peroxidation (LPO) were determined in the saliva: indicators of the antioxidant (AO) system, concentration of immunoglobulin A, and hormonal indicators. The significant increases in the catecholamine (adrenaline) level for 2.3 times and biogenic amine-serotonin for 35.5% and increase in the LPO-DC product concentration in gamers for 75.8% were revealed. The study of the schoolchildren's homeostasis peculiarities confirmed the adequacy of the use of biochemical techniques to assess the condition of children gamers. They have a prenosological condition. This is reflected in the increase in LPO intensity, failure of the protective AO system, imbalance of hormonal state, and immunity deterioration. Information on the evaluation of the LPO activity processes and the AO system condition and the degree of the balance's shift between prooxidants and antioxidants in biological substrates can be considered objective and very sensitive indicators of the general condition, activity, and improvement of the regulation and maintenance of homeostasis.