Yanfeng Ren1, Maohua Miao2, Wei Yuan2, Jiangwei Sun3. 1. Department of Health Statistics, School of Public Health, Weifang Medical University, Shandong, China. 2. NHC Key Lab. of Reproduction Regulation, Shanghai Institute of Planned Parenthood Research), Fudan University, Shanghai, China. 3. Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden. jiangwei.sun@ki.se.
Abstract
BACKGROUND: Although a U-shaped association between sleep duration and all-cause mortality has been found in general population, its association in the elderly adults, especially in the oldest-old, is rarely explored. METHODS: In present cohort study, we prospectively explore the association between sleep duration and all-cause mortality among 15,092 participants enrolled in the Chinese Longitudinal Healthy Longevity Survey (CLHLS) from 2005 to 2019. Sleep duration and death information was collected by using structured questionnaires. Cox regression model with sleep duration as a time-varying exposure was performed to calculate the hazard ratios (HRs) and 95% confidence intervals (CIs). The dose-response association between them was explored via a restricted cubic spline function. RESULTS: During an average follow-up of 4.51 (standard deviation, SD: 3.62) years, 10,768 participants died during the follow-up period. The mean (SD) age of the participants was 89.26 (11.56) years old. Compared to individuals with moderate sleep duration (7-8 hours), individuals with long sleep duration (> 8 hours) had a significantly higher risk of all-cause mortality (HR: 1.13, 95%CI: 1.09-1.18), but not among individuals with short sleep duration (≤ 6 hours) (HR: 1.02, 95%CI: 0.96-1.09). Similar results were observed in subgroup analyses based on age and gender. In the dose-response analysis, a J-shaped association was observed. CONCLUSIONS: Sleep duration was associated with all-cause mortality in a J-shaped pattern in the elderly population in China.
BACKGROUND: Although a U-shaped association between sleep duration and all-cause mortality has been found in general population, its association in the elderly adults, especially in the oldest-old, is rarely explored. METHODS: In present cohort study, we prospectively explore the association between sleep duration and all-cause mortality among 15,092 participants enrolled in the Chinese Longitudinal Healthy Longevity Survey (CLHLS) from 2005 to 2019. Sleep duration and death information was collected by using structured questionnaires. Cox regression model with sleep duration as a time-varying exposure was performed to calculate the hazard ratios (HRs) and 95% confidence intervals (CIs). The dose-response association between them was explored via a restricted cubic spline function. RESULTS: During an average follow-up of 4.51 (standard deviation, SD: 3.62) years, 10,768 participants died during the follow-up period. The mean (SD) age of the participants was 89.26 (11.56) years old. Compared to individuals with moderate sleep duration (7-8 hours), individuals with long sleep duration (> 8 hours) had a significantly higher risk of all-cause mortality (HR: 1.13, 95%CI: 1.09-1.18), but not among individuals with short sleep duration (≤ 6 hours) (HR: 1.02, 95%CI: 0.96-1.09). Similar results were observed in subgroup analyses based on age and gender. In the dose-response analysis, a J-shaped association was observed. CONCLUSIONS: Sleep duration was associated with all-cause mortality in a J-shaped pattern in the elderly population in China.
Authors: James E Gangwisch; Steven B Heymsfield; Bernadette Boden-Albala; Ruud M Buijs; Felix Kreier; Mark G Opler; Thomas G Pickering; Andrew G Rundle; Gary K Zammit; Dolores Malaspina Journal: Sleep Date: 2008-08 Impact factor: 5.849
Authors: Vlad Sever Neculicioiu; Ioana Alina Colosi; Carmen Costache; Alexandra Sevastre-Berghian; Simona Clichici Journal: Int J Environ Res Public Health Date: 2022-03-16 Impact factor: 4.614