Chung-Min Yeh1,2, Yi-Ju Lee3,4,5, Po-Yun Ko5,6, Yueh-Min Lin1,5, Wen-Wei Sung5,7,8. 1. Department of Pathology, Changhua Christian Hospital, Changhua 50006, Taiwan. 2. Department of Medical Technology, Jen-Teh Junior College of Medicine, Nursing and Management, Miaoli 35664, Taiwan. 3. Department of Pathology, Chung Shan Medical University, Taichung 40201, Taiwan. 4. Department of Pathology, Chung Shan Medical University Hospital, Taichung 40201, Taiwan. 5. School of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan. 6. Department of Medical Education, MacKay Memorial Hospital, Taipei 10491, Taiwan. 7. Institute of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan. 8. Department of Urology, Chung Shan Medical University Hospital, Taichung 40201, Taiwan.
Abstract
BACKGROUND AND OBJECTIVES: Krüppel-like transcription factor 10 (KLF10) plays a vital role in regulating cell proliferation, including the anti-proliferative process, activation of apoptosis, and differentiation control. KLF10 may also act as a protective factor against oral cancer. We studied the impact of KLF10 expression on the clinical outcomes of oral cancer patients to identify its role as a prognostic factor in oral cancer. MATERIALS AND METHODS: KLF10 immunoreactivity was analyzed by immunohistochemical (IHC) stain analysis in 286 cancer specimens from primary oral cancer patients. The prognostic value of KLF10 on overall survival was determined by Kaplan-Meier analysis and the Cox proportional hazard model. RESULTS: High KLF10 expression was significantly associated with male gender and betel quid chewing. The 5-year survival rate was greater for patients with high KLF10 expression than for those with low KLF10 expression (62.5% vs. 51.3%, respectively; p = 0.005), and multivariate analyses showed that high KLF10 expression was the only independent factor correlated with greater overall patient survival. The significant correlation between high KLF10 expression and a higher 5-year survival rate was observed in certain subgroups of clinical parameters, including female gender, non-smokers, cancer stage T1, and cancer stage N0. CONCLUSIONS: KLF10 expression, detected by IHC staining, could be an independent prognostic marker for oral cancer patients.
BACKGROUND AND OBJECTIVES: Krüppel-like transcription factor 10 (KLF10) plays a vital role in regulating cell proliferation, including the anti-proliferative process, activation of apoptosis, and differentiation control. KLF10 may also act as a protective factor against oral cancer. We studied the impact of KLF10 expression on the clinical outcomes of oral cancer patients to identify its role as a prognostic factor in oral cancer. MATERIALS AND METHODS: KLF10 immunoreactivity was analyzed by immunohistochemical (IHC) stain analysis in 286 cancer specimens from primary oral cancer patients. The prognostic value of KLF10 on overall survival was determined by Kaplan-Meier analysis and the Cox proportional hazard model. RESULTS: High KLF10 expression was significantly associated with male gender and betel quid chewing. The 5-year survival rate was greater for patients with high KLF10 expression than for those with low KLF10 expression (62.5% vs. 51.3%, respectively; p = 0.005), and multivariate analyses showed that high KLF10 expression was the only independent factor correlated with greater overall patient survival. The significant correlation between high KLF10 expression and a higher 5-year survival rate was observed in certain subgroups of clinical parameters, including female gender, non-smokers, cancer stage T1, and cancer stage N0. CONCLUSIONS: KLF10 expression, detected by IHC staining, could be an independent prognostic marker for oral cancer patients.
Authors: C-C Weng; J R Hawse; M Subramaniam; V H S Chang; W C Y Yu; W-C Hung; L-T Chen; K-H Cheng Journal: Oncogene Date: 2017-06-05 Impact factor: 9.867
Authors: Konstantinos A Papadakis; James Krempski; Jesse Reiter; Phyllis Svingen; Yuning Xiong; Olga F Sarmento; April Huseby; Aaron J Johnson; Gwen A Lomberk; Raul A Urrutia; William A Faubion Journal: Am J Physiol Cell Physiol Date: 2014-12-03 Impact factor: 4.249
Authors: M Subramaniam; S A Harris; M J Oursler; K Rasmussen; B L Riggs; T C Spelsberg Journal: Nucleic Acids Res Date: 1995-12-11 Impact factor: 16.971
Authors: Nadine Baroukh; Nathan Canteleux; Antoine Lefèvre; Camille Dupuy; Cécile Martias; Antoine Presset; Malayannan Subramaniam; John R Hawse; Patrick Emond; Philippe Pouletaut; Sandrine Morandat; Sabine F Bensamoun; Lydie Nadal-Desbarats Journal: Metabolites Date: 2022-06-17