BACKGROUND: Since the outbreak of the COVID-19 pandemic, a number of risk factors for a poor outcome have been identified. Thereby, cardiovascular comorbidity has a major impact on mortality. We investigated whether coronary calcification as a marker for coronary artery disease (CAD) is appropriate for risk prediction in COVID-19. METHODS: Hospitalized patients with COVID-19 (n = 109) were analyzed regarding clinical outcome after native computed tomography (CT) imaging for COVID-19 screening. CAC (coronary calcium score) and clinical outcome (need for intensive care treatment or death) data were calculated following a standardized protocol. We defined three endpoints: critical COVID-19 and transfer to ICU, fatal COVID-19 and death, composite endpoint critical and fatal COVID-19, a composite of ICU treatment and death. We evaluated the association of clinical outcome with the CAC. Patients were dichotomized by the median of CAC. Hazard ratios and odds ratios were calculated for the events death or ICU or a composite of death and ICU. RESULTS: We observed significantly more events for patients with CAC above the group's median of 31 for critical outcome (HR: 1.97[1.09,3.57], p = 0.026), for fatal outcome (HR: 4.95[1.07,22.9], p = 0.041) and the composite endpoint (HR: 2.31[1.28,4.17], p = 0.0056. Also, odds ratio was significantly increased for critical outcome (OR: 3.01 [1.37, 6.61], p = 0.01) and for fatal outcome (OR: 5.3 [1.09, 25.8], p = 0.02). CONCLUSION: The results indicate a significant association between CAC and clinical outcome in COVID-19. Our data therefore suggest that CAC might be useful in risk prediction in patients with COVID-19.
BACKGROUND: Since the outbreak of the COVID-19 pandemic, a number of risk factors for a poor outcome have been identified. Thereby, cardiovascular comorbidity has a major impact on mortality. We investigated whether coronary calcification as a marker for coronary artery disease (CAD) is appropriate for risk prediction in COVID-19. METHODS: Hospitalized patients with COVID-19 (n = 109) were analyzed regarding clinical outcome after native computed tomography (CT) imaging for COVID-19 screening. CAC (coronary calcium score) and clinical outcome (need for intensive care treatment or death) data were calculated following a standardized protocol. We defined three endpoints: critical COVID-19 and transfer to ICU, fatal COVID-19 and death, composite endpoint critical and fatal COVID-19, a composite of ICU treatment and death. We evaluated the association of clinical outcome with the CAC. Patients were dichotomized by the median of CAC. Hazard ratios and odds ratios were calculated for the events death or ICU or a composite of death and ICU. RESULTS: We observed significantly more events for patients with CAC above the group's median of 31 for critical outcome (HR: 1.97[1.09,3.57], p = 0.026), for fatal outcome (HR: 4.95[1.07,22.9], p = 0.041) and the composite endpoint (HR: 2.31[1.28,4.17], p = 0.0056. Also, odds ratio was significantly increased for critical outcome (OR: 3.01 [1.37, 6.61], p = 0.01) and for fatal outcome (OR: 5.3 [1.09, 25.8], p = 0.02). CONCLUSION: The results indicate a significant association between CAC and clinical outcome in COVID-19. Our data therefore suggest that CAC might be useful in risk prediction in patients with COVID-19.
Authors: R Y Possari; H J Andrade-Gomes; V C Mello; E A Galdeano; L F Aguiar-Filho; M S Bittencourt; E V Ponte; L R Bertoche; L R S Caio; J D Rodrigues; F B Alcantara; M A C Freitas; J C G C Sarinho; N K Cervigne; W M Rodrigues; I Aprahamian Journal: Braz J Med Biol Res Date: 2021-12-03 Impact factor: 2.590
Authors: A Cereda; L Allievi; A Palmisano; G Tumminello; L Barbieri; A Mangieri; A Laricchia; A Khokhar; F Giannini; M Toselli; G M Sangiorgi; A Esposito; P Aseni; S Lucreziotti; A Mafrici; S Carugo Journal: Emerg Radiol Date: 2022-04-30
Authors: Bibi Martens; Rob G H Driessen; Lloyd Brandts; Puck Hoitinga; Fauve van Veen; Mariëlle Driessen; Vanessa Weberndörfer; Bas Kietselaer; Chahinda Ghossein-Doha; Hester A Gietema; Kevin Vernooy; Iwan C C van der Horst; Joachim E Wildberger; Bas C T van Bussel; Casper Mihl Journal: J Thorac Imaging Date: 2022-04-13 Impact factor: 5.528
Authors: Carlo Tacchetti; Antonio Esposito; Anna Palmisano; Davide Vignale; Edda Boccia; Alessandro Nonis; Chiara Gnasso; Riccardo Leone; Marco Montagna; Valeria Nicoletti; Antonello Giuseppe Bianchi; Stefano Brusamolino; Andrea Dorizza; Marco Moraschini; Rahul Veettil; Alberto Cereda; Marco Toselli; Francesco Giannini; Marco Loffi; Gianluigi Patelli; Alberto Monello; Gianmarco Iannopollo; Davide Ippolito; Elisabetta Maria Mancini; Gianluca Pontone; Luigi Vignali; Elisa Scarnecchia; Mario Iannacone; Lucio Baffoni; Massimiliano Sperandio; Caterina Chiara de Carlini; Sandro Sironi; Claudio Rapezzi; Luca Antiga; Veronica Jagher; Clelia Di Serio; Cesare Furlanello Journal: Radiol Med Date: 2022-08-29 Impact factor: 6.313
Authors: Maria-Luiza Luchian; Stijn Lochy; Andreea Motoc; Dries Belsack; Julien Magne; Bram Roosens; Johan de Mey; Kaoru Tanaka; Esther Scheirlynck; Sven Boeckstaens; Karen Van den Bussche; Tom De Potter; Berlinde von Kemp; Xavier Galloo; Clara François; Caroline Weytjens; Steven Droogmans; Bernard Cosyns Journal: Front Cardiovasc Med Date: 2021-07-09