| Literature DB >> 33377539 |
Raoul Sutter1,2,3,4, Lisa Hert1,2, Gian Marco De Marchis2,3,4, Raphael Twerenbold3,4,5,6, Ludwig Kappos2,3,4,7, Yvonne Naegelin2,3, Gabriela M Kuster5,7, Pascal Benkert4,8, Jasmine Jost9, Aleksandra Maleska Maceski2,3,4,7, Stephan Rüegg2,3, Martin Siegemund1,3,4, David Leppert2,3,4,7, Sarah Tschudin-Sutter3,4,10, Jens Kuhle2,3,4,7.
Abstract
There is emerging evidence for multifarious neurological manifestations of coronavirus disease 2019 (COVID-19), but little is known regarding whether they reflect structural damage to the nervous system. Serum neurofilament light chain (sNfL) is a specific biomarker of neuronal injury. We measured sNfL concentrations of 29 critically ill COVID-19 patients, 10 critically ill non-COVID-19 patients, and 259 healthy controls. After adjusting for neurological comorbidities and age, sNfL concentrations were higher in patients with COVID-19 versus both comparator groups. Higher sNfL levels were associated with unfavorable short-term outcome, indicating that neuronal injury is common and pronounced in critically ill patients. ANN NEUROL 2021;89:610-616.Entities:
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Year: 2021 PMID： 33377539 DOI： 10.1002/ana.26004
Source DB: PubMed Journal: Ann Neurol ISSN： 0364-5134 Impact factor: 10.422