Quality of Life and Associated Factors Among Patients with Epilepsy Attending Outpatient Department of Saint Amanuel Mental Specialized Hospital, Addis Ababa, Ethiopia, 2019.

BACKGROUND: Epilepsy is strongly associated with an impaired quality of life. Patients suffering from epilepsy have a poorer quality of life than both the general population and many other chronic disease sufferers. However, attention is not given on the quality of life of people with epilepsy other than focusing on symptom reduction. This increases the frequency of seizures, impacts on the ability to perform and increases health-related costs. The aim of this study was to assess quality of life and associated factors among patients with epilepsy attending the outpatient department of Amanuel Mental Specialized Hospital, Addis Ababa, Ethiopia.
METHODS: An institution-based cross-sectional study design was conducted between May and June 2019 at Amanuel Mental Specialized Hospital. A systematic random sampling technique was used to get a total number of 447 samples. Data on quality of life was assessed through interviews using the World Health Organization Quality of Life-Brief (WHOQOL-BREF) Version. The collected data were coded, entered into EpiData 3.1, and analyzed by using SPSS version 20. Simple and multiple linear regression analysis models were fitted and the unstandardized β coefficient at 95% confidence interval was employed. The statistical significance was accepted at p-value <0.05.
RESULTS: The mean score of quality of life was 61.1±11.6 (95%CI: 59.05, 61.23). Perceived stigma (β=-2.13, 95%CI:-2.96, -1.30), frequent seizure (β=-3.16, 95%CI: -4.27, -2.04), AED adherence (β=1.24, 95%CI: 1.10, 1.30), antiepileptic drug side effect (β=-0.32, 95%CI: -0.38, -0.26), anxiety (β-1.91, 95%CI: -2.95, -0.86), depression (β=-3.59, 95%CI: -4.67, -2.52), poor social support (β=-2.51, 95%CI: -3.62, -1.40) and moderate social support (β=-1.60, 95%CI: -2.58, -0.62) were significantly associated factors with quality of life.
CONCLUSION: The finding from this study indicated that quality of life of patients with epilepsy were moderate. Perceived stigma, frequent seizure, comorbid depression and anxiety, antiepileptic drug nonadherence, antiepileptic drug side effect and poor social support were the predictors of quality of life.

Introduction

Epilepsy is a common neurological disorder characterized by recurrent episodes of unprovoked seizures with or without loss of consciousness.1 It affects approximately 69 million people worldwide. The majority, 90% lives in resource-poor countries.2 It has a wide global distribution with high prevalence in the developing world such as in sub-Saharan African countries.3 In Ethiopia, epilepsy is a public health problem, with an estimated prevalence of the disease in the country reported to be 5.2/1000 inhabitants at risk with the annual incidence of 64 in100,000 inhabitants in large scale, rural and community based studies.4,5

Epilepsy can be associated with a considerable physical and emotional impact on a person’s quality of life. The impact can be greater than that of many other chronic diseases. These impacts lead to limitation in employment, independence and social activities.6 People with epilepsy may fear to go outside their homes unaccompanied. They may fear what other people may think of them if they have a seizure in public. All over the world throughout history, epilepsy has been a culturally devalued condition. This devaluing often leads to stigma and psychosocial burden. In most parts of the world, epilepsy is believed to be contagious and possession by the devil and ancestral spirits.7 They experience different psychosocial challenges at different level of health system. It has an enormous impact on quality of life and lowering income compared with other people with chronic illness.8,9

Quality of life is defined by the World Health Organization (WHO) as individuals’ perceptions of their position in life in the context of the culture and value systems in which they live and in relation to their goals, expectations, standards, and concerns.10 It is a broad concept incorporating in a complex way subjective assessment of his or her physical health, psychological state, level of independence, social relationships, personal beliefs and their relationships to their environment.11 The scope of quality of life extends beyond traditional symptom reduction and includes the patient’s subjective feeling of well-being, satisfaction, functioning and impairment.12 Epilepsy affects many aspects of quality of life, including social functioning, the ability to concentrate on things, the ability to work with full potential, psychological aspect, and other daily activity.1 In some situations, perceived stigma and its impact on quality of life may pose a bigger challenge than the clinical severity. The incorporation of quality-of-life measurements into the assessment of treatment outcomes is a critical concept in health care today, and reflects a shift away from sole reliance on physical signs and diagnostic studies.13

Quality of life among people with epilepsy is significantly affected by several clinical and demographic factors such as being female, younger age, being single and divorced, education status and unemployment, early age of onset, seizure frequency, perceive stigma, lack of social support, comorbidity, AED nonadherence, antiepileptic drug side effect, and substance abuse have been shown as the major contributing factors on QOL of people with epilepsy.9,14–17

Evaluation of the impact of epilepsy on quality of life would throw light on various factors that affect quality of life in such a population. There is a growing consensus that successful treatment should not only target symptom severity, but also impairment in functioning and QOL in leading to restoration of health.18,19 However, guidelines have a considerable focus only on pharmacotherapy for symptomatic recovery20 and the majority of clinical and research efforts in this area have been more attentive to the impact of interventions on symptom reduction than on well-being or QOL.21 In developing countries, there is a scarcity of established evidence for quantifying the impact of epilepsy on quality of life. The issue of assessing quality of life and the factors contributing is highly overlooked among patient with epilepsy in Ethiopia. Therefore, the aim of this study was to assess quality of life and associated factors among patients with epilepsy, and the results of this study will add an input to policy makers to scale up a public health program for designing and implementing strategies to improve quality of life.

Objective

This aim of this study is to assess quality of life and associated factors among patients with epilepsy attending outpatient department of Saint Amanuel Mental Specialized Hospital, Addis Ababa, Ethiopia.

Study Setting and Population

An institution-based cross-sectional study was conducted among patients with epilepsy at Saint Amanuel Mental Specialized Hospital, Addis Ababa, Ethiopia, in May and June 2019. Addis Ababa, the capital of Ethiopia, had a total of 608 health facilities (hospitals, health centers, and private clinics) serving more than three million inhabitants. Saint Amanuel Mental Specialized Hospital (AMSH) is the only specialized mental hospital in the city. It is administered under the Federal Ministry of Health and provides mental health service for patients coming from the entire nation. The hospital has a total of 300 beds and 18 outpatient departments that serve patients with psychiatric disorders, of these three OPDs serve patients with epilepsy. In 2019, around 14,388 patients with epilepsy visited the outpatients department for follow-up in the six months from September to February. On average 2398 patients with epilepsy visited the hospital, in one month.

Participants

The participants of this study were epileptic patients receiving follow-up care at AMSH, Addis Ababa, Ethiopia. The single population mean formula with the assumptions of 56.36±13.37 mean and standard deviation of the overall quality of life of a study conducted in Ethiopia,14 1.96 Z (standard normal distribution), 95%CI, α=0.05, and a 10% nonresponse rate. The calculated sample size yielded 447. The average number of patients was calculated with their monthly visit in mind. Participants were selected for interviews using the systematic random sampling technique.

Inclusion and Exclusion Criteria

All patients with epilepsy who had six months and above follow-ups at the neurologic clinic and who were ≥18 years of age were included, whereas participants with intellectual disability were excluded.

Measurement

Quality of life was measured using World Health Organization Quality of Life—Brief (WHOQOL-BREF). The WHOQOL-BREF was developed by the WHOQOL group with 4500 respondents in 15 international field centers, which is a cross-culturally validated tool and used to assess the patients’ quality of life. The WHOQOL-BREF includes 26 items measuring the following domains: physical health, psychological health, social relationships, and environment. Two further items evaluate the individual’s overall perception of quality of life and the individual’s overall perception of their health. Domain scores are scaled in a positive direction (ie, higher scores correspond to better quality of life). QOL raw scores are transformed into a range of 0–100. The overall quality of life was computed as the average of the score of the four domains. The higher mean score indicates better the quality of life and vice versa.

Social support was measured by the Oslo Social Support Scale. The scale ranged from 3–14, and the scores 3–8, 9–11, and 12–14 stood for “poor”, “moderate”, and “strong” social support, respectively.22

Anxiety and depression symptoms were measured using the Hospital Anxiety and Depression Scale (HADS). It has 14 items and two subscales. Anxiety subscale (HADS-A) and depression subscale (HADS-D). There are seven items measuring cognitive and emotional aspects of depressive symptoms, and the other seven items were focusing on cognitive and emotional aspects of anxiety. HADS was a reliable and valid instrument in Ethiopia.23 Patients who scored ≥8 for both anxiety and depression symptoms were considered as having depression and anxiety.

Perceived stigma was measured by using a three-item Jacoby perceived stigma scale, which was developed originally for another neurological condition, stroke, for which it was shown to have good psychometric properties and was subsequently adapted for epilepsy. Each of the three items requires a simple yes/no response.24

AED adherence was measured by the Medication Adherence Reporting Scale-5 (MARS-5). The MARS-5, a self-reported instrument containing five items regarding medication adherence. Each item was rated on a five-point Likert scale and the range of the MARS-5 total score was between 5 and 25. A higher score on the MARS-5 represents a better medication adherence.25

The Liverpool Adverse Events Profile (LAEP) was used to assess AED side effects. It was developed in the 1990s by the Liverpool group and the LAEP was used to assess the frequency of AED side effects during the last four weeks. It has 19 items rated on a four-point Likert scale with (1) “never a problem” to (4) “always a problem” and the total scores range from 19 to 76, with the higher score indicating more frequent symptoms reporting.26 Substance-related factors were assessed by ASSIST which is a brief screening questionnaire developed by WHO. This tool was used to assess the current psychoactive substance use of the participants.27

Items on sociodemographic factors (age, sex, ethnicity, religion, marital status, educational status, and occupational status) were adopted from a variety of literature.

Data Collection Technique

To assure the quality of data high emphasis was given to designing the data collection instrument for its simplicity. The pretest was done on 5% (23) of the samples, on patients with epilepsy five days prior to the data collection at St Paul’s Millennium Medical College Hospital. The questionnaire was checked for clarity, simplicity, and understandability. The reliability test was done on the scale to assess the quality of life and the Cronbach’s alpha was 0.85. Data collectors were trained on an introduction to epilepsy, quality of life, research methods, interviewing skills, sampling, recruitment, and the ethical aspects of the research.

Furthermore, they were made aware of ethical principles, such as confidentiality/anonymity/and securing respondents’ informed consent for participation. Data were collected by three BSc psychiatry nurses and regularly supervised by one senior master psychiatry professor. The collected data were reviewed and check for completeness and relevance by the principal investigator each day.

Data Processing and Analysis

The collected data were coded, entered in to EpiData version 3.1 and analyzed by using SPSS version 20. Descriptive statistics (frequency, percent, mean and standard deviation) were used to summarize data and evaluate the distribution of responses. Assumption tests were checked. In simple linear regression, variables with p-value <0.20 were entered into multiple linear regression to overcome confounding variables. The multiple coefficient of determination (R2) was used for the model fitness. The result was expressed as unstandardized ß coefficient with 95% confidence level and p-value <0.05 was considered statistically significant.

Ethical Approval and Consent to Participate

Ethical approval and clearance were obtained from the Joint Ethical Review Committee of the University of Gondar and AMSH. A formal letter of permission was obtained from AMSH. Written informed consent was obtained from each study participants after explaining the purpose and benefit of the study. This study was conducted in accordance with the Declaration of Helsinki. The participants were informed that they have the right to refuse participation in the study at any time and refusing to participate will not affect them. The study subjects were assured confidentiality as the information they give will not be used for any purpose other than for the study.

Results

A total of 439 participants took part with a response rate of 98.2%. The mean age of the participants was 34 (±SD=10) years; more than half (64.7%), of were male; 231 (52.6%) were not married; 129 (29.4%) had secondary school education; 273 (62.2%) were Orthodox Christian, and 146 (33.3%) were Amhara by ethnicity. Regarding occupation, 182 (41.5%) of the participants were unemployed (Table 1).

Table 1

Sociodemographic Characteristics of Patients with Epilepsy on Follow-up at Amanuel Mental Specialized Hospital, Addis Ababa, Ethiopia, 2019 (N=439)

Variables	Categories	Frequency	Percentage
Age (mean ±SD)	34.62±10.37
Sex	Male	284	64.7
	Female	155	35.3
Religion	Orthodox	273	62.2
	Muslim	101	23
	Protestant	53	12.1
	Othersa	12	2.7
Ethnicity	Amhara	146	33.3
	Oromo	134	30.5
	Tigre	20	4.6
	Gurage	116	26.4
	Othersb	23	5.2
Marital status	Single	231	52.6
	Married	163	37.1
	Divorced/widowed	45	10.3
Educational status	No formal education	94	21.4
	Primary	126	28.7
	Secondary	129	29.4
	Tertiary and above	90	20.5
Occupational status	Employed	114	25.9
	Private business	122	27.8
	Unemployed	182	41.5
	Othersc	21	4.8

Notes: aCatholic, Wakefeta, Hawariyat. bHadia, Wolayta, Gamo, Afar. cHousewife, student.

Clinical Factors of the Respondents

The mean age for the onset of epilepsy was 19 (±SD=10) years. Regarding the duration of the illness, 272 (62%) had 11 and above years. The majority of the participants, 307 (69.9%) were under monotherapy, and 165 (37.6%) had one or more seizure attack per month. The mean (SD) AED adherence and having AED adverse effects were 16±3 and 36±9, respectively. Of the respondents, 158 (36%), and 155 (35.3%) had depression and anxiety symptoms, respectively. About 55 (12.5%) of the participants had additional diagnosis of medical illness (Table 2).

Table 2

Description of Clinical Characteristics of Patients with Epilepsy at Amanuel Mental Specialized Hospital, Addis Ababa, Ethiopia, 2019 (N=439)

Variables	Category	Frequency	Percentage/Mean
Age of onset (mean ±SD)			19.73±10.42
Medication adherence (mean ±SD)			16.37±3.76
Side effect of AED (mean ±SD)			36.67±9.47
Duration of illness	≤5 years	75	17
	6–10 years	92	21
	≥11 years	272	62
Presence of seizure per month	Absence	274	62.4
	Present	165	37.6
Drug therapy	Monotherapy	307	69.9
	Polytherapy	132	30.1
Depression	Yes	158	36
	No	281	64
Anxiety	Yes	155	35.3
	No	284	64.7
Comorbid medical diagnosisa	Yes	55	12.5
	No	384	87.5

Notes: aDiabetes mellitus, HIV/AIDS, hypertension and congestive heart failure.

Psychosocial and Substance-related Characteristics of Respondents

Regarding psychosocial characteristics of the participants, 203 (46.2%) had poor social support; 227 (51.7%) had perceived stigma (Table 3). About 135 (30.8%) of the participants were using substance user for a nonmedical purpose at the moment (Figure 1).

Table 3

Description of Psychosocial and Substance Related Characteristics of Respondents Among Patients with Epilepsy at Amanuel Mental Specialized Hospital, Addis Ababa, Ethiopia, 2019 (N=439)

Variables	Categories	Frequency	Percentage
Social support	Poor	203	46.2
	Moderate	120	27.4
	Strong	116	26.4
Perceived stigma	Stigmatized	227	51.7
	Nonstigmatized	212	48.3

Figure 1

Percentage of current substance user among patients with epilepsy at Amanuel Mental Specialized Hospital, Addis Ababa, Ethiopia, 2019 (N=439).

Mean Quality of Life Score of Participants

The overall mean (SD) score of quality of life among epilepsy patients was 60±11 with (95%CI: 59.05, 61.23). Among four domains of WHO QOL-BREF, participants scored highest in the physical domain (61±15), while the lowest mean (SD) score was for environment domain (57±15) (Table 4).

Table 4

Quality of Life Among Patients with Epilepsy at Amanuel Mental Specialized Hospital, Addis Ababa, Ethiopia, 2019 (N=439)

Domain	Mean ±SD	Percent of Participants Scored Below the Mean	95%CI
Physical	61.8±15.3	51.5%	(60.40, 63.28)
Psychological	60.1±12.8	50.1%	(58.95, 61.35)
Social	60.8±15.9	54.2%	(59.30, 62.29)
Environmental	57.7±14.7	50.1%	(56.40, 59.17)
Overall	60.1±11.6	51.7%	(59.05, 61.23)

Factors Associated with Quality of Life

Simple linear regression was carried out in relation to a number of variables which could conceivably be expected to influence quality of life. Variables with p-value <0.20 during simple linear regression analysis were selected for further analysis in multiple linear regression analysis. Duration of illness, seizure frequency, comorbid medical diagnosis, perceived stigma, level of education, marital status, occupation status, AED adherence, social support, number of antiepileptic drugs, antiepileptic drug side effect, comorbid depression and anxiety were factors associated with quality of life.

The results of multiple linear regression showed that AED side effects, AED adherence, seizure frequency, perceived stigma, depression, anxiety, and poor social support were found to be statistically significant at p-value <0.05. Based on multiple linear regression 89% of the variation of quality of life was explained by variables in the model.

A score in quality of life decreased by 0.32 for every unit increase in a score of AED side effects with (β=−0.32 95%CI: −0.38, −0.26). A score in quality of life increase by 1.24 for every unit increase in a score of AED adherence with (β=1.24, 95%CI: 1.10, 1.30). A score in quality of life decreased by 3.16 in every one month seizure attack (β=−3.16, 95%CI: −4.27, −2.04). Quality of life of epileptic patients decreased by 1.91, 3.59 in every unit increase in a score of anxiety and depressive symptoms (β=−1.91, 95%CI: -2.95, −0.86), (β=−3.59, 95%CI: –4.67, −2.52) respectively. In every unit experience of perceived stigma quality of life reduce by 2.13 (β=−2.13, 95%CI: –2.96, −1.30). Individuals with poor social support have decreased quality of life by 2.51 (β=−2.51, 95%CI: –3.62, −1.40) and those with moderate social support quality of life is reduced by 1.60 (β=−1.60, 95%CI: –2.58, −0.62) compared with strong social support (Table 5).

Table 5

Multiple Linear Regression of Quality of Life Among Patients with Epilepsy Attending at Amanuel Mental Specialized Hospital, Addis Ababa, Ethiopia, 2019

Variable		Crude β (95%CI)	Adjusted β (95%CI)
Married		Ref	Ref
Single		−2.03 (−4.20, 0.14)	−0.12 (−0.96, 0.72)
Divorced/widowed		0.17 (−3.41, 3.77)	0.21 (−1.09, 1.52)
Duration <5 years		Ref	Ref
Duration 5–10 years		1.39 (−1.28, 4.06)	−0.48 (−1.68, 0.71)
Duration ≥11 years		−1.50 (−3.74, 0.73)	−0.71 (−1.76, 0.33)
No formal education		−5.22 (−7.84, −2.61)	0.22 (−1.10, 1.55)
Primary		−0.36 (−2.77, 2.04)	0.08 (−1.21, 1.05)
Secondary		1.38 −1.00, 3.77)	−0.16 (−1.26, 0.95)
Tertiary and above		Ref	Ref
Employed		Ref	Ref
Private business		4.67 (2.27, 7.06)	0.80 (−0.23, 1.85)
Unemployed		−5.89 (−8.03, −3.75)	−0.42 (−1.46, 0.62)
Others		2.01 (−3.09, 7.12)	0.39 (−1.45, 2.25)
Side effect of AED		−0.91 (−0.99, −0.84)	−0.32 (−0.38, −0.26)*
AED adherence		2.60 (2.45, 2.76)	1.24 (1.10, 1.30)*
Drug therapy	One	Ref	Ref
	≥2	−1.87 (−4.24, 0.50)	−0.19 (−1.04, 0.64)
Presence of seizure per month	Yes	−17.88 (−19.38, −16.38)	−3.16 (−4.27, −2.04)*
	No	Ref	Ref
Perceived stigma	Yes	−6.16 (−7.67, −4.65)	−2.13 (−2.96, −1.30)*
	No	Ref	Ref
Comorbid medical illness	Yes	−4.73 (−7.99, −1.46)	0.31 (−0.81, 1.44)
	No	Ref	Ref
Depression	Yes	−16.71 (−18.35, −15.07)	−3.59 (−4.67, −2.52)**
	No	Ref	Ref
Anxiety	Yes	−15.80 (−17.53, −14.06)	−1.91 (−2.95, −0.86)*
	No	Ref	Ref
Social support	Poor	−14.53 (−16.24, −12.82)	−2.51 (−3.62, −1.40)*
	Moderate	7.09(4.73, 9.44)	−1.60 (−2.58, −0.62)**
	Strong	Ref	Ref

Notes: *p<0.001, **p<0.01. Ref, reference, adjusted R2,0.89.

Discussion

This study tried to assess quality of life and associated factors among patients with epilepsy. According to this finding, the mean quality of life score among participants was 60.14 (±SD=11.61). This result was in line with 61.49 mean score of Indian28 and 58 mean score of Ugandan17 studies.

In the current study, we had a mean higher quality of life score in epileptic patients, compared to a study conducted in Kenya (mean score of 49.90), Bhutan (mean score of 48.9), and Poland (mean score of 55.18).29–31 The possible reason for this difference might be sample size difference, clinical characteristics of the participants, sociocultural difference and study setting. The sample size was higher in this study compared to the sample of Kenya, Bhutan, and Poland. In the Kenyan study the participants use of poly AED therapy was large (54%) compared with this study (30%). Different literature has shown31–33 polytherapy receiving patients had lower mean quality of life. More than half (69%) of study participants in Poland had medical comorbidity compared with 12.5% in this study. This high comorbidity of medical illness might contribute to low mean quality of life.

However, this finding was lower than the mean score of other countries, like 74.9 in India, 70.64 in Serbia, 68.9 in Malaysia, 82 in Canada, and 66.0 in the UK.34–38 The possible reason for this better quality of life might be the availability of standard medical care, sociocultural belief and lifestyle of the patient compared with this study.

Regarding domains of quality of life, the environmental domain had low quality of life (mean score of 57.78). This result was supported by an Indian study, where the environmental domain of patients with epilepsy was mostly affected.39 In contrast, results from Ghana showed that the social domain score was the lowest mean score.40 The difference might be due to variation in belief, culture, and lifestyle factors which affects quality of life measures. Since quality of life is a subjective concept, they might perceive differently in people of different cultures.

Seizure frequency was significantly associated with quality of life. The probable explanation might be frequent seizure has been related to excess fear, feeling of stigmatization and limit their physical activity. This might lead to impairment in physical activity and psychological problems. This finding was consistent with other studies.35,36,39,41–43

Patients who had perceived stigma were negatively associated with quality of life. This result is supported by other study results,44 people with perceived stigma had a negative impact on quality of life even when seizures are controlled. In fact, people with epilepsy frequently experience rejection and isolation due to the commonly held misconception of epilepsy.45 Perceived stigma was associated with increased stress, reduced psychological functioning and patient satisfaction which indirectly affect quality of life. This result is in agreement with other studies.29,32,35,40

Epileptic patients with comorbid depression were negatively associated with quality of life. This finding was similar to results from other studies.32,35,46 This might be due to the exertion of depressed mood, hopelessness and loss of interest on a profound negative effect on quality of life. This might be also be due to the impact of depression on the patient's perception of illness, compliance with medication and use of health service.32 Screening for depression in patients with epilepsy has been recommended,47 but is still not routine. The study also revealed that patients with comorbid anxiety had a lower quality of life score. This result was supported by studies in Thailand and UK.35,48 Epileptic patients with frequent seizure had more common anxiety symptoms,49 and such a mental health issue is not addressed, It would have a negative consequence to quality of life of patients.

The result of this study showed that AED nonadherence had negatively associated with quality of life. This finding was supported by results of study in UK35 and US.50 Nonadherent patients were more likely to have experienced greater life consequence as a result of seizure.50 The possible reason could be AED nonadherence leads to worse clinical outcomes and increased frequency of seizure, which in turn derives an impaired quality of life.

Poor social support was negatively associated with quality of life. The possible reason might be the feeling of being loved and wanted contributed to provide a supportive environment which help to cope with the illness. This finding was supported by another study in Switzerland.51

AED side effects were negatively associated with quality of life. Having the side effects of AED emerged as the most important determinant of quality of life in China1 which is in agreement with this finding. The possible explanation might be the adverse effect of some AED on body weight and appearance, including hair loss, gingival hyperplasia, and polytrichia may cause a negative impact on their quality of life.

Limitation of the Study

Our cross-sectional design has prevented us from reporting the casual relationships of the associations we found. Because the data collection method was face-to-face interviews, patients might have given socially acceptable answers during the interviews, especially to substance-related questions. In addition social desirability and recall bias might have been also the other limitations. The WHOQOL-BREF tool was developed for the person suffering from chronic disease including epilepsy, but not specific for patients with epilepsy. In our study, we did not observe the effect of income on quality of life.

Conclusion and Recommendations

This study revealed that the quality of life among patients with epilepsy was moderate. Perceived stigma, having a seizure in the last one month, comorbid depression and anxiety, AED adherence, AED side effects, and poor social support were the associated factors for quality of life. It is important that quality of life assessment should be included in the patient treatment protocol which addresses psychosocial challenges that help to improve quality of life. It is better to enhance providing clinical counseling on how to cope with psychological, environmental and social challenges to achieve better health outcome. Implementing interventions that focus on early detection of comorbid psychiatric illnesses, like depression and anxiety in patients with epilepsy should be of great concern for health-care providers.