| Literature DB >> 33375068 |
Juan D Gomez1, William G P Mayner1,2, Maggie Beheler-Amass1, Giulio Tononi1, Larissa Albantakis1.
Abstract
Integrated information theory (IIT) provides a mathematical framework to characterize the cause-effect structure of a physical system and its amount of integrated information (Φ). An accompanying Python software package ("PyPhi") was recently introduced to implement this framework for the causal analysis of discrete dynamical systems of binary elements. Here, we present an update to PyPhi that extends its applicability to systems constituted of discrete, but multi-valued elements. This allows us to analyze and compare general causal properties of random networks made up of binary, ternary, quaternary, and mixed nodes. Moreover, we apply the developed tools for causal analysis to a simple non-binary regulatory network model (p53-Mdm2) and discuss commonly used binarization methods in light of their capacity to preserve the causal structure of the original system with multi-valued elements.Entities:
Keywords: binarization; causation; coarse graining; regulatory networks
Year: 2020 PMID: 33375068 DOI: 10.3390/e23010006
Source DB: PubMed Journal: Entropy (Basel) ISSN: 1099-4300 Impact factor: 2.524