Background and objectives: The histological classification and staging of thymic tumors remains a matter of debate. The correlation of computed tomography (CT) parameters with tumor histology and stage also still has to be completely assessed. The aim of this study was therefore to analyze the correlation of radiological parameters with histological and staging classifications of thymomas evaluating their prognostic role. Methods: Data of 50 patients with thymoma submitted to a complete surgical treatment between 2005 and 2015 were retrospectively analyzed. Tumors were classified according to the WHO and Suster and Moran (S&M) histological classifications and to the Masaoka-Koga and tumor, node and metastases (TNM) staging systems. The correlation of CT features with histology and stage and the prognostic role of histopathological and radiological features were assessed. Results: Five-year overall (OS) and disease-free survival (DFS) were 90.3% and 81.1%, respectively. A significant correlation of DFS with the Masaoka-Koga (p = 0.001) and TNM staging systems (p = 0.002) and with the S&M (p = 0.02) and WHO histological classifications (p = 0.04) was observed. CT scan features correlated with tumor stage, histology and prognosis. Moderately differentiated tumors (WHO B3) had a significantly higher incidence of irregular shape and contours (p = 0.002 and p = 0.001, respectively) and pericardial contact (p = 0.036). A larger tumor volume (p = 0.03) and a greater length of pleural contact (p = 0.04) adversely influenced DFS. The presence of pleural (p < 0.001) or lung invasion (p = 0.02) and of pleural effusion (p = 0.004) was associated with a significantly worse OS. Conclusions: Pre-operative CT scan parameters correlate with stage and histology, and have a prognostic role in surgically treated thymomas.
Background and objectives: The histological classification and staging of thymic tumors remains a matter of debate. The correlation of computed tomography (CT) parameters with tumor histology and stage also still has to be completely assessed. The aim of this study was therefore to analyze the correlation of radiological parameters with histological and staging classifications of thymomas evaluating their prognostic role. Methods: Data of 50 patients with thymoma submitted to a complete surgical treatment between 2005 and 2015 were retrospectively analyzed. Tumors were classified according to the WHO and Suster and Moran (S&M) histological classifications and to the Masaoka-Koga and tumor, node and metastases (TNM) staging systems. The correlation of CT features with histology and stage and the prognostic role of histopathological and radiological features were assessed. Results: Five-year overall (OS) and disease-free survival (DFS) were 90.3% and 81.1%, respectively. A significant correlation of DFS with the Masaoka-Koga (p = 0.001) and TNM staging systems (p = 0.002) and with the S&M (p = 0.02) and WHO histological classifications (p = 0.04) was observed. CT scan features correlated with tumor stage, histology and prognosis. Moderately differentiated tumors (WHO B3) had a significantly higher incidence of irregular shape and contours (p = 0.002 and p = 0.001, respectively) and pericardial contact (p = 0.036). A larger tumor volume (p = 0.03) and a greater length of pleural contact (p = 0.04) adversely influenced DFS. The presence of pleural (p < 0.001) or lung invasion (p = 0.02) and of pleural effusion (p = 0.004) was associated with a significantly worse OS. Conclusions: Pre-operative CT scan parameters correlate with stage and histology, and have a prognostic role in surgically treated thymomas.
Authors: Alexander Marx; Philipp Ströbel; Sunil S Badve; Lara Chalabreysse; John K C Chan; Gang Chen; Laurence de Leval; Frank Detterbeck; Nicolas Girard; Jim Huang; Michael O Kurrer; Libero Lauriola; Mirella Marino; Yoshihiro Matsuno; Thierry Jo Molina; Kiyoshi Mukai; Andrew G Nicholson; Daisuke Nonaka; Ralf Rieker; Juan Rosai; Enrico Ruffini; William D Travis Journal: J Thorac Oncol Date: 2014-05 Impact factor: 15.609
Authors: Enrico Ruffini; Wentao Fang; Francesco Guerrera; James Huang; Meinoshin Okumura; Dong Kwan Kim; Nicolas Girard; Andrea Billè; Souheil Boubia; Ayten Kayi Cangir; Frank Detterbeck; Conrad Falkson; Pier Luigi Filosso; Giuseppe Giaccone; Kazuya Kondo; Maurizio Infante; Marco Lucchi; Mirella Marino; Edith M Marom; Andrew G Nicholson; Andreas Rimner; Ramon Rami-Porta; Hisao Asamura Journal: J Thorac Oncol Date: 2019-11-27 Impact factor: 15.609
Authors: Martina Imbimbo; Margaret Ottaviano; Milena Vitali; Alessandra Fabbri; Giovanni Leuzzi; Michele Fiore; Davide Franceschini; Giulia Pasello; Matteo Perrino; Marco Schiavon; Giancarlo Pruneri; Angelo Paolo Dei Tos; Claudia Sangalli; Marina Chiara Garassino; Rossana Berardi; Alessandra Alessi; Giuseppina Calareso; Iacopo Petrini; Marta Scorsetti; Vieri Scotti; Lorenzo Rosso; Federico Rea; Ugo Pastorino; Paolo Giovanni Casali; Sara Ramella; Umberto Ricardi; Laura Abate-Daga; Valter Torri; Annalisa Trama; Giovannella Palmieri; Mirella Marino; Paolo Andrea Zucali Journal: Cancer Treat Rev Date: 2018-10-05 Impact factor: 12.111