INTRODUCTION: Various biomarkers based on blood counts have been useful for the prognosis of patients critically ill with COVID-19. OBJECTIVE: To describe the usefulness of the neutrophil-to-lymphocyte (NLR), monocyte-to-lymphocyte (MLR) and lymphocyte-to-platelet (LPR) ratios for the prognosis of mortality and ventilatory support requirement for COVID-19. METHOD: Retrospective cohort of clinical records of patients with COVID-19 who required hospital care. RESULTS: One-hundred and -twenty-five cases were analyzed; mean age was 51 years, and 60 % were of the male gender; 21.6 % had type 2 diabetes mellitus, and 18.4 % had hypertension. Mean leukocyte count was 9.5 x 103/µL, with a neutrophil mean of 8.0 x 103/µL. Mean NLR was 12.01, while for MLR it was 0.442, and for LPR, 373.07. Regarding the area under the curve, the following values were recorded for mortality: 0.594 for NLR, 0.628 for MLR and 0.505 for LPR; as for mechanical ventilation, the values were 0.581 for NLR, 0.619 for MLR and 0.547 for LPR. In the univariate analysis, an NLR value > 13 (OR: 2.750, p = 0.001) and an MLR of > 0.5 (OR: 2.069, p = 0.047) were associated with mortality; LPR showed no impact on mortality or respiratory support. CONCLUSION: NLR and MLR are useful for predicting mortality in patients with COVID-19. Copyright:
INTRODUCTION: Various biomarkers based on blood counts have been useful for the prognosis of patients critically ill with COVID-19. OBJECTIVE: To describe the usefulness of the neutrophil-to-lymphocyte (NLR), monocyte-to-lymphocyte (MLR) and lymphocyte-to-platelet (LPR) ratios for the prognosis of mortality and ventilatory support requirement for COVID-19. METHOD: Retrospective cohort of clinical records of patients with COVID-19 who required hospital care. RESULTS: One-hundred and -twenty-five cases were analyzed; mean age was 51 years, and 60 % were of the male gender; 21.6 % had type 2 diabetes mellitus, and 18.4 % had hypertension. Mean leukocyte count was 9.5 x 103/µL, with a neutrophil mean of 8.0 x 103/µL. Mean NLR was 12.01, while for MLR it was 0.442, and for LPR, 373.07. Regarding the area under the curve, the following values were recorded for mortality: 0.594 for NLR, 0.628 for MLR and 0.505 for LPR; as for mechanical ventilation, the values were 0.581 for NLR, 0.619 for MLR and 0.547 for LPR. In the univariate analysis, an NLR value > 13 (OR: 2.750, p = 0.001) and an MLR of > 0.5 (OR: 2.069, p = 0.047) were associated with mortality; LPR showed no impact on mortality or respiratory support. CONCLUSION: NLR and MLR are useful for predicting mortality in patients with COVID-19. Copyright:
Authors: Luis García de Guadiana-Romualdo; Carlos Rodríguez Rojas; Daniel Morell-García; David Andaluz-Ojeda; María Dolores Rodríguez Mulero; Enrique Rodríguez-Borja; Antonieta Ballesteros-Vizoso; María Dolores Calvo; Lourdes Albert-Botella; Adela Pozo Giráldez; Isabel Llompart-Alabern; Cristina Bolado Jiménez; Marta Hernández Olivo; Lucía Fernández Presa; Juan Ortega-Pérez; María José Fora Romero; Valerio Campos-Rodríguez; Andrea Ballester Férriz; Alexandra M Guiu-Martí; Leyre Pinilla Arribas; María Galindo Martínez; Edwin R Puerto-Lara; Ana Belen López Tarazaga; María Salomé Ros Braquehais; Leonor Nogales Martín; Celia Juez Santamaría; Wysalli Trapiello Fernández; Virginia Espinilla Fernández; Aleksandra Havelka; María Dolores Albaladejo-Otón Journal: Inflamm Res Date: 2021-10-30 Impact factor: 6.986
Authors: J Fabião; B Sassi; E F Pedrollo; F Gerchman; C K Kramer; C B Leitão; L C Pinto Journal: Braz J Med Biol Res Date: 2022-02-16 Impact factor: 2.590