Christina R Washington1, Kathleen N Moore. 1. Division of Obstetrics and Gynecology, Department of Gynecologic Oncology, University of Oklahoma Health Science Center, Stephenson Cancer Center, Oklahoma City, Oklahoma, USA.
Abstract
PURPOSE OF REVIEW: This article will review recent changes in the standard of care for olaparib, niraparib, and rucaparib, as well as ongoing trials evaluating this class of drugs in combination with antiangiogenic agents and PD-1/PD-L1 inhibitors. RECENT FINDINGS: Niraparib received FDA approval for use in patients with complete response or partial response to first-line platinum-based chemotherapy regardless of BRCAm or HRD status that was received in April 2020. FDA approval was received for olaparib in combination with bevacizamab for epithelial ovarian cancer patients with complete response/partial response to first-line chemotherapy and bevacizumab and g/sBRCA and/or genomic instability by Myriad myChoice CDx in May 2020. SUMMARY: In the last year, treatment with PARPi has extended to not only include BRCAm and HRD-deficient patients but also have shown improvement in outcomes in HRD-proficient patients. With these advancements, more patients can access these agents and receive benefit. In the upcoming years, it will be exciting to see the potential benefit when PARPs are added to other angiogenic antagonists and immunotherapy agents.
PURPOSE OF REVIEW: This article will review recent changes in the standard of care for olaparib, niraparib, and rucaparib, as well as ongoing trials evaluating this class of drugs in combination with antiangiogenic agents and PD-1/PD-L1 inhibitors. RECENT FINDINGS:Niraparib received FDA approval for use in patients with complete response or partial response to first-line platinum-based chemotherapy regardless of BRCAm or HRD status that was received in April 2020. FDA approval was received for olaparib in combination with bevacizamab for epithelial ovarian cancerpatients with complete response/partial response to first-line chemotherapy and bevacizumab and g/sBRCA and/or genomic instability by Myriad myChoice CDx in May 2020. SUMMARY: In the last year, treatment with PARPi has extended to not only include BRCAm and HRD-deficientpatients but also have shown improvement in outcomes in HRD-proficient patients. With these advancements, more patients can access these agents and receive benefit. In the upcoming years, it will be exciting to see the potential benefit when PARPs are added to other angiogenic antagonists and immunotherapy agents.
Authors: Matthew R Smith; Howard I Scher; Shahneen Sandhu; Eleni Efstathiou; Primo N Lara; Evan Y Yu; Daniel J George; Kim N Chi; Fred Saad; Olof Ståhl; David Olmos; Daniel C Danila; Gary E Mason; Byron M Espina; Xin Zhao; Karen A Urtishak; Peter Francis; Angela Lopez-Gitlitz; Karim Fizazi Journal: Lancet Oncol Date: 2022-02-04 Impact factor: 54.433
Authors: Juan de la Haba-Rodriguez; Ferran Ferragut Lloret; Maria Angeles Vaz Salgado; Martín Oré Arce; Ana Cardeña Gutiérrez; Jesús García-Donas Jiménez; Carmen Beato Zambrano; Rosa María Rodríguez Alonso; Rafael López López; Nuria Rodriguez Salas Journal: Clin Transl Oncol Date: 2022-04-01 Impact factor: 3.405