Lloyd Brandts1, Frans Wa van Poppel2, Piet A van den Brandt1,3. 1. GROW - School for Oncology and Developmental Biology, Department of Epidemiology, Maastricht University Medical Center, Maastricht, the Netherlands. 2. Netherlands Interdisciplinary Demographic Institute (NIDI)/Royal Netherlands Academy of Arts and Sciences (KNAW), The Hague, the Netherlands. 3. CAPHRI - School for Public Health and Primary Care, Department of Epidemiology, Maastricht University Medical Center, Maastricht, the Netherlands.
Abstract
AIM: Growing evidence suggests an association between parental longevity and lifespan of subsequent generations. We aimed to reproduce earlier findings, showing a positive association between parental longevity and offspring's longevity. Additionally, we investigated whether this is mainly driven by the maternal or paternal germline in male and female offspring. METHODS: For these analyses, data from the oldest birth cohort (1916-17) of the Netherlands Cohort Study was used. Participants filled in a baseline questionnaire in 1986 (at age 68-70 years). Follow up for vital status information until the age of 90 years (2006-07) was >99.9% complete. Multivariable-adjusted Cox regression analyses with a fixed follow-up time were based on 2368 men and 2657 women with complete parental survival data and relevant confounders to calculate risk ratios (RR) of reaching longevity. RESULTS: In age-adjusted models, paternal and maternal age at death were significantly positively associated with reaching 90 years in both male and female offspring. In male offspring, paternal age at death (≥90 years vs <80 years) showed the strongest association with survival to 90 years (RR 1.42, 95% CI 1.07-1.89), after confounder correction. In female offspring, maternal age at death (≥90 years vs <80 years) showed the strongest association with survival to 90 years (RR 1.20, 95% CI 1.04-1.40). DISCUSSION: After confounder adjustment, stronger and significant associations were observed between paternal lifespan and male offspring longevity, and maternal lifespan and female offspring longevity. Future research should investigate through which pathways a longer lifespan of parents is transmitted to their offspring. Geriatr Gerontol Int 2021; 21: 215-221.
AIM: Growing evidence suggests an association between parental longevity and lifespan of subsequent generations. We aimed to reproduce earlier findings, showing a positive association between parental longevity and offspring's longevity. Additionally, we investigated whether this is mainly driven by the maternal or paternal germline in male and female offspring. METHODS: For these analyses, data from the oldest birth cohort (1916-17) of the Netherlands Cohort Study was used. Participants filled in a baseline questionnaire in 1986 (at age 68-70 years). Follow up for vital status information until the age of 90 years (2006-07) was >99.9% complete. Multivariable-adjusted Cox regression analyses with a fixed follow-up time were based on 2368 men and 2657 women with complete parental survival data and relevant confounders to calculate risk ratios (RR) of reaching longevity. RESULTS: In age-adjusted models, paternal and maternal age at death were significantly positively associated with reaching 90 years in both male and female offspring. In male offspring, paternal age at death (≥90 years vs <80 years) showed the strongest association with survival to 90 years (RR 1.42, 95% CI 1.07-1.89), after confounder correction. In female offspring, maternal age at death (≥90 years vs <80 years) showed the strongest association with survival to 90 years (RR 1.20, 95% CI 1.04-1.40). DISCUSSION: After confounder adjustment, stronger and significant associations were observed between paternal lifespan and male offspring longevity, and maternal lifespan and female offspring longevity. Future research should investigate through which pathways a longer lifespan of parents is transmitted to their offspring. Geriatr Gerontol Int 2021; 21: 215-221.
Authors: Daria A Kashtanova; Anastasiia N Taraskina; Veronika V Erema; Anna A Akopyan; Mikhail V Ivanov; Irina D Strazhesko; Alexandra I Akinshina; Vladimir S Yudin; Valentin V Makarov; Sergey A Kraevoy; Denis E Korolev; Irina V Tarasova; Olga A Beloshevskaya; Elen A Mkhitaryan; Olga N Tkacheva; Sergey M Yudin Journal: Int J Environ Res Public Health Date: 2022-07-04 Impact factor: 4.614