Dongming Liu1,2,3,4,5, Yuan Wei2, Yangyu Zhao2, Rong Li1,2,3,4,5, Jie Yan1,2,3,4,5, Jie Qiao1,2,3,4,5. 1. Reproductive Medical Center, Peking University Third Hospital, Beijing, China. 2. Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China. 3. Key Laboratory of Assisted Reproduction, Ministry of Education, Beijing, China. 4. Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproduction, Beijing, China. 5. Research Units of Comprehensive Diagnosis and Treatment of Oocyte Maturation Arrest, Chinese Academy of Medical Sciences, Beijing, China.
Abstract
OBJECTIVE: To investigate whether thyroid cancer survivors would have increased risks of adverse obstetric outcomes. METHODS: Data from 154 patients with a history of thyroid cancer who gave a live birth at Peking University Third Hospital from January 2012 to December 2019 were collected. The control group consisted of 308 women without any thyroid disease or malignant tumor. Age and year of delivery were matched between the two groups. RESULTS: Serum levels of TSH and free T4 were significantly lower and higher in thyroid cancer patients respectively (p<0.001). After adjusted for age, pre-pregnancy BMI, pre-pregnancy hypertension, pre-pregnancy diabetes mellitus, previous cesarean section and conception by IVF/ICSI, adverse obstetric outcomes including preterm birth (OR=0.73[0.32-1.67]), low birth weight infant (OR=1.05[0.44-2.50]), gestational diabetes mellitus (OR=0.86[0.54-1.39]), preeclampsia (OR=1.11[0.34-3.57]) showed no differences between thyroid cancer survivors and the control group. However, pregnant women with a thyroid cancer history had a higher risk of abnormally invasive placentation(OR=10.57[1.22-91.97], p=0.032). CONCLUSION: Though the thyroid function status of thyroid cancer patients was different from normal pregnant women, they would not be at a higher risk of most adverse obstetric outcomes except for abnormally invasive placentation. This article is protected by copyright. All rights reserved.
OBJECTIVE: To investigate whether thyroid cancer survivors would have increased risks of adverse obstetric outcomes. METHODS: Data from 154 patients with a history of thyroid cancer who gave a live birth at Peking University Third Hospital from January 2012 to December 2019 were collected. The control group consisted of 308 women without any thyroid disease or malignant tumor. Age and year of delivery were matched between the two groups. RESULTS: Serum levels of TSH and free T4 were significantly lower and higher in thyroid cancerpatients respectively (p<0.001). After adjusted for age, pre-pregnancy BMI, pre-pregnancy hypertension, pre-pregnancy diabetes mellitus, previous cesarean section and conception by IVF/ICSI, adverse obstetric outcomes including preterm birth (OR=0.73[0.32-1.67]), low birth weight infant (OR=1.05[0.44-2.50]), gestational diabetes mellitus (OR=0.86[0.54-1.39]), preeclampsia (OR=1.11[0.34-3.57]) showed no differences between thyroid cancer survivors and the control group. However, pregnant women with a thyroid cancer history had a higher risk of abnormally invasive placentation(OR=10.57[1.22-91.97], p=0.032). CONCLUSION: Though the thyroid function status of thyroid cancerpatients was different from normal pregnant women, they would not be at a higher risk of most adverse obstetric outcomes except for abnormally invasive placentation. This article is protected by copyright. All rights reserved.