Patricia L Hudson1,2, Wodan Ling3, Michael C Wu3, Matthew R Hayward4, Alissa J Mitchell2, Joseph Larson3, Katherine A Guthrie3, Susan D Reed5, Douglas S Kwon4,6, Caroline M Mitchell1,2. 1. Department of Obstetrics and Gynecology, Massachusetts General Hospital, Boston, Massachusetts, USA. 2. Vincent Center for Reproductive Biology, Massachusetts General Hospital, Boston, Massachusetts, USA. 3. Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA. 4. Ragon Institute of MIT, MGH, and Harvard, Cambridge, Massachusetts, USA. 5. Department of Obstetrics and Gynecology, University of Washington, Seattle, Washington, USA. 6. Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts, USA.
Abstract
BACKGROUND: We compared vaginal microbial communities in postmenopausal black and white women. METHODS: Shotgun sequencing of vaginal swabs from postmenopausal women self-identified as black or white was compared using MiRKAT. RESULTS: Vaginal community dominance by Lactobacillus crispatus or Lactobacillusgasseri was more common in 44 postmenopausal black women (n = 12, 27%) than among 44 matched white women (n = 2, 5%; P = .01). No individual taxa were significantly more abundant in either group. CONCLUSIONS: We identified small overall differences in vaginal microbial communities of black and white postmenopausal women. L. crispatus dominance was more common in black women. CLINICAL TRIALS REGISTRATION: NCT02516202 (MsFLASH05) and NCT01418209 (MsFLASH03).
BACKGROUND: We compared vaginal microbial communities in postmenopausal black and white women. METHODS: Shotgun sequencing of vaginal swabs from postmenopausal women self-identified as black or white was compared using MiRKAT. RESULTS: Vaginal community dominance by Lactobacillus crispatus or Lactobacillusgasseri was more common in 44 postmenopausal black women (n = 12, 27%) than among 44 matched white women (n = 2, 5%; P = .01). No individual taxa were significantly more abundant in either group. CONCLUSIONS: We identified small overall differences in vaginal microbial communities of black and white postmenopausal women. L. crispatus dominance was more common in black women. CLINICAL TRIALS REGISTRATION: NCT02516202 (MsFLASH05) and NCT01418209 (MsFLASH03).
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