Cep Juli1, Lisda Amalia1, Uni Gamayani1, Nur Atik2. 1. Department of Neurology, Dr. Hasan Sadikin General Hospital/Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia. 2. Department of Biomedical Sciences, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia.
Abstract
PURPOSE: D-dimer is one of the main coagulation factors that plays a role in some diseases. Cerebral venous thrombosis (CVT) is a rare cerebrovascular disease with various clinical presentations, and the D-dimer might contribute to its clinical progress. Our study's objective was to explore the association between D-dimer level and focal neurological deficits in selected CVT patients. PATIENTS AND METHODS: The patients' data were retrospectively enrolled if they showed venous thrombus features in the digital subtraction angiography examination. Data collected were then evaluated using appropriate statistical tests. RESULTS: In a total of 30 patients, 24 patients had focal neurological deficits with abnormal D-dimer (mean 1.13±1.359 mg/L). We continued analysis to determine the association between the visual analog scale (VAS), a tool to measure the patient's pain, and coagulation factors. There was no significant association between the VAS score and all the coagulation factors. Interestingly, a positive association was found between focal neurological deficits and abnormal D-dimer levels (p=0.009). CONCLUSION: The abnormality of D-dimer levels in CVT's patients associates with the incidence of focal neurological deficits.
PURPOSE: D-dimer is one of the main coagulation factors that plays a role in some diseases. Cerebral venous thrombosis (CVT) is a rare cerebrovascular disease with various clinical presentations, and the D-dimer might contribute to its clinical progress. Our study's objective was to explore the association between D-dimer level and focal neurological deficits in selected CVT patients. PATIENTS AND METHODS: The patients' data were retrospectively enrolled if they showed venous thrombus features in the digital subtraction angiography examination. Data collected were then evaluated using appropriate statistical tests. RESULTS: In a total of 30 patients, 24 patients had focal neurological deficits with abnormal D-dimer (mean 1.13±1.359 mg/L). We continued analysis to determine the association between the visual analog scale (VAS), a tool to measure the patient's pain, and coagulation factors. There was no significant association between the VAS score and all the coagulation factors. Interestingly, a positive association was found between focal neurological deficits and abnormal D-dimer levels (p=0.009). CONCLUSION: The abnormality of D-dimer levels in CVT's patients associates with the incidence of focal neurological deficits.
Authors: Gustavo Saposnik; Fernando Barinagarrementeria; Robert D Brown; Cheryl D Bushnell; Brett Cucchiara; Mary Cushman; Gabrielle deVeber; Jose M Ferro; Fong Y Tsai Journal: Stroke Date: 2011-02-03 Impact factor: 7.914
Authors: Mirjam R Heldner; Susanna M Zuurbier; Bojun Li; Rascha Von Martial; Joost C M Meijers; Rebekka Zimmermann; Bastian Volbers; Simon Jung; Marwan El-Koussy; Urs Fischer; Hans P Kohler; Verena Schroeder; Jonathan M Coutinho; Marcel Arnold Journal: Neurology Date: 2020-06-23 Impact factor: 9.910