Literature DB >> 33363890

A case report of a drug-induced liver injury (DILI) caused by multiple antidepressants with causality established by the updated Roussel Uclaf causality assessment method (RUCAM) and in vitro testing.

Miguel González-Muñoz1, Jaime Monserrat Villatoro2, Eva Marín-Serrano3, Stefan Stewart2, Belén Bardón Rivera4, Jesús Marín4, Lucía Martínez de Soto2, Enrique Seco Meseguer2, Elena Ramírez2.   

Abstract

A 56-year-old female patient was hospitalized because of a lack of response and poor tolerance to multiple antidepressants, which included an episode of DILI. During hospitalization, the patient suffered another episode of DILI. Causality was assessed both by RUCAM and Lymphocyte Transformation Test, allowing to identify a safer medication.
© 2020 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd.

Entities:  

Keywords:  Roussel Uclaf Causality Assessment Method (RUCAM); antidepressants; causality assessment; drug‐induced liver injury (DILI); lymphocyte transformation test (LTT); pharmacovigilance

Year:  2020        PMID： 33363890      PMCID： PMC7752543          DOI： 10.1002/ccr3.3348

Source DB:  PubMed          Journal:  Clin Case Rep        ISSN： 2050-0904


  2 in total

1.  Utility of Lymphocyte Transformation Test for Assisting Updated Roussel Uclaf Causality Assessment Method in Drug-Induced Liver Injury: A Case-Control Study.

Authors:  Amelia Rodríguez; Irene García-García; Lucía Martínez de Soto; Arturo Gómez López De Las Huertas; Alberto M Borobia; Andrea González-Torbay; Ibtissam Akatbach-Bousaid; Miguel González-Muñoz; Elena Ramírez
Journal:  Front Pharmacol       Date:  2022-03-10       Impact factor: 5.810

2.  Antipsychotic Drug Aripiprazole Protects Liver Cells from Oxidative Stress.

Authors:  Barbara Kramar; Tinkara Pirc Marolt; Maria Monsalve; Dušan Šuput; Irina Milisav
Journal:  Int J Mol Sci       Date:  2022-07-27       Impact factor: 6.208
  2 in total

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