| Literature DB >> 33362542 |
Abstract
The human coronavirus (HCoV), SARS-CoV-2, caused more than 34 M confirmed infections from which more than 1 M deaths are reported until now (the WHO situation report-154). The current pandemic causes severe socio-economic burden. Due to the importance of understanding of the mode of recognition and viral entry, spike protein shed drug designers as the first look protein target with the first released solved structure on 26 February 2020 (PDB ID: 6VSB). It is proposed that the recognition site for GRP78 is found in SARS-CoV-2 and the immersed human coronaviruses but experimental validation is still required.Entities:
Keywords: COVID-19; GRP78; HSPA5; SARS-CoV-2; cross-vaccination; host-cell recognition; spike; viral attachment
Year: 2020 PMID: 33362542 PMCID: PMC7759632 DOI: 10.3389/fphar.2020.577467
Source DB: PubMed Journal: Front Pharmacol ISSN: 1663-9812 Impact factor: 5.810