Literature DB >> 33361235

Health Care Worker Preferences and Perspectives on Doses per Container for 2 Lyophilized Vaccines in Senegal, Vietnam, and Zambia.

Natasha Kanagat1, Kirstin Krudwig2, Karen A Wilkins3, Sydney Kaweme3, Guissimon Phiri4, Frances D Mwansa4, Mercy Mvundura5, Joanie Robertson5, Debra Kristensen6, Abdoulaye Gueye7, Sang D Dao8, Pham Q Thai9, Huyen T Nguyen8, Thang C Tran8.   

Abstract

INTRODUCTION: Limited information exists on health care workers' (HCWs) perceptions about use of multidose vaccine vials and their preferences about doses per container (DPC). We present findings from qualitative studies conducted in Senegal, Vietnam, and Zambia to explore HCWs' behavior regarding opening vials and their perceptions and preferences for the number of doses in vials of BCG and measles-containing vaccine (MCV). Zambia and Senegal currently offer MCV in 10-dose vials and BCG in 20-dose vials; 10-dose vials are used for both vaccines in Vietnam. Unused doses in vials of these reconstituted vaccines must be discarded within 6 hours.
METHODS: Key informant interviews (KIIs) were conducted with frontline HCWs in Senegal, Vietnam, and Zambia. In Senegal and Vietnam, the KIIs were conducted as part of broader formative research; in Zambia, KIIs were conducted in control districts using 10-dose MCV vials only and in intervention districts that switched from 10- to 5-dose vials during the study. During analysis, themes common to all 3 countries were synthesized. Critical themes relevant to country contexts were also examined.
RESULTS: HCWs in all 3 countries preferred containers with fewer doses for BCG and MCV to reduce wastage and increase the likelihood of vaccinating every eligible child. HCWs in Senegal and HCWs using 10-dose vials in Zambia reported sending unvaccinated children away because not enough children were present to warrant opening a new vial. In Vietnam, where sessions are typically held monthly, and in Zambia when the 5-dose vials were used, almost all HCWs reported opening a vial of MCV for even 1 child. DISCUSSION: HCWs prefer vials with fewer DPC. Their concerns about balancing coverage and wastage influence their decisions to vaccinate every eligible child; and their perspectives are crucial to ensuring that all target populations are reached with vaccines in a timely manner. © Kanagat et al.

Entities:  

Year:  2020        PMID: 33361235      PMCID: PMC7784065          DOI: 10.9745/GHSP-D-20-00112

Source DB:  PubMed          Journal:  Glob Health Sci Pract        ISSN: 2169-575X


  9 in total

1.  Single-dose versus multi-dose vaccine vials for immunization programmes in developing countries.

Authors:  Paul K Drain; Carib M Nelson; John S Lloyd
Journal:  Bull World Health Organ       Date:  2003-11-25       Impact factor: 9.408

Review 2.  Doses per vaccine vial container: An understated and underestimated driver of performance that needs more evidence.

Authors:  Alexis Heaton; Kirstin Krudwig; Tina Lorenson; Craig Burgess; Andrew Cunningham; Robert Steinglass
Journal:  Vaccine       Date:  2017-02-03       Impact factor: 3.641

3.  What vaccine product attributes do immunization program stakeholders value? Results from interviews in six low- and middle-income countries.

Authors:  Debra D Kristensen; Kate Bartholomew; Shirley Villadiego; Kristina Lorenson
Journal:  Vaccine       Date:  2016-11-08       Impact factor: 3.641

4.  The association between intentional delay of vaccine administration and timely childhood vaccination coverage.

Authors:  Philip J Smith; Sharon G Humiston; Trish Parnell; Kirsten S Vannice; Daniel A Salmon
Journal:  Public Health Rep       Date:  2010 Jul-Aug       Impact factor: 2.792

5.  Studies of missed opportunities for immunization in developing and industrialized countries.

Authors:  S S Hutchins; H A Jansen; S E Robertson; P Evans; R J Kim-Farley
Journal:  Bull World Health Organ       Date:  1993       Impact factor: 9.408

6.  Vaccine wastage in Nigeria: An assessment of wastage rates and related vaccinator knowledge, attitudes and practices.

Authors:  Aaron S Wallace; Fred Willis; Eric Nwaze; Boubacar Dieng; Naawa Sipilanyambe; Danni Daniels; Emmanuel Abanida; Alex Gasasira; Mustapha Mahmud; Tove K Ryman
Journal:  Vaccine       Date:  2017-10-21       Impact factor: 3.641

7.  Impact of changing the measles vaccine vial size on Niger's vaccine supply chain: a computational model.

Authors:  Tina-Marie Assi; Shawn T Brown; Ali Djibo; Bryan A Norman; Jayant Rajgopal; Joel S Welling; Sheng-I Chen; Rachel R Bailey; Souleymane Kone; Hailu Kenea; Diana L Connor; Angela R Wateska; Anirban Jana; Stephen R Wisniewski; Willem G Van Panhuis; Donald S Burke; Bruce Y Lee
Journal:  BMC Public Health       Date:  2011-06-02       Impact factor: 3.295

8.  The effects of switching from 10 to 5-dose vials of MR vaccine on vaccination coverage and wastage: A mixed-method study in Zambia.

Authors:  Kirstin Krudwig; Barbara Knittel; Ali Karim; Natasha Kanagat; Wendy Prosser; Guissimon Phiri; Frances Mwansa; Robert Steinglass
Journal:  Vaccine       Date:  2020-07-21       Impact factor: 3.641

9.  Assessment of vaccine wastage rates, missed opportunities, and related knowledge, attitudes and practices during introduction of a second dose of measles-containing vaccine into Cambodia's national immunization program.

Authors:  Aaron S Wallace; Kong Krey; John Hustedt; Eleanor Burnett; Narin Choun; Danni Daniels; Margaret L Watkins; Sann Chan Soeung; Richard Duncan
Journal:  Vaccine       Date:  2018-06-19       Impact factor: 3.641

  9 in total
  2 in total

1.  Vaccine Hesitancy among Parents and Its Association with the Uptake of Measles Vaccine in Urban Settings in Khartoum State, Sudan.

Authors:  Majdi M Sabahelzain; Mohamed Moukhyer; Bart van den Borne; Hans Bosma
Journal:  Vaccines (Basel)       Date:  2022-01-28

2.  Should countries switch to using five- or ten-dose rotavirus vaccines now that they are available?

Authors:  Patrick T Wedlock; Sarah N Cox; Sarah M Bartsch; Samuel L Randall; Kelly J O'Shea; Marie C Ferguson; Sheryl S Siegmund; Bruce Y Lee
Journal:  Vaccine       Date:  2021-06-19       Impact factor: 4.169

  2 in total

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