Shuanhu Wang1, Xinxin Xu1, Jiajia Guan1, Rui Huo1, Mulin Liu2, Congqiao Jiang1, Wenbin Wang3. 1. Department of Gastrointestinal surgery, The First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui, China. 2. Department of Gastrointestinal Surgery, The First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui, China. 3. Department of General surgery, The Forth Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
Abstract
BACKGROUND/AIMS: Most studies have found that right-sided colon cancer (RCC) has worse prognosis than left-sided colon cancer (LCC), especially in stage III, but the reported prognosis of stage II colon cancer is variable. This study aimed to evaluate the impact of tumor location on survival outcomes in stage II colon cancer. MATERIALS AND METHODS: Patients with stage II colon cancer were identified in the Surveillance, Epidemiology, and End Results database from 2004 to 2009. The effect of tumor location on overall survival and cancer-specific survival was analyzed using Cox proportional hazards regression models and propensity score matching. RESULTS: Of 16,519 patients, 69.6% had RCC and30.4% had LCC. In unadjusted analyses, RCC had a 13% increased overall mortality risk (hazards ratio [HR], 1.13; 95% confidence interval [CI], 1.07-1.19; p<0.001) but an18% reduction in cancer-specific mortality risk compared with LCC (HR, 0.82; 95% CI, 0.76-0.89; p<0.001). After propensity scores matching analyses, RCC had a 21% reduced overall mortality risk (HR, 0.79; 95% CI, 0.72-0.87; p<0.001) and a 49% reduction in cancer-specific mortality risk compared with LCC (HR, 0.51; 95% CI, 0.44-0.60; p<0.001). CONCLUSION: When adjusted for multiple clinicopathological features, stage II RCC showed better prognosis than stage II LCC.
BACKGROUND/AIMS: Most studies have found that right-sided colon cancer (RCC) has worse prognosis than left-sided colon cancer (LCC), especially in stage III, but the reported prognosis of stage II colon cancer is variable. This study aimed to evaluate the impact of tumor location on survival outcomes in stage II colon cancer. MATERIALS AND METHODS:Patients with stage II colon cancer were identified in the Surveillance, Epidemiology, and End Results database from 2004 to 2009. The effect of tumor location on overall survival and cancer-specific survival was analyzed using Cox proportional hazards regression models and propensity score matching. RESULTS: Of 16,519 patients, 69.6% had RCC and30.4% had LCC. In unadjusted analyses, RCC had a 13% increased overall mortality risk (hazards ratio [HR], 1.13; 95% confidence interval [CI], 1.07-1.19; p<0.001) but an18% reduction in cancer-specific mortality risk compared with LCC (HR, 0.82; 95% CI, 0.76-0.89; p<0.001). After propensity scores matching analyses, RCC had a 21% reduced overall mortality risk (HR, 0.79; 95% CI, 0.72-0.87; p<0.001) and a 49% reduction in cancer-specific mortality risk compared with LCC (HR, 0.51; 95% CI, 0.44-0.60; p<0.001). CONCLUSION: When adjusted for multiple clinicopathological features, stage II RCC showed better prognosis than stage II LCC.
Authors: Monica M Bertagnolli; Mark Redston; Carolyn C Compton; Donna Niedzwiecki; Robert J Mayer; Richard M Goldberg; Thomas A Colacchio; Leonard B Saltz; Robert S Warren Journal: J Clin Oncol Date: 2011-07-11 Impact factor: 44.544
Authors: E Missiaglia; B Jacobs; G D'Ario; A F Di Narzo; C Soneson; E Budinska; V Popovici; L Vecchione; S Gerster; P Yan; A D Roth; D Klingbiel; F T Bosman; M Delorenzi; S Tejpar Journal: Ann Oncol Date: 2014-07-23 Impact factor: 32.976
Authors: Javier A Cienfuegos; Jorge Baixauli; Jorge Arredondo; Carlos Pastor; Patricia Martínez Ortega; Gabriel Zozaya; Pablo Martí-Cruchaga; José Luis Hernández Lizoáin Journal: Rev Esp Enferm Dig Date: 2018-03 Impact factor: 2.086