Yuwen Zhou1, Ruolan Xia1, Huilang Xiao2, Dan Pu3, Yixiu Long1, Zhenyu Ding4, Jiyan Liu5, Xuelei Ma6. 1. Department of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu, China; West China School of Medicine, Sichuan University, Chengdu, China. 2. Sichuan Aerospace System Engineering Institute, Chengdu, China. 3. Lung Cancer Center, West China Hospital, Sichuan University, Chengdu, China. 4. Department of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu, China. Electronic address: dingzhenyu@scu.edu.cn. 5. Department of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu, China. Electronic address: liujiyan1972@163.com. 6. Department of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu, China. Electronic address: drmaxuelei@gmail.com.
Abstract
BACKGROUND: Thyroid function abnormality (TFA) is a common immune-related adverse event (irAEs), but the association between it and the efficacy of programmed cell death protein 1 (PD-1) inhibitor in advanced non-small cell lung cancer (NSCLC) is finitely understood. MATERIALS AND METHODS: We conducted a single center, retrospective study of advanced NSCLC patients who were treated with PD-1 inhibitors between 10 October 2016 and 1 April 2020. TFA was characterized as new onset subclinical hypothyroidism, overt hypothyroidism, subclinical hyperthyroidism and overt hyperthyroidism. Frequency of development of TFA-irAEs, and its relationship with overall survival (OS) and progression free survival (PFS) were evaluated. RESULTS: In our study, 191 patients were treated with PD-1 inhibitors. Among them, forty patients (20.9%) developed TFA, of whom 10 (5.2%) presented with subclinical hypothyroidism, 15 (7.9%) with overt hypothyroidism, 6 (3.1%) with subclinical hyperthyroidism and 9 (4.7%) with overt hyperthyroidism. Survival analysis showed that the OS (16.8 months vs. 11.1 months, p < 0.001) and PFS (10.4 months vs. 5.5 months, p < 0.001) were significantly longer in patients with TFA-irAEs than in those without TFA-irAEs. In subgroup analysis of hypothyroidism and hyperthyroidism groups, similar trends were also obtained for both OS and PFS. After adjusting for potential confounding variables, patients with TFA-irAEs had a lower mortality risk (HR 0.334, 95%CI 0.196-0.571) than those without TFA-irAEs. CONCLUSIONS: TFA-irAEs is associated with enhanced PD-1 inhibitor efficacy in advanced NSCLC patients and it may be a biomarker for antitumor immune response.
BACKGROUND: Thyroid function abnormality (TFA) is a common immune-related adverse event (irAEs), but the association between it and the efficacy of programmed cell death protein 1 (PD-1) inhibitor in advanced non-small cell lung cancer (NSCLC) is finitely understood. MATERIALS AND METHODS: We conducted a single center, retrospective study of advanced NSCLCpatients who were treated with PD-1 inhibitors between 10 October 2016 and 1 April 2020. TFA was characterized as new onset subclinical hypothyroidism, overt hypothyroidism, subclinical hyperthyroidism and overt hyperthyroidism. Frequency of development of TFA-irAEs, and its relationship with overall survival (OS) and progression free survival (PFS) were evaluated. RESULTS: In our study, 191 patients were treated with PD-1 inhibitors. Among them, forty patients (20.9%) developed TFA, of whom 10 (5.2%) presented with subclinical hypothyroidism, 15 (7.9%) with overt hypothyroidism, 6 (3.1%) with subclinical hyperthyroidism and 9 (4.7%) with overt hyperthyroidism. Survival analysis showed that the OS (16.8 months vs. 11.1 months, p < 0.001) and PFS (10.4 months vs. 5.5 months, p < 0.001) were significantly longer in patients with TFA-irAEs than in those without TFA-irAEs. In subgroup analysis of hypothyroidism and hyperthyroidism groups, similar trends were also obtained for both OS and PFS. After adjusting for potential confounding variables, patients with TFA-irAEs had a lower mortality risk (HR 0.334, 95%CI 0.196-0.571) than those without TFA-irAEs. CONCLUSIONS:TFA-irAEs is associated with enhanced PD-1 inhibitor efficacy in advanced NSCLCpatients and it may be a biomarker for antitumor immune response.
Authors: Mario Giovanni Chilelli; Carlo Signorelli; Julio Rodrigo Giron Berrios; Angelo Onorato; Fabrizio Nelli; Maria Agnese Fabbri; Francesca Primi; Eleonora Marrucci; Antonella Virtuoso; Marta Schirripa; Marco Mazzotta; Enzo Maria Ruggeri Journal: Cancer Diagn Progn Date: 2022-01-03
Authors: Rossella Rubino; Andrea Marini; Giandomenico Roviello; Elena Margherita Presotto; Isacco Desideri; Isabella Ciardetti; Marco Brugia; Nicola Pimpinelli; Lorenzo Antonuzzo; Enrico Mini; Lorenzo Livi; Mario Maggi; Alessandro Peri Journal: Endocrine Date: 2021-05-25 Impact factor: 3.633