Weili Zheng1, Geeth Kavya Minama Reddy2, Falcon Dai2, Ayushi Chandramani2, David Brang3, Scott Hunter4, Michael H Kohrman5, Sandra Rose2, Marvin Rossi6, James Tao2, Shasha Wu2, Richard Byrne7, David M Frim8, Peter Warnke8, Vernon L Towle9. 1. Department of Engineering, The University of Illinois, Chicago, IL, USA. 2. Department of Neurology, The University of Chicago, Chicago, IL, USA. 3. Department of Psychology, University of Michigan, Ann Arbor, MI, USA. 4. Department of Psychiatry and Behavioral Neuroscience, The University of Chicago, Chicago, IL, USA. 5. Department of Pediatrics, The University of Chicago, Chicago, IL 60487, USA. 6. Department of Neurology, Rush University, Chicago, IL, USA. 7. Department of Surgery, Rush University, Chicago, IL, USA. 8. Department of Surgery, The University of Chicago, 5841 S. Maryland Ave, 60487 Chicago, IL, USA. 9. Department of Neurology, The University of Chicago, Chicago, IL, USA. Electronic address: towle@uchicago.edu.
Abstract
OBJECTIVE: To describe the spatio-temporal dynamics and interactions during linguistic and memory tasks. METHODS: Event-related electrocorticographic (ECoG) spectral patterns obtained during cognitive tasks from 26 epilepsy patients (aged: 9-60 y) were analyzed in order to examine the spatio-temporal patterns of activation of cortical language areas. ECoGs (1024 Hz/channel) were recorded from 1567 subdural electrodes and 510 depth electrodes chronically implanted over or within the frontal, parietal, occipital and/or temporal lobes as part of their surgical work-up for intractable seizures. Six language/memory tasks were performed, which required responding verbally to auditory or visual word stimuli. Detailed analysis of electrode locations allowed combining results across patients. RESULTS: Transient increases in induced ECoG gamma power (70-100 Hz) were observed in response to hearing words (central superior temporal gyrus), reading text and naming pictures (occipital and fusiform cortex) and speaking (pre-central, post-central and sub-central cortex). CONCLUSIONS: Between these activations there was widespread spatial divergence followed by convergence of gamma activity that reliably identified cortical areas associated with task-specific processes. SIGNIFICANCE: The combined dataset supports the concept of functionally-specific locally parallel language networks that are widely distributed, partially interacting in succession to serve the cognitive and behavioral demands of the tasks.
OBJECTIVE: To describe the spatio-temporal dynamics and interactions during linguistic and memory tasks. METHODS: Event-related electrocorticographic (ECoG) spectral patterns obtained during cognitive tasks from 26 epilepsypatients (aged: 9-60 y) were analyzed in order to examine the spatio-temporal patterns of activation of cortical language areas. ECoGs (1024 Hz/channel) were recorded from 1567 subdural electrodes and 510 depth electrodes chronically implanted over or within the frontal, parietal, occipital and/or temporal lobes as part of their surgical work-up for intractable seizures. Six language/memory tasks were performed, which required responding verbally to auditory or visual word stimuli. Detailed analysis of electrode locations allowed combining results across patients. RESULTS: Transient increases in induced ECoG gamma power (70-100 Hz) were observed in response to hearing words (central superior temporal gyrus), reading text and naming pictures (occipital and fusiform cortex) and speaking (pre-central, post-central and sub-central cortex). CONCLUSIONS: Between these activations there was widespread spatial divergence followed by convergence of gamma activity that reliably identified cortical areas associated with task-specific processes. SIGNIFICANCE: The combined dataset supports the concept of functionally-specific locally parallel language networks that are widely distributed, partially interacting in succession to serve the cognitive and behavioral demands of the tasks.