Dinh van Nguyen1,2,3,4, Hieu Chi Chu5, Christopher Vidal3, Richard B Fulton4, Nguyet Nhu Nguyen5, Nga Thi Quynh Do6, Tu Linh Tran7, Thuy Ninh Nguyen7, Ha Thi Thu Nguyen8, Hanh Hong Chu9, Huyen Thi Thanh Thuc9, Huong Thi Minh Le9, Sheryl van Nunen3,10, Janet Anderson4, Suran L Fernando3,4,10. 1. Vinmec Healthcare System, Hanoi, 100000, Vietnam. 2. College of Health Science, VinUniversity, Hanoi, 100000, Vietnam. 3. Sydney Medical School - Northern, The University of Sydney, Sydney, 2065, Australia. 4. ImmunoRheumatology Laboratory, NSW Health Pathology-North, Royal North Shore Hospital, Sydney, 2065, Australia. 5. Center of Allergology & Clinical Immunology, Bach Mai Hospital, Hanoi, 115000, Vietnam. 6. Department of Immunology & Molecular Biology, National Institute of Hygiene & Epidemiology, Hanoi, 100000, Vietnam. 7. Hanoi Heart Hospital, Hanoi, 100000, Vietnam. 8. Department of Allergy & Clinical Immunology, Hanoi Medical University, Hanoi, 100000, Vietnam. 9. Department of Allergy, Immunology & Rheumatology, National Hospital of Pediatrics, Hanoi, 100000, Vietnam. 10. Department of Clinical immunology & Allergy, Royal North Shore Hospital, Sydney, 2065, Australia.
Abstract
Aims: To determine genetic susceptibility markers for carbamazepine (CBZ) and allopurinol-induced severe cutaneous adverse reactions (SCARs) in Vietnamese. Methods: A case-control study was performed involving 122 patients with CBZ or allopurinol-induced SCARs and 120 drug tolerant controls. Results: HLA-B*58:01 was strongly associated with allopurinol-induced SCARs and strongly correlated with SNP rs9263726. HLA-B*15:02 was associated with CBZ-induced Stevens-Johnson syndrome/toxic epidermal necrolysis but not with drug-induced hypersensitivity syndrome/drug rash with eosinophilia and systemic symptoms. No association was found between HLA-A*31:01 and CBZ-induced SCARs. HLA-B*58:01 and rs3909184 allele A with renal insufficiency were shown to increase the risk of allopurinol-induced SCARs. Conclusion: HLA-B*58:01 and HLA-B*15:02 confer susceptibility to allopurinol-induced SCARs and CBZ-induced SJS/TEN in Vietnamese. SNP rs9263726 can be used as a surrogate marker in identifying HLA-B*58:01.
Aims: To determine genetic susceptibility markers for carbamazepine (CBZ) and allopurinol-induced severe cutaneous adverse reactions (SCARs) in Vietnamese. Methods: A case-control study was performed involving 122 patients with CBZ or allopurinol-induced SCARs and 120 drug tolerant controls. Results:HLA-B*58:01 was strongly associated with allopurinol-induced SCARs and strongly correlated with SNP rs9263726. HLA-B*15:02 was associated with CBZ-induced Stevens-Johnson syndrome/toxic epidermal necrolysis but not with drug-induced hypersensitivity syndrome/drug rash with eosinophilia and systemic symptoms. No association was found between HLA-A*31:01 and CBZ-induced SCARs. HLA-B*58:01 and rs3909184 allele A with renal insufficiency were shown to increase the risk of allopurinol-induced SCARs. Conclusion:HLA-B*58:01 and HLA-B*15:02 confer susceptibility to allopurinol-induced SCARs and CBZ-induced SJS/TEN in Vietnamese. SNP rs9263726 can be used as a surrogate marker in identifying HLA-B*58:01.
Entities:
Keywords:
DRESS; HLA; SJS/TEN; Vietnamese; allopurinol; carbamazepine; severe cutaneous adverse drug reactions