Literature DB >> 3335520

Botulinum C2 toxin ADP-ribosylates cytoplasmic beta/gamma-actin in arginine 177.

J Vandekerckhove1, B Schering, M Bärmann, K Aktories.   

Abstract

Isolated cytoplasmic actin of human platelet and pig liver actin, but not rabbit skeletal muscle actin, was ADP-ribosylated by botulinum C2 toxin in the presence of [32P]NAD. Tryptic digestion of the [32P]ADP-ribosylated platelet actin generated two labeled peptides: a soluble peptide covering residues 174-183 and an insoluble fragment containing residues 148-183. Further digestion of these two peptides with thermolysin yielded the same radioactive peptide, which was in both cases peptide 175-177. Amino acid sequence analysis of peptides 174-183 and 175-177 located the ADP-ribosylation on Arg177.

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Year:  1988        PMID： 3335520

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  46 in total

1.  The golgi-associated COPI-coated buds and vesicles contain beta/gamma -actin.

Authors:  F Valderrama; A Luna; T Babía; J A Martinez-Menárguez; J Ballesta; H Barth; C Chaponnier; J Renau-Piqueras; G Egea
Journal:  Proc Natl Acad Sci U S A       Date:  2000-02-15       Impact factor: 11.205

2.  Regulation of somatodendritic GABAA receptor channels in rat hippocampal neurons: evidence for a role of the small GTPase Rac1.

Authors:  D K Meyer; C Olenik; F Hofmann; H Barth; J Leemhuis; I Brünig; K Aktories; W Nörenberg
Journal:  J Neurosci       Date:  2000-09-15       Impact factor: 6.167

3.  Adenosine diphosphate-ribosylation of G-actin by botulinum C2 toxin increases endothelial permeability in vitro.

Authors:  N Suttorp; M Polley; J Seybold; H Schnittler; W Seeger; F Grimminger; K Aktories
Journal:  J Clin Invest       Date:  1991-05       Impact factor: 14.808

Review 4.  Targeting of the actin cytoskeleton by insecticidal toxins from Photorhabdus luminescens.

Authors:  Alexander E Lang; Gudula Schmidt; Joel J Sheets; Klaus Aktories
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2010-11-12       Impact factor: 3.000

Review 5.  Exploring the role of host cell chaperones/PPIases during cellular up-take of bacterial ADP-ribosylating toxins as basis for novel pharmacological strategies to protect mammalian cells against these virulence factors.

Authors:  Holger Barth
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2010-12-01       Impact factor: 3.000

Review 6.  Clostridial ADP-ribosyltransferases--modification of low molecular weight GTP-binding proteins and of actin by clostridial toxins.

Authors:  K Aktories
Journal:  Med Microbiol Immunol       Date:  1990       Impact factor: 3.402

7.  Inhibition of the contraction of the isolated longitudinal muscle of the guinea-pig ileum by botulinum C2 toxin: evidence for a role of G/F-actin transition in smooth muscle contraction.

Authors:  S Mauss; G Koch; V A Kreye; K Aktories
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1989-09       Impact factor: 3.000

Review 8.  C3 exoenzymes, novel insights into structure and action of Rho-ADP-ribosylating toxins.

Authors:  Martin Vogelsgesang; Alexander Pautsch; Klaus Aktories
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2006-12-05       Impact factor: 3.000

9.  Cytotoxic effects by microinjection of ADP-ribosylated skeletal muscle G-actin in PtK2 cells in the absence of Clostridium perfringens iota toxin.

Authors:  G Kiefer; M Lerner; P Sehr; I Just; K Aktories
Journal:  Med Microbiol Immunol       Date:  1996-02       Impact factor: 3.402

10.  ADP-ribosylation of Drosophila indirect-flight-muscle actin and arthrin by Clostridium botulinum C2 toxin and Clostridium perfringens iota toxin.

Authors:  I Just; E S Hennessey; D R Drummond; K Aktories; J C Sparrow
Journal:  Biochem J       Date:  1993-04-15       Impact factor: 3.857
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