Sibtain Anwar1, Ben O' Brien2. 1. Department of Perioperative Medicine, Barts Heart Centre and St Bartholomew's Hospital, London, UK; William Harvey Research Institute, Barts, London School of Medicine, Queen Mary University of London, London, UK; Outcomes Research Consortium, Cleveland Clinic. Electronic address: s.anwar@qmul.ac.uk. 2. Department of Perioperative Medicine, Barts Heart Centre and St Bartholomew's Hospital, London, UK; William Harvey Research Institute, Barts, London School of Medicine, Queen Mary University of London, London, UK; Outcomes Research Consortium, Cleveland Clinic.