Literature DB >> 33352698

Advanced Glycation End Product Inhibitor Pyridoxamine Attenuates IVD Degeneration in Type 2 Diabetic Rats.

Juliane D Glaeser1,2,3,4, Derek Ju1,3, Wafa Tawackoli1,2,3,4,5,6, Jae H Yang1,7, Khosrowdad Salehi1,2, Tina Stefanovic1,2, Linda E A Kanim1,3,4, Pablo Avalos2, Giselle Kaneda1,2, Stephen Stephan1,3, Melodie F Metzger3,8, Hyun W Bae1,3,4, Dmitriy Sheyn1,2,3,4,6.   

Abstract

Type 2 diabetes mellitus (T2DM) is associated with advanced glycation end product (AGE) enrichment and considered a risk factor for intervertebral disc (IVD) degeneration. We hypothesized that systemic AGE inhibition, achieved using pyridoxamine (PM), attenuates IVD degeneration in T2DM rats. To induce IVD degeneration, lumbar disc injury or sham surgery was performed on Zucker Diabetic Sprague Dawley (ZDSD) or control Sprague Dawley (SD) rats. Post-surgery, IVD-injured ZDSD rats received daily PM dissolved in drinking water or water only. The resulting groups were SD uninjured, SD injured, ZDSD uninjured, ZDSD injured, and ZDSD injured + PM. Levels of blood glycation and disc degeneration were investigated. At week 8 post-surgery, glycated serum protein (GSP) levels were increased in ZDSDs compared to SDs. PM treatment attenuated this increase. Micro-MRI analysis demonstrated IVD dehydration in injured versus uninjured SDs and ZDSDs. In the ZDSD injured + PM group, IVD dehydration was diminished compared to ZDSD injured. AGE levels were decreased and aggrecan levels increased in ZDSD injured + PM versus ZDSD injured rats. Histological and immunohistochemical analyses further supported the beneficial effect of PM. In summary, PM attenuated GSP levels and IVD degeneration processes in ZDSD rats, demonstrating its potential to attenuate IVD degeneration in addition to managing glycemia in T2DM.

Entities:  

Keywords:  advanced glycation end products; intervertebral disc degeneration; type 2 diabetes mellitus

Mesh：

Substances：

Year:  2020        PMID： 33352698      PMCID： PMC7766438          DOI： 10.3390/ijms21249709

Source DB:  PubMed          Journal:  Int J Mol Sci        ISSN： 1422-0067            Impact factor:   5.923


  52 in total

1.  The association between lumbar disc degeneration and low back pain: the influence of age, gender, and individual radiographic features.

Authors:  Evelien I T de Schepper; Jurgen Damen; Joyce B J van Meurs; Abida Z Ginai; Maria Popham; Albert Hofman; Bart W Koes; Sita M Bierma-Zeinstra
Journal:  Spine (Phila Pa 1976)       Date:  2010-03-01       Impact factor: 3.468

2.  Effect of shear force on intervertebral disc (IVD) degeneration: an in vivo rat study.

Authors:  Jaehyun Kim; Seok-Jo Yang; Hyunchul Kim; Yoonsang Kim; Joon B Park; Candis Dubose; Tae-Hong Lim
Journal:  Ann Biomed Eng       Date:  2012-04-20       Impact factor: 3.934

Review 3.  Pyridoxamine, an inhibitor of advanced glycation and lipoxidation reactions: a novel therapy for treatment of diabetic complications.

Authors:  Thomas O Metz; Nathan L Alderson; Suzanne R Thorpe; John W Baynes
Journal:  Arch Biochem Biophys       Date:  2003-11-01       Impact factor: 4.013

4.  Characterization of the ZDSD Rat: A Translational Model for the Study of Metabolic Syndrome and Type 2 Diabetes.

Authors:  Richard G Peterson; Charles V Jackson; Karen Zimmerman; Willem de Winter; Norman Huebert; Michael K Hansen
Journal:  J Diabetes Res       Date:  2015-04-16       Impact factor: 4.011

5.  Optimization of a rat lumbar IVD degeneration model for low back pain.

Authors:  Juliane D Glaeser; Wafa Tawackoli; Derek G Ju; Jae H Yang; Linda Ea Kanim; Khosrowdad Salehi; Victoria Yu; Evan Saidara; Jean-Phillipe Vit; Zhanna Khnkoyan; Zachary NaPier; Laura S Stone; Hyun W Bae; Dmitriy Sheyn
Journal:  JOR Spine       Date:  2020-06-22

6.  Human iPSCs can be differentiated into notochordal cells that reduce intervertebral disc degeneration in a porcine model.

Authors:  Dmitriy Sheyn; Shiran Ben-David; Wafa Tawackoli; Zhengwei Zhou; Khosrawdad Salehi; Maxim Bez; Sandra De Mel; Virginia Chan; Joseph Roth; Pablo Avalos; Joseph C Giaconi; Haneen Yameen; Lena Hazanov; Dror Seliktar; Debiao Li; Dan Gazit; Zulma Gazit
Journal:  Theranostics       Date:  2019-10-12       Impact factor: 11.556

7.  Combined anti-inflammatory and anti-AGE drug treatments have a protective effect on intervertebral discs in mice with diabetes.

Authors:  Svenja Illien-Junger; Fabrizio Grosjean; Damien M Laudier; Helen Vlassara; Gary E Striker; James C Iatridis
Journal:  PLoS One       Date:  2013-05-17       Impact factor: 3.240

Review 8.  A Review of Animal Models of Intervertebral Disc Degeneration: Pathophysiology, Regeneration, and Translation to the Clinic.

Authors:  Chris Daly; Peter Ghosh; Graham Jenkin; David Oehme; Tony Goldschlager
Journal:  Biomed Res Int       Date:  2016-05-22       Impact factor: 3.411

9.  Quantitative MRI in early intervertebral disc degeneration: T1rho correlates better than T2 and ADC with biomechanics, histology and matrix content.

Authors:  Cornelis P L Paul; Theodoor H Smit; Magda de Graaf; Roderick M Holewijn; Arno Bisschop; Peter M van de Ven; Margriet G Mullender; Marco N Helder; Gustav J Strijkers
Journal:  PLoS One       Date:  2018-01-30       Impact factor: 3.240

10.  Males and females exhibit distinct relationships between intervertebral disc degeneration and pain in a rat model.

Authors:  Grace E Mosley; Minghui Wang; Philip Nasser; Alon Lai; Daniel A Charen; Bin Zhang; James C Iatridis
Journal:  Sci Rep       Date:  2020-09-15       Impact factor: 4.379
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  1 in total

Review 1.  Zucker Diabetic-Sprague Dawley (ZDSD) rat: Type 2 diabetes translational research model.

Authors:  Andrea N Wang; Joselia Carlos; Graham M Fraser; John J McGuire
Journal:  Exp Physiol       Date:  2022-03-08       Impact factor: 2.858
  1 in total

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