Bingwei Ma1,2, Hang Sun1, Bing Zhu1, Shilin Wang3, Lei Du1, Xingchun Wang1,4, Shen Qu5,6. 1. Department of Endocrinology and Metabolism, Tongji University School of Medicine, Shanghai Tenth People's Hospital Affiliated to Tongji University, Shanghai, China. 2. Department of Gastrointestinal Surgery, Tongji University School of Medicine, Shanghai Tenth People's Hospital Affiliated to Tongji University, Shanghai, China. 3. Department of Liver and Gallbladder Surgery, Tongji University School of Medicine, Shanghai Tenth People's Hospital Affiliated to Tongji University, Shanghai, China. 4. Thyroid Research Center of Shanghai, Shanghai, China. 5. Department of Endocrinology and Metabolism, Tongji University School of Medicine, Shanghai Tenth People's Hospital Affiliated to Tongji University, Shanghai, China, qushencn@hotmail.com. 6. Thyroid Research Center of Shanghai, Shanghai, China, qushencn@hotmail.com.
Abstract
BACKGROUND: Iron is closely related to metabolism. However, the relationship between iron and hepatic steatosis has not been fully elucidated. OBJECTIVE: We aimed to investigate the triangular relationship between iron and hepatic steatosis and laparoscopic sleeve gastrectomy (LSG) in patients with obesity. METHODS: A total of 297 patients with obesity and 43 healthy individuals with a normal BMI were enrolled. Eighty-two patients underwent LSG. Anthropometrics, glucose-lipid metabolic markers, and hepatic steatosis assessed by FibroScan (CAP value and E value) were measured at baseline, and again at follow-up time intervals of 6 months and 1 year after surgery. RESULTS: (1) Iron was significantly higher in patients with obesity or overweight than in the individuals with normal BMI (8.18 ± 1.47 vs. 7.46 ± 0.99 mmol/L, p = 0.002). Iron was also higher in subjects with high blood pressure, dyslipidemia, and hyperuricemia than non-corresponding disorders (all p < 0.05). Moreover, iron was significantly higher in the severe than mild or moderate non-alcoholic fatty liver disease (NAFLD) group (p = 0.046 and 0.018). (2) Iron was positively associated with body weight, BMI, waist-to-hip ratio, uric acid, liver enzymes, postprandial blood glucose, fasting insulin, HOMA-IR, triglycerides, free fatty acid, and hepatic steatosis (CAP value), and negatively associated with high-density lipoprotein cholesterol (all p < 0.05). Iron was also positively associated with the visceral adipose area in patients with obesity and negatively associated with the subcutaneous adipose area in patients with overweight (all p < 0.05). (3) Iron levels and CAP values were decreased gradually 6 months and 1 year after surgery (all p < 0.05). CONCLUSIONS: Overall, our results indicated that iron is associated with hepatic steatosis in obesity. The iron level was significantly higher in patients with severe NAFLD than with mild or moderate NAFLD. LSG may reduce iron levels while improving fat deposition in the liver.
BACKGROUND:Iron is closely related to metabolism. However, the relationship between iron and hepatic steatosis has not been fully elucidated. OBJECTIVE: We aimed to investigate the triangular relationship between iron and hepatic steatosis and laparoscopic sleeve gastrectomy (LSG) in patients with obesity. METHODS: A total of 297 patients with obesity and 43 healthy individuals with a normal BMI were enrolled. Eighty-two patients underwent LSG. Anthropometrics, glucose-lipid metabolic markers, and hepatic steatosis assessed by FibroScan (CAP value and E value) were measured at baseline, and again at follow-up time intervals of 6 months and 1 year after surgery. RESULTS: (1) Iron was significantly higher in patients with obesity or overweight than in the individuals with normal BMI (8.18 ± 1.47 vs. 7.46 ± 0.99 mmol/L, p = 0.002). Iron was also higher in subjects with high blood pressure, dyslipidemia, and hyperuricemia than non-corresponding disorders (all p < 0.05). Moreover, iron was significantly higher in the severe than mild or moderate non-alcoholic fatty liver disease (NAFLD) group (p = 0.046 and 0.018). (2) Iron was positively associated with body weight, BMI, waist-to-hip ratio, uric acid, liver enzymes, postprandial blood glucose, fasting insulin, HOMA-IR, triglycerides, free fatty acid, and hepatic steatosis (CAP value), and negatively associated with high-density lipoprotein cholesterol (all p < 0.05). Iron was also positively associated with the visceral adipose area in patients with obesity and negatively associated with the subcutaneous adipose area in patients with overweight (all p < 0.05). (3) Iron levels and CAP values were decreased gradually 6 months and 1 year after surgery (all p < 0.05). CONCLUSIONS: Overall, our results indicated that iron is associated with hepatic steatosis in obesity. The iron level was significantly higher in patients with severe NAFLD than with mild or moderate NAFLD. LSG may reduce iron levels while improving fat deposition in the liver.
Authors: Mônica Rodrigues de Araújo Souza; Margareth de Fátima Formiga de Melo Diniz; José Eymard Moraes de Medeiros-Filho; Maria Salete Trigueiro de Araújo Journal: Arq Gastroenterol Date: 2012 Jan-Mar