Joana Perez-Tejada1, Ibane Aizpurua-Perez2, Ainitze Labaka3, Oscar Vegas4, Gurutze Ugartemendia5, Amaia Arregi6. 1. Oncologic Center (Onkologikoa), 121 Beguiristain, 20014 San Sebastian, Spain. Electronic address: jperez@onkologikoa.org. 2. Department of Basic Psychological Processes and their Development, University of The Basque Country, 70 Tolosa Av., 20018 San Sebastian, Spain. Electronic address: ibane.aizpurua@ehu.eus. 3. Department of Nursing II, University of The Basque Country, 105 Beguiristain, 20014, San Sebastian, Spain. Electronic address: ainitze.labaca@ehu.eus. 4. Department of Basic Psychological Processes and their Development, University of The Basque Country, 70 Tolosa Av., 20018 San Sebastian, Spain. Electronic address: o.vegas@ehu.eus. 5. Oncologic Center (Onkologikoa), 121 Beguiristain, 20014 San Sebastian, Spain. Electronic address: gugartemendia@onkologikoa.org. 6. Department of Basic Psychological Processes and their Development, University of The Basque Country, 70 Tolosa Av., 20018 San Sebastian, Spain. Electronic address: amaia.arregi@ehu.eus.
Abstract
OBJECTIVE: To examine the extent to which anxiety and depressive symptoms, self-esteem and proinflammatory cytokines interact to significantly predict quality of life in breast cancer survivors. METHODS: Cross-sectional data were collected from 134 breast cancer survivors. Hospital Anxiety and Depression Scale, Rosenberg Self-Esteem Scale and Quality of Life in Adult Cancer Survivors questionnaire, which includes the generic quality of life (QOL) and the quality of life related to cancer (QOLRC) subscales, were administered. Plasma IL-6 and TNF-α levels were measured using ELISA kits. Moderation analyses were performed to study the influence of psychobiological variables on quality of life. RESULTS: Anxiety and depressive symptoms, TNF-α predicted QOL scores, and both medium and high levels of TNF-α influenced the negative conditional effect of depressive symptoms on QOL. Anxiety symptoms and TNF-α was associated with QOLRC scores, and lower self-esteem predicted poorer QOLRC when women had high levels of TNF-α. CONCLUSIONS: These results highlight the booster effect of TNF-α for poorer quality of life in breast cancer survivors, both alone and in combination with depressive symptoms or low self-esteem. The study provides a framework for assessing subclinical markers, identifying vulnerable survivors and implementing psychological strategies to improve quality of life.
OBJECTIVE: To examine the extent to which anxiety and depressive symptoms, self-esteem and proinflammatory cytokines interact to significantly predict quality of life in breast cancer survivors. METHODS: Cross-sectional data were collected from 134 breast cancer survivors. Hospital Anxiety and Depression Scale, Rosenberg Self-Esteem Scale and Quality of Life in Adult Cancer Survivors questionnaire, which includes the generic quality of life (QOL) and the quality of life related to cancer (QOLRC) subscales, were administered. Plasma IL-6 and TNF-α levels were measured using ELISA kits. Moderation analyses were performed to study the influence of psychobiological variables on quality of life. RESULTS:Anxiety and depressive symptoms, TNF-α predicted QOL scores, and both medium and high levels of TNF-α influenced the negative conditional effect of depressive symptoms on QOL. Anxiety symptoms and TNF-α was associated with QOLRC scores, and lower self-esteem predicted poorer QOLRC when women had high levels of TNF-α. CONCLUSIONS: These results highlight the booster effect of TNF-α for poorer quality of life in breast cancer survivors, both alone and in combination with depressive symptoms or low self-esteem. The study provides a framework for assessing subclinical markers, identifying vulnerable survivors and implementing psychological strategies to improve quality of life.
Authors: Daniel C McFarland; Meredith Doherty; Thomas M Atkinson; Robin O'Hanlon; William Breitbart; Christian J Nelson; Andrew H Miller Journal: Cancer Date: 2022-04-13 Impact factor: 6.921
Authors: Sameer Badri Al-Mhanna; Wan Syaheedah Wan Ghazali; Mahaneem Mohamed; Ali A Rabaan; Eman Y Santali; Jeehan H Alestad; Enas Y Santali; Sohaib Arshad; Naveed Ahmed; Hafeez Abiola Afolabi Journal: PeerJ Date: 2022-08-02 Impact factor: 3.061