Literature DB >> 3335213

Autocrine control of prolactin secretion by vasoactive intestinal peptide.

G Nagy1, J J Mulchahey, J D Neill.   

Abstract

The functions of vasoactive intestinal polypeptide (VIP) and the many other neuropeptides that are localized in the anterior pituitary gland remain unknown although VIP of hypothalamic origin is established to act as a PRL-releasing factor. Evidence is presented here that locally-produced VIP acts in an autocrine fashion to stimulate PRL release. VIP antibodies or a VIP antagonist profoundly but reversibly suppressed PRL secretion in primary cultures of rat pituitary cells or the GH3 cell line. This evidence was obtained with the use of a reverse hemolytic plaque assay for microscopic demonstration of PRL release from individual cells under conditions precluding cell-cell interaction. We suggest that most of the high rate of "spontaneous" PRL secretion attributed to lactotropes deprived of hypothalamic influence is due in fact to the stimulatory effects of VIP acting in an autocrine fashion.

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Year:  1988        PMID： 3335213     DOI： 10.1210/endo-122-1-364

Source DB:  PubMed          Journal:  Endocrinology        ISSN： 0013-7227            Impact factor:   4.736


  17 in total

1.  Autocrine regulation of prolactin secretion by endothelins throughout the estrous cycle.

Authors:  Béla Kanyicska; Michael T Sellix; Marc E Freeman
Journal:  Endocrine       Date:  2003 Feb-Mar       Impact factor: 3.633

2.  Vasoactive intestinal peptide (VIP) mediates the effect of estrogens on the dopaminergic tone in the hypothalamic-pituitary axis of ovariectomized (OVX) rats.

Authors:  M Lasaga; A Seilicovich; D Pisera; M C Díaz; M F Befumo; B H Duvilanski
Journal:  Endocrine       Date:  1997-02       Impact factor: 3.633

3.  Different ultrastructural localization of VIP and prolactin in anterior pituitary cells of rats chronically treated with estrogen.

Authors:  K Köves; I L Chen; T J Görcs; J G Scammell; A Arimura
Journal:  Endocrine       Date:  1996-10       Impact factor: 3.633

Review 4.  Paracrinicity: the story of 30 years of cellular pituitary crosstalk.

Authors:  C Denef
Journal:  J Neuroendocrinol       Date:  2008-01       Impact factor: 3.627

Review 5.  Ontogenic studies of the neural control of adenohypophyseal hormones in the rat. II. Prolactin.

Authors:  D Becú-Villalobos; I M Lacau-Mengido; G S Díaz-Torga; C Libertun
Journal:  Cell Mol Neurobiol       Date:  1992-02       Impact factor: 5.046

Review 6.  Towards a functional significance of peptides and biogenic amines produced by the anterior pituitary.

Authors:  H Houben; D Tilemans; C Denef
Journal:  J Endocrinol Invest       Date:  1990-11       Impact factor: 4.256

7.  Vasoactive intestinal peptide in the human pituitary gland and adenomas. An immunocytochemical study.

Authors:  D W Hsu; P N Riskind; E T Hedley-Whyte
Journal:  Am J Pathol       Date:  1989-08       Impact factor: 4.307

8.  Prolactin secretion in idiopathic hypogonadotropic hypogonadism during pulsatile luteinizing hormone-releasing hormone long-term administration.

Authors:  M Giusti; L Traverso; P Cavagnaro; R Torre; R Durante; G Giordano
Journal:  J Endocrinol Invest       Date:  1989-09       Impact factor: 4.256

9.  Medium flow rate modulates autocrine-paracrine feedback of GH and PRL release by perifused GH3 cells.

Authors:  M E Stachura; C A Lapp; J M Tyler; Y S Lee
Journal:  In Vitro Cell Dev Biol       Date:  1990-05

10.  Autocrine-paracrine inhibition of growth hormone and prolactin production by GH3 cell-conditioned medium.

Authors:  C A Lapp; J M Tyler; Y S Lee; M E Stachura
Journal:  In Vitro Cell Dev Biol       Date:  1989-06
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