Yue Xin1, Xiao Man Wang1, Yu Wang1, Yan Xiu Hu1, Li Qun Jia1. 1. Department of Ultrasound, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, 100045, China.
Abstract
OBJECTIVES: This study aimed to investigate the diagnostic value of ultrasound in children with perforation of congenital choledochal cysts. METHODS: Eligible patients recruited from January 2004 to December 2018 in our hospital were enrolled in this retrospective study. A total of 59 cases of congenital choledochal cysts with perforation were defined as the perforation group, and 100 cases of congenital choledochal cysts without perforation with similar symptoms were defined as the control group. Clinical features were analyzed and compared between the groups. The differential efficacy of varied diagnostic criteria was evaluated by a receiver operating characteristic analysis. RESULTS: Significant differences were found between the groups with respect to clinical characteristics (abdominal pain, vomiting, fever, and abdominal distention; all P < .01) and the disease onset age (P < .001), but the diagnostic efficacy of both was poor (both areas under the curve, <0.7). The interruption of bile duct continuity only occurred in the perforation group with high specificity of 100% but poor sensitivity of 18.6%. The discrimination of combined features was significantly better (area under the curve, 0.936) than that of the disease onset age and clinical characteristics, with observed sensitivity and specificity of 93.2% and 94.0%, respectively. CONCLUSIONS: Using specific features, ultrasound can effectively diagnose perforation of a congenital choledochal cyst in children.
OBJECTIVES: This study aimed to investigate the diagnostic value of ultrasound in children with perforation of congenital choledochal cysts. METHODS: Eligible patients recruited from January 2004 to December 2018 in our hospital were enrolled in this retrospective study. A total of 59 cases of congenital choledochal cysts with perforation were defined as the perforation group, and 100 cases of congenital choledochal cysts without perforation with similar symptoms were defined as the control group. Clinical features were analyzed and compared between the groups. The differential efficacy of varied diagnostic criteria was evaluated by a receiver operating characteristic analysis. RESULTS: Significant differences were found between the groups with respect to clinical characteristics (abdominal pain, vomiting, fever, and abdominal distention; all P < .01) and the disease onset age (P < .001), but the diagnostic efficacy of both was poor (both areas under the curve, <0.7). The interruption of bile duct continuity only occurred in the perforation group with high specificity of 100% but poor sensitivity of 18.6%. The discrimination of combined features was significantly better (area under the curve, 0.936) than that of the disease onset age and clinical characteristics, with observed sensitivity and specificity of 93.2% and 94.0%, respectively. CONCLUSIONS: Using specific features, ultrasound can effectively diagnose perforation of a congenital choledochal cyst in children.